Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Hepatoprotective Effect of Bark of Phellodendron amurense RUPR. on Liver Damage Induced by Carbon Tetrachloride

사염화탄소에 의한 간손상에 대한 황백의 간보호 효과 연구

  • Kwak, Chang-Geun (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jae-Eun (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Han-Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Shin, Sang-Woo (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Joo, Myoung-Su (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Ha, Ki-Tae (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
  • 곽창근 (동국대학교 한의과대학 병리학교실) ;
  • 김재은 (동국대학교 한의과대학 병리학교실) ;
  • 최달영 (동국대학교 한의과대학 병리학교실) ;
  • 정한솔 (부산대학교 한의학전문대학원 응용의학부) ;
  • 신상우 (부산대학교 한의학전문대학원 응용의학부) ;
  • 주명수 (부산대학교 한의학전문대학원 응용의학부) ;
  • 하기태 (부산대학교 한의학전문대학원 응용의학부)
  • Received : 2011.06.15
  • Accepted : 2011.08.11
  • Published : 2011.08.25
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Abstract

We evaluated the hepatoprotective activity of crude hot-water extracts of the traditional Korean medicinal herb, Phellodendri Cortex (PC; Bark of Phellodendron amurense RUPR.), in an experimental model of hepatic damage induced by carbon tetrachloride ($CCl_4$). The serum marker of liver damage, sGOT, sGPT and sALP, were significantly decreased in the liver of the PC treated rats, compared with that of $CCl_4$ treated group. The histological observation of liver section of rats, showed the same protective effect of PC treatment. And the protective activity of PC was more significant in the post-treated group than pre-treated group. The significant decrease of malodialdehyde and increase of glutathion, catalase activity were observed in the liver homogenate of PC treated rats. Based on these findings, it is suggested that PC has potent hepatoprotective effects and the mechanism of the protection may be related to antioxidation pathways.

Keywords

References

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