한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제28권2호
  • /
  • Pages.196-202
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  • 2011
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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항염증 활성을 갖는 탱자 추출물 합성

Synthesis of Trifoliate Orange Extract Having Anti inflammation Activities

  • 김덕술 (동명대학교 의용공학과) ;
  • 노언주 (창원대학교 화공시스템공학과)
  • Kim, Duck-Sool (Department of biomedical Engineering, Tongmyong University) ;
  • Roh, Eon-Joo (Department of Chemical Engineering, Changwon National University)
  • Received : 2011.04.22
  • Accepted : 2011.06.20
  • Published : 2011.06.30
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Abstract

Coumarin derivatives were shown to possess valuable pharmacological properties such as anticancer/anti carcinogenic, anti-inflammatory, anti helicobacter, anti genotoxic, neuroprotective and dietary effect. In this study, novel coumarin derivatives structurally related to 7-geranyloxycoumarin were effectively synthesised in good yields by $Cs_2CO_3$/acetonitrile in mild condition. The synthesis of geranyloxycoumarin derivatives in weak base($Na_2CO_3$, $K_2CO_3$, $Cs_2CO_3$ etc)/$CH_3CN$ at room temperature obtained in good yield. On the other hand, the reaction of geranyloxycoumarin formation in strong base(NaOH, KOH, CsOH etc)/$CH_3CN$ at reflux condition obtained in low yield.

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References

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