Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Acorus Gramineus on the Relaxation of Corpus Cavernosum Smooth Muscle

석창포에 의한 발기부전 개선 효과

  • Li, Xiang (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Ho-Tae (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jae-Yun (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jung (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Shin, Hong-Kyun (Rehabilitation Medicine, Joonghwa Medical Center) ;
  • Kang, Dae-Gill (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 리향 (원광대학교 한의과대학 & 한의학전문대학원) ;
  • 김호태 (원광대학교 한의과대학 & 한의학전문대학원) ;
  • 이재윤 (원광대학교 한의과대학 & 한의학전문대학원) ;
  • 이윤정 (원광대학교 한의과대학 & 한의학전문대학원) ;
  • 신홍균 (안양중화한방병원, 재활의학과) ;
  • 강대길 (원광대학교 한의과대학 & 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의과대학 & 한의학전문대학원)
  • Received : 2011.08.12
  • Accepted : 2011.10.13
  • Published : 2011.10.25
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Abstract

The aim of the present study is to investigate whether an ethanol extract of Acorus gramineus Soland (EAG) augments penile erection in vitro and in vivo experiment. Preconstructed with phenylephrine (PE) in isolated endothelium-intact rabbit corpus cavernosum, EAG relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-argininemethylester (L-NAME), a nitricoxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-${\alpha}$]-quinoxalin-1-one (ODQ), a soluble guanylylcyclase (sGC) inhibitor, respectively. EAG-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium (TEA), a nonselective $K^+$ channel blocker. EAG increased cGMP levels of the rabbit corpus cavernosum in a concentration-dependent manner without changes in cAMP levels. In addition, EAG caused increase of peak intracavernous pressure (ICP), ICP/MAP ratio and area under the carve (AUC) in SD rats. Taken together, these results suggest that EAG augments penile erection via NO-cGMP system and $K^+$ channels in corpus cavernosum.

Keywords

References

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