DOI QR코드

DOI QR Code

Biological Activities of Water and Ethanolic Extracts from Allium victorialis L. Mature Leaves

  • Li, Chunmei (College of Biomedical Science, Kangwon National University) ;
  • Lee, Young-Mee (Division of Forest Resources, College of Forest and Environmental Sciences, Kangwon National University) ;
  • Lee, Kyeong-Cheol (Department of Nursing, Kangwon National University) ;
  • Han, Woong (College of Biomedical Science, Kangwon National University) ;
  • Wang, Myeong-Hyeon (College of Biomedical Science, Kangwon National University) ;
  • Han, Sang-Sup (Department of Nursing, Kangwon National University)
  • Received : 2011.02.23
  • Accepted : 2011.07.20
  • Published : 2011.09.30

Abstract

Allium victorialis L. (A. victorialis) is a very popular vegetable in Korea. The most commonly used parts of this vegetable are the bulbs and young leaves. To determine if the mature leaves have any beneficial properties, we investigated antioxidant, anti-${\alpha}$-glucosidase, anti-inflammatory, and anticancer activities of water and ethanol extracts from A. victorialis. Antioxidant activity was evaluated by measuring total phenolic content, DPPH and superoxide radicals scavenging activities. The water extract from A. victorialis ($W{\cdot}A$. victorialis) exhibited higher antioxidant ability than the ethanol extract ($E{\cdot}A$. victorialis). Moreover, the water extract showed strong inhibitory effect on ${\alpha}$-glucosidase. On the other hand, the ethanol extract had greater anti-inflammatory activity on murine macrophage cells (RAW 264.7) and greater anticancer activities against human colon cancer cells (HT-29). These results suggest that mature leaves from E·A. victorialis may have health-enhancing effects.

