약학회지 (YAKHAK HOEJI)

  • 제55권4호
  • /
  • Pages.319-323
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  • 2011
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

HT22 세포에서 Curcumin 유도체가 Heme Oxygenase-1 발현에 미치는 효과

Effect of Curcumin Derivatives on Heme Oxygenase-1 Expression in HT22 Cells

  • 정용관 (원광대학교병원 마취통증학과) ;
  • 이윤정 (원광대학교 의약자원연구소) ;
  • 천현자 (원광대학교 의약자원연구소) ;
  • 류일환 (원광대학교 의약자원연구소) ;
  • 지연주 (원광대학교 의약자원연구소) ;
  • 채권우 (원광대학교 의약자원연구소) ;
  • 김영숙 (원광대학교 의약자원연구소) ;
  • 손지우 (원광대학교 의약자원연구소) ;
  • 강현규 (원광대학교 의약자원연구소) ;
  • 이성희 (원광대학교 의약자원연구소) ;
  • 안인파 (원광대학교 의약자원연구소) ;
  • 정헌택 (원광대학교 의약자원연구소) ;
  • 배현옥 (원광대학교 의약자원연구소)
  • Cheong, Yong-Kwan (Department of Anesthesiology and Pain Medicine, School of Medicine) ;
  • Lee, Yun-Jung (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Chun, Hyun-Ja (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Ryu, Il-Hwan (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Jee, Yeon-Ju (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Chae, Gwon-U (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Kim, Young-Sook (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Shon, Ji-Ue (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Kang, Hyun-Gyu (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Lee, Sung-Hee (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • An, Ren-Bo (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Chung, Hun-Taeg (Medical Resources Research Institute (MeRRI), Wonkwang University) ;
  • Pae, Hyun-Ock (Medical Resources Research Institute (MeRRI), Wonkwang University)
  • 투고 : 2011.08.08
  • 심사 : 2011.08.11
  • 발행 : 2011.08.31
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초록

Curcumin, of which a critical characteristic is the capacity of crossing the blood-brain barrier, has been reported to induce the expression of neuroprotective heme oxygenase (HO)-1. The aim of this study is to compare HO-1-inducing capacity and neuroprotective activity of curcumin, its demethoxy (demethoxycurcumin, DMC; bis-demethoxycurcumin, BDMC) and hydrogenated derivatives (tetrahydrocurcumin, THC) in mouse hippocampal HT22 cells. Curcumin attenuated glutamate-induced cell death through HO-1 expression. DMC lacking a methoxy group on one of the aromatic rings possessed slightly lower activity in HO-1 expression and neuroprotection than curcumin. Similarly, BDMC, which lacks two methoxy groups on both of the aromatic rings, showed less activity than curcumin. These findings suggest that the presence of methoxy groups on the aromatic ring is required to enhance neuroprotective HO-1 expression. The reduction of the diarylheptadienone chain of curcumin by hydrogen, as in THC, was accompanied by a complete loss of ability to induce HO-1 expression and neuroprotection, suggesting that the conjugated double bonds of the central seven-carbon chain of curcumin may be essential for its ability to induce neuroprotective HO-1 expression. Our findings may provide useful information for further development of neuroprotective HO-1 inducers.

키워드

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