Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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The effect of onion on hyperlipidemia: Meta-analysis

양파의 고지혈증 효과에 대한 메타분석

  • Choi, Kiheon (Department of Information and Statistics, Duksung Women's University)
  • 최기헌 (덕성여자대학교 정보통계학과)
  • Received : 2012.10.02
  • Accepted : 2012.11.05
  • Published : 2012.11.30
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Abstract

In this study, we studied the effect of onion on hyperlipidemia in terms of factors, such as body weight, liver weight, kidney weight, heart weight, blood glucose, total cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol. The hyperlipidemia supplement was significantly effective on the liver weight, kidney weight, blood glucose, total cholesterol, triglycerides, and LDL-cholesterol with the fixed effect model. However, the liver weight, blood glucose, total cholesterol, and triglycerides were significantly decreased with the random effect model on the heterogeneous factors selected by Galbraith plot. The existence of publication bias was checked by using a funnel plot.

본 연구는 고지혈증에 대해 양파추출물을 투여한 무작위 대조군 전-후 실험설계 연구 12편을 대상으로 체중, 간 무게, 신장 무게, 심장 무게, 혈당, 총콜레스테롤, 트리글리세리드, HDL-콜레스테롤, LDL-콜레스테롤의 평균비교를 통해 양파의 효능에 대해 알아보았다. 고정효과모형을 적용시킨 결과 체중과 심장 무게를 제외한 간 무게, 신장 무게, 혈당, 총콜레스테롤 농도, 트리글리세리드 농도, LDL-콜레스테롤 농도는 유의한 감소를 보였고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 갈브레스 그림으로 동질성 여부를 알아보았고 동질성을 만족하지 않은 변수에 대해 랜덤효과모형을 적용시킨 결과 간 무게와 혈당, 총 콜레스테롤 농도, 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈고, HDL-콜레스테롤 농도는 유의하게 증가하였다. 각 변수에 대해 출판편의의 존재를 알아보았고, 출판편의의 존재를 확인 후 절단과 보충 방법으로 대체값을 추정하였다.

Keywords

References

  1. An, S. J. and Kim, M. K. (2001). Effect of dry powders, ethanol extracts and juices of radish and onion on lipid metabolism and antioxidative capacity in rats. The Korean Journal of Nutrition Society, 34, 513-524.
  2. Bang, M. A., Kim, H. A. and Cho, Y. J. (2009). Alterations in the blood glucose, serum lipid and renal oxidative stress in diabetic rats by supplementation of onion (Allium cepa. Linn). Nutrition Research and Practice, 3, 242-246. https://doi.org/10.4162/nrp.2009.3.3.242
  3. Cho, Y. J., Park, H. J., Ju, S. M. and Hou, W. N. (2006). Effects of dietary dae-chu (rhamnaceae ziziphus), onion(allium cepa l.), mixture extract on serum composition in rats. The Korean Journal of Food Culture, 21, 99-106.
  4. Choi, K. H. and Kook, S. J. (2008). Meta analysis using MIX, Free Academy, Seoul.
  5. Kang, M., Joung, H., Lim, J., Lee, Y. and Song, Y. (2011). Secular trend in dietary patterns in korean adult population, using the 1998, 2001, and 2005 korean national health and nutrition examination survey. The Korean Journal of Nutrition Society, 44, 152-161. https://doi.org/10.4163/kjn.2011.44.2.152
  6. Kang, J. A. and Kang, J. S. (1997). Effect of garlic and onion on plasma and liver cholesterol and triacylglycerol and platelet aggregation in rats fed basal or cholesterol supplemented diets. The Korean Journal of Nutrition Society, 30, 132-138.
  7. Kim, J. Y., Seo, Y. J., Noh, S. K. and Cha, Y. J. (2010). A concentrated onion extract lowers serum lipid levels in rats fed a high-fat diet. The Korean Journal of Food Preservation, 17, 398-404.
  8. Kim, M. J. and Choi, K. H. (2010). The anti-diabetic effects of propolis using Hedges' standardized mean difference. Journal of the Korean Data & Information Science Society, 21, 447-459.
  9. Kim, N. J. and Choi, K. H. (2012). Lipid metabolic effects of caffeine using meta-analysis. Journal of the Korean Data & Information Science Society, 23, 649-656. https://doi.org/10.7465/jkdi.2012.23.4.649
  10. Kim, S. K. and Kim, M. K. (2004). Effect of dried powders or ethanol extracts of onion flesh and oeel on lipid metabolism, antioxidative and antithrombogenic capacities in 16-month-old-rats. The Korean Journal of Nutrition Society, 37, 623-632.
  11. Kim, S. O. and Lee, M. Y. (2001). Effects of ethyl acetate fraction of onion lipid metabolism in high cholesterol-fed rats. Journal of the Korean Society of Food Science and Nutrition, 30, 673-678.
  12. Ko, H. Y. and Choi, K. H. (2010). The Anti-diabetic effects of cordyceps by using meta analysis. Journal of the Korean Data Analysis Society, 12, 1861-1873.
  13. Kook, S. J., Kim, G. H. and Choi, K. H. (2009). The effects of panax ginseng on streptozocin-lnduced diabetic rats: meta analysis, The Korean Journal of Applied Statistics, 22, 107-114. https://doi.org/10.5351/KJAS.2009.22.1.107
  14. Nam, K. H., Baik, H. W., Choi, T. Y., Yoon, S. G., Park, S. W. and Joung, H. J. (2007). Effect of ethanol extract of onion the lipid profiles in patients with hypercholesterolemia. The Korean Journal of Nutrition Society, 40, 242-248.
  15. Park, J. H., Kim, J. M., Park, E. J. and Lee, K. H. (2008). Effects of chungkukjang added with onion on lipid and antioxidant metabolism in rats fed high fat-cholesterol diet. Journal of the Korean Society of Food Science and Nutrition, 37, 1244-1250. https://doi.org/10.3746/jkfn.2008.37.10.1244
  16. Sheo, H. J. and Jung, D. L. (1997). The Effects of onion juice on serum lipid levels in rats. Journal of the Korean Society of Food Science and Nutrition, 26, 1164-1172.
  17. Sutton, A. J., Abrams, K. R., Jones, D. R., Sheldon, T. A. and Song, F. (2000). Methods for meta-analysis in medical research. John Wily & Sons, Ltd.
  18. Woo, H. S., Aan, B. J., Bae, J. H., Kim, S., Choi, H. J., Han, H. S. and Choi, C. (2003). Effect of biologically active fractions from onion on physiological activity and lipid metabolism. Journal of the Korean Society of Food Science and Nutrition, 32, 119-123. https://doi.org/10.3746/jkfn.2003.32.1.119
  19. Yang, Y. R., Kim, H. L. and Park, Y. K. (2008). Effects of onion kimchi extract supplementation on blood glucose and serum lipid contents in streptozotocin-induced diabetic rats. Journal of the Korean Society of Food Science and Nutrition, 37, 445-451. https://doi.org/10.3746/jkfn.2008.37.4.445

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