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Toxicity Evaluation of Irradiated Tarakjuk for Three Months

감마선 조사 타락죽의 3개월 반복투여 독성평가

  • Yin, Xing Fu (Dept. of Food Sciences and Nutrition & Life Science, Hallym University) ;
  • Jeon, Young Eun (Dept. of Food Sciences and Nutrition & Life Science, Hallym University) ;
  • Kim, Tae-Keun (Dept. of Food Sciences and Nutrition & Life Science, Hallym University) ;
  • Shim, Jae-Hoon (Dept. of Food Sciences and Nutrition & Life Science, Hallym University) ;
  • Kang, Il-Jun (Dept. of Food Sciences and Nutrition & Life Science, Hallym University)
  • 윤성복 (한림대학교 식품영양학과.생명과학과) ;
  • 전영은 (한림대학교 식품영양학과.생명과학과) ;
  • 김태근 (한림대학교 식품영양학과.생명과학과) ;
  • 심재훈 (한림대학교 식품영양학과.생명과학과) ;
  • 강일준 (한림대학교 식품영양학과.생명과학과)
  • Received : 2012.07.25
  • Accepted : 2012.08.09
  • Published : 2012.11.30

Abstract

This study was conducted to evaluate the possible subacute toxicity of gamma-irradiated Tarakjuk. Tarakjuk was irradiated at a dose of 30 kGy at room temperature. For the animal study, AIN-93G as a control diet and 30 kGy irradiated and non-irradiated Tarakjuk diets were administered to male and female ICR mice (10 mice per group) for 3 months. During the experimental period, the group fed 30 kGy irradiated Tarakjuk did not show any changes in appearance, behavior, mortality, body weight, organ weight, or food consumption compared to control. Further, all biochemical parameters were in normal ranges. In the histopathological examination of liver and kidney tissues of ICR mice, there were no significant differences between the control and 30 kGy irradiated Tarakjuk groups. These results indicate that Tarakjuk irradiated at 30 kGy did not cause any toxic effects under these experimental conditions.

본 연구는 타락죽의 안전성을 확보하기 위해서 30 kGy 감마선 조사된 타락죽을 ICR 마우스에 3개월간 섭취시킨 다음 독성평가를 수행하였다. 비조사 타락죽 및 30 kGy 조사 타락죽을 암수 마우스에 투여를 한 결과 시험기간 동안 시험물질에 의한 임상증상이나 폐사 동물을 나타나지 않았으며, 체중변화, 사료섭취량 및 주요 장기 무게도 대조군에 비해 차이를 보이지 않았다. 혈액학적 검사 및 혈청학적 검사 모두 정상범위 내의 수치를 나타내었으며, 병리조직학적 검사 역시 간 및 신장 모두 염증, 괴사 등의 유의할 만한 병적 변화 없는 정상적인 구조를 유지하고 있었다. 따라서 30 kGy로 감마선 조사된 타락죽을 암수 마우스에 3개월간 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 나타났다.

Keywords

References

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