Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Chemotype Discrimination and Rapid Identification of Angelica Roots by DART-TOF-MS

  • Kim, Hye-Jin (Division of Pharmacognosy, College of Pharmacy, Kyung Hee University) ;
  • Piao, Xiang-Lan (Institute of Chinese Minority Traditional Medicine, Minzu University of China) ;
  • Jang, Young-Pyo (Division of Pharmacognosy, College of Pharmacy, Kyung Hee University)
  • Received : 2011.06.17
  • Accepted : 2011.08.24
  • Published : 2011.09.30
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Abstract

The Angelica root has been used as a medicinal herb in many Asian countries including Korea, China, and Japan. Angelica gigas, A. sinensis, and A. acutiloba have been considered as Angelicae radix in Korean, Chinese, and Japanese Pharmacopoeia, respectively. Since the origins of Angelicae radix differ from country to country, there is a need to develop an efficient analytical method to identify the origin of the Angelica root. In order to obtain chemical fingerprints, three different Angelicae Radices were analyzed by direct analysis in real time mass spectrometry (DART-MS). Significantly different DART-MS spectra were observed from three different species of Angelicae Radix. Strong peaks of decursin or decusinol angelate, and its dimer were exclusively found from A. gigas. Ligustilide and linoleic acid were detected as the major component from A. acutiloba. The strongest ligustilide peak was observed from A. sinensis. DART-MS fingerprinting is a promising method for the rapid identification and/or quality control of Angelicae Radix.

Keywords

References

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