Keywords

References

  1. McCue P, Kwon YI, Shetty MK. 2005. Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean. Asia Pac J Clin Nutr 14: 145-152.
  2. Abreu P, Matthew S, Gonzalez T, Costa D, Segundo MA, Fernandes E. 2006. Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. Life Sci 78: 1578-1585. https://doi.org/10.1016/j.lfs.2005.07.037
  3. Chen CY, Chen CH, Lo YC, Wu BN, Wang HM, Lo WL, Yen CM, Lin RJ. 2008. Anticancer activity of isoobtusilactone A from Cinnamomum kotoense: Involvement of apoptosis, cell-cycle dysregulation, mitochondria regulation, and reactive oxygen species. J Nat Prod 71: 933-940. https://doi.org/10.1021/np070620e
  4. Shale TL, Stirk WA, Staden J. 1999. Screening of medicinal plants used in Lesotho for anti-bacterial and anti-inflammatory activity. J Ethnopharmacol 67: 347-354. https://doi.org/10.1016/S0378-8741(99)00035-5
  5. Frizen NV. 1988. Onions plants of Siberia. Nauka, Novosibirsk, Russia. p 90.
  6. Malyshev LI, Peshkova GA. 1987. Flora of Siberia: Araceae-Orchidaceae. Nauka, Novosibirsk, Russia. Vol 4, p 61.
  7. Kim TG, Kim SH, Kang SY, Jung KK, Choi DH. 2000. Antiatherogenic effect of the extract of Allium victorialis on the experimental atherosclerosis in the rabbit and transgenic mouse. Kor J Pharmacogn 31: 149-156.
  8. Ham SS, Cui CB, Choi HT, Lee DS. 2004. Antimutagenic and cytotoxic effects of Allium victorialis extracts. Korean J Food Preserv 11: 221-226.
  9. Choi J, Lee KT, Kim WB, Park KK, Chung WY, Lee JH, Lim SC, Jung HJ, Park HJ. 2005. Effect of Allium victorialis var. platyphyllum leaves on triton WR-1339-induced and poloxamer-407-induced hyperlipidemic rats and on diet- induced obesity rats. Kor J Pharmacogn 36: 109-115.
  10. Kwon JE, Baek UH, Jung IC, Sohn HY. 2010. Biological activities of fresh juice of wild-garlic, Allium victorialis L. Korean J Food Preserv 17: 541-546.
  11. Andersen YM, Fossen T. 1995. Anthocyanins with an unusual acylation pattern from stem of Allium victorialis. Phytochemistry 40: 1809-1812. https://doi.org/10.1016/0031-9422(95)90025-Q
  12. Lim SC, Park HJ, Yun SY, Lee MS. 1996. Structures of flavonoids and furostanol glycosides isolated from bulbs of Allium victorialis L. J Kor Soc Hort Sci 37: 675-679.
  13. Jung MJ, Heo SI, Wang MH. 2008. Free radical scavenging and total phenolic contents from methanolic extracts of Ulmus davidiana. Food Chem 108: 482-487. https://doi.org/10.1016/j.foodchem.2007.10.081
  14. Zhang ZJ, Liao LP, Moore J. 2009. Antioxidant phenolic compounds from walnut kernels (Juglans regia L.). Food Chem 113: 160-165. https://doi.org/10.1016/j.foodchem.2008.07.061
  15. Ewing JP, Janero DR. 1995. Microplate superoxide dismutase assay employing a nonenzymatic superoxide generator. Anal Biochem 232: 243-248. https://doi.org/10.1006/abio.1995.0014
  16. Nishioka T, Wabata J, Aoyama Y. 1998. Baicalein, α-glucosidase inhibitor from Scutellaria baicalensis. J Nat Prod 61: 1413-1415. https://doi.org/10.1021/np980163p
  17. Choi DB, Park SS, Ding JL, Cha WS. 2007. Effects of Fomitopsis pinicola extracts on antioxidant and antitumor activities. Biotechonol Bioprocess Eng 12: 516-524. https://doi.org/10.1007/BF02931349
  18. Bailey GS, Williams DE. 1993. Potential mechanisms for food related carcinogens and anticarcinogens. Food Technol 47: 105-118.
  19. Steinberg D. 1993. Modified forms of low-density lipoprotein and atherosclerosis. J Internal Med 233: 227-232. https://doi.org/10.1111/j.1365-2796.1993.tb00980.x
  20. Dufour D, Pichette A, Mshvildadze V, Bradette-Hebert ME, Lavoie S, Longtin A, Laprise C, Legault J. 2007. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius. J Ethnopharmacol 111: 22-28. https://doi.org/10.1016/j.jep.2006.10.021
  21. Onyeneho SN, Hettiarachchy NS. 1992. Antioxidant activity of durum wheat bran. J Agric Food Chem 49: 1496- 1500.
  22. Andlauer W, Fürst P. 1998. Antioxidative power of phytochemicals with special reference to cereals. Cereal Foods World 43: 356-359.
  23. Oliveira AC, Valentim IB, Silva CA, Bechara EJH, Barros MP, Mano CM, Goulart MO. 2009. Total phenolic content and free radical scavenging activities of methanolic extract powders of tropical fruit residues. Food Chem 115: 469- 475. https://doi.org/10.1016/j.foodchem.2008.12.045
  24. Jayakumar T, Thomas PA, Geraldine P. 2009. In-vitro antioxidant activities of an ethanolic extract of the oyster mushroom, Pleurotus ostreatus. IFSET 10: 228-234.
  25. Horton ES. 1995. NIDDM-the devastating disease. Diabetes Res Clin Pract 28: 3-11. https://doi.org/10.1016/0168-8227(95)01087-T
  26. Patricia MH, Steven RH, Jennifer AW, Bryan WW. 2005. Effects of a medical food containing an herbal alpha-glucosidase inhibitor on postprandial glycemia and insulinemia in healthy adults. J Am Diet Assoc 105: 65-71.
  27. Alain DB. 1998. Hyperglycaemia and $\alpha$-glucosidase inhibitors. Diabetes Res Clin Pract 40: 51-55. https://doi.org/10.1016/S0168-8227(98)00043-6
  28. Floris AV, Peter LL, Reinier PA, Eloy HV, Guy ER, Chris VW. 2005. $\alpha$-Glucosidase inhibitors for patients with type 2 diabetes. Diabetes Care 28: 154-162. https://doi.org/10.2337/diacare.28.1.154
  29. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. 2007. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol 147: 227-235.
  30. Osadebe PO, Okoye FBC. 2003. Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves. J Ethnopharmacol 89: 19-24. https://doi.org/10.1016/S0378-8741(03)00195-8
  31. Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E, Doseff AI. 2007. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol 179: 7121-7127. https://doi.org/10.4049/jimmunol.179.10.7121
  32. Hortelano S, Zeini M, Bosca L. 2002. Nitric oxide and resolution of inflammation. Methods Enzymol 359: 459- 465. https://doi.org/10.1016/S0076-6879(02)59208-9
  33. Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. 2008. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25: 2097-2116. https://doi.org/10.1007/s11095-008-9661-9
  34. Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M. 2005. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 366: 1784-1793. https://doi.org/10.1016/S0140-6736(05)67725-2