Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Soy Protein Consumption and Bone Mineral Density in Early Postmenopausal Korean Women

한국인 폐경기 여성에서 콩 단백질 섭취량과 골밀도의 연관성

  • Kim, Young-Ran (Department of preventive Medicine and Public Health, Chungnam National University School of Medicine and Research Institute for Medical Sciences) ;
  • Nam, Hae-Sung (Department of preventive Medicine and Public Health, Chungnam National University School of Medicine and Research Institute for Medical Sciences) ;
  • Lee, Tae-Yong (Department of preventive Medicine and Public Health, Chungnam National University School of Medicine and Research Institute for Medical Sciences)
  • 김영란 (충남대학교 의학전문대학원 예방의학교실) ;
  • 남해성 (충남대학교 의학전문대학원 예방의학교실) ;
  • 이태용 (충남대학교 의학전문대학원 예방의학교실)
  • Received : 2012.07.24
  • Accepted : 2012.10.11
  • Published : 2012.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

This study was conducted to investigate the association between soy protein intake and bone mineral density (BMD) in women using data from 2008 and 2009 Korea National Health and Nutrition Examination Survey (KNHANES). The study sample comprised 686 Korean women who were within the first 12 years of postmenopause and had no history of hysterectomy. Adjusting for age, weight, height and calcium intake, statistical analysis was performed among women under 4 years postmenopausal and at least 4 years postmenopausal, respectively. Among women under 4 years postmenopausal, there was no significant association between soy protein intake and BMD at lumbar spine or proximal femur. On the other hand, in the later postmenopausal women, there was a reverse correlation between soy protein intake and BMD, especially at the femoral neck and the total hip. However, the correlation disappeared with additional adjustment for total protein intake, Na intake and energy intake. In conclusion, there may be no correlation between soy protein intake and bone density in Korean menopausal women.

본 연구는 2008-2009년 국민건강영양조사 자료에서 자궁절제술을 하지 않은 폐경 후 12년 미만의 폐경기 여성 686명을 대상으로 콩 단백질 섭취량과 요추 및 대퇴골 골밀도의 연관성을 알아보고자 하였다. 연구대상을 골 소실이 상대적으로 빠른 폐경 후 4년 미만 기간에 있는 여성군과 폐경후 4년 이상인 여성군으로 층화하여 각각 콩 단백질 섭취량과 골밀도의 관계를 분석하였다. 연령, 체중, 신장, 칼슘 섭취량 등을 보정하였을 때 폐경 후 4년 미만인 여성군에서는 콩 단백질 섭취량과 요추 및 대퇴골 골밀도 사이에 유의한 연관성이 없었다. 반면 동일한 보정을 하였을 때 폐경 후 4년 이상인 여성에서는 콩 단백질 섭취와 대퇴골(femoral neck, total hip 부위) 골밀도 사이에는 역방향의 유의한 연관성이 있었으나, 총단백질 섭취량, Na섭취량, 에너지섭취량을 추가 보정한 결과 그 연관성이 사라졌다. 결론적으로 한국인 폐경기 여성에서 콩 단백질 섭취와 골밀도는 연관성이 없는 것으로 사료된다.

Keywords

References

  1. Messina M, Messina V., Soy foods, soybean isoflavones and health a brief overview., J Ren Nutr, 10(2), pp63-68, 2000. https://doi.org/10.1016/S1051-2276(00)90001-3
  2. Potter SM, Baum JA, Teng H, Stillman RJ, Erdman JW Jr, Soy protein and isoflavones: their effects on blood lipidsand bone density in postmenopausal women, Am J Clin Nutr, 68, pp1375S-.1379S, 1998.
  3. De-Fu Ma., Li-Qiang Qin., Pei-Yu Wang., Ryohei Katoh, Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Metaanalysis of randomized controlled trials, Clinical Nutrition, 27, pp57-64, 2008 https://doi.org/10.1016/j.clnu.2007.10.012
  4. Gallagher JC, Rafferty K, Haynatzka V, Wilson M ., Effect of soy protein on bone metabolism. Presented at Third international symposium on the role of soy in preventing and teaching chronic disease, Oct 31 -.Nov 3, Washington D.C. 1999.
  5. Ho SC, Chan SG, Yi Q, Wong E, Leung PC, Soy intake and the maintenance of peak bone mass in Hong Kong Chinese Women. J Bone Miner Res, 16, pp1363-1369, 2001. https://doi.org/10.1359/jbmr.2001.16.7.1363
  6. JIE MEI, SHIRLEY S. C., Yeung and ANNIE W. C., Kung, High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women, J Clin Endocrinol Metab, 86(11), pp5217-5221, 2001. https://doi.org/10.1210/jc.86.11.5217
  7. Recker R, Lappe J, Davies K, Heaney R, Characterization of perimenopausal bone loss: a prospective study, J Bone Miner Res, 15, pp1965-1973, 2000. https://doi.org/10.1359/jbmr.2000.15.10.1965
  8. Suzanne C. Ho, Jean Woo, Silvia Lam, Yuming Chen, Aprille Sham, Joseph Lau., Soy protein consumption and bone mass in early postmenopausal Chinese woman, Osteoporosis Int, 14, pp835-842, 2003. https://doi.org/10.1007/s00198-003-1453-9
  9. Kyoko Taku PhD, Melissa K Melby PhD, Jun Takebayashi PhD, Shoichi Mizuno PhD, Yoshiko Ishimi PhD, Toyonori Omori PhD, Shaw Watanabe PhD., Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials, Asia Pac J Clin Nutr, 19(1), pp33-42, 2010.
  10. K.E. Wangen.,, A. M. Duncan., B. E. Merz- Demlow., et al., "Effects of soy soflavones on markers of bone turnover in premenopausal and postmenopausal women", Clinical Endocrinology and Metabolism, 85(9), pp3043-3048, 2000. https://doi.org/10.1210/jc.85.9.3043
  11. Gye Soon SON, Effect of Soybean Intake on Bone Mineral Density and Bone Turnover Markets in Postmenopausal Women, Kyungpook National University, 2005.