Asian Pacific Journal of Cancer Prevention

  • 제13권8호
  • /
  • Pages.3751-3755
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Effect of Tea Polyphenols on the Adhesion of Highly Metastatic Human Lung Carcinoma Cell Lines to Endothelial Cells in Vitro

  • Zheng, Feng-Jin (Huaxi College of Preclinical Medicine and Forensic Medicine, Sichuan University) ;
  • Shi, Lin (College of Pharmacy and Academician Workstation for Natural Medicine Research of Henan Province) ;
  • Yang, Jun (College of Pharmacy and Academician Workstation for Natural Medicine Research of Henan Province) ;
  • Deng, Xiao-Hui (College of Basic Medicine, Xinxiang Medical University) ;
  • Wu, Yu-Quan (117 Hospital of People's Liberation Army) ;
  • Yan, Xi-Qing (College of Pharmacy and Academician Workstation for Natural Medicine Research of Henan Province) ;
  • Huang, Ning (Huaxi College of Preclinical Medicine and Forensic Medicine, Sichuan University)
  • 발행 : 2012.08.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Aim: Tea polyphenols are known to play roles in critical steps of human lung carcinoma cell metastasis. For understanding the mechanisms whereby they inhibit tumor metastasis, the present study was conducted to investigate their effects on the adhesion of highly metastatic lung carcinoma cell lines (PG cells) to endothelial cells (EC cells) and adhesion molecule expression in vitro. Methods: The expression of CD44 or CD54 in the PG cells was detected by flow cytometry and adhesion of PG cells to EC cells was assessed by confocal microscopy double fluorescence staining. Results: The results showed that tea polyphenols: (1) inhibited the expression of CD44 and CD54, two important adhesion molecules in the PG cells in a dose-dependent manner; (2) significantly blocked the adhesion of PG cells to EC cells not only in a state of rest but also when active; and (3) influenced CD44 and CD54 expression during the adhesion process of PG cells to EC cells. Conclusions: The data indicated that the blocking role of tea polyphenols in the adhesion of PG cells to EC cells is related to CD44 and CD54. The mechanism of tea polyphenol prevention of human lung carcinoma metastasis might be through inhibiting adhesion molecule expression to block cancer cell adhesion.

키워드

참고문헌

  1. Albelda SM (1993). Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest, 68, 4-17.
  2. Beiras-Fernandez A, Chappell D, Hammer C, et al (2009). Impact of polyclonal anti-thymocyte globulins on the expression of adhesion and inflammation molecules after ischemia-reperfusion injury. Transpl Immunol, 20, 224-8. https://doi.org/10.1016/j.trim.2008.11.004
  3. Bourrguignon LY, Iida N, Welsh CF, Zhu D, Krongrad A, Pasquale D (1995). Involvement of CD44 and its variant isoforms in membrane-cytoskeleton interaction, cell adhesion and tumor metastasis. J Neuro-Oncol, 26, 201-8. https://doi.org/10.1007/BF01052623
  4. Chung FL, Schwartz J, Herzog CR, Yang YM (2003). Tea and cancer prevention: Studies in animals and humans. J Nutr, 133, S3268-74. https://doi.org/10.1093/jn/133.10.3268S
  5. Crespy V, Williamson G (2004). A review of the health effects of green tea catechins in in vivo animal models. J Nutr, 134(12s), S3431-40. https://doi.org/10.1093/jn/134.12.3431S
  6. Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH (2008). Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an eastern cooperative oncology group study. Clin Cancer Res, 14, 1407-12. https://doi.org/10.1158/1078-0432.CCR-07-1154
  7. Dreosti IE, Wargovich MJ, Yang CS (1997). Inhibition of carcinogenesis by tea: the evidence from experimental studies. Crit Rev Food Sci, 37, 761-70. https://doi.org/10.1080/10408399709527801
  8. Dworakowski R, Alom-Ruiz SP, Shah AM (2008). NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype. Pharmacol Rep, 60, 21-8.
  9. Frijns CJ, Kappelle LJ, van Gijn J, et al (1997). Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis. Stroke, 28, 2214-8. https://doi.org/10.1161/01.STR.28.11.2214
  10. Fukazawa H, Yoshida K, Ichinohasama R, et al (1993). Expression of the Hermes-1 (CD44) and ICAM-1 (CD54) molecule on the surface of thyroid cells from patients with Graves' disease. Thyroid, 3, 285-9. https://doi.org/10.1089/thy.1993.3.285
  11. Gassmann P, Haier J (2008). The tumor cell-host organ interface in the early onset of metastatic organ colonization. Clin Exp Metastas, 25,171-81. https://doi.org/10.1007/s10585-007-9130-6
  12. Grothey A, Heistermann P, Philippou S, Voigtmann R (1998). Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage. Brit J Cancer, 77, 801-7. https://doi.org/10.1038/bjc.1998.130
  13. Guo Y, Wang S, Hoot DR, Clinton SK (2007). Suppression of VEGF-mediated autocrine and paracrine interactions between prostate cancer cells and vascular endothelial cells by soy isoflavones. J Nutr Biochem, 18, 408-17. https://doi.org/10.1016/j.jnutbio.2006.08.006
  14. Hamburger SA, McEver RP (1990). GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood, 75, 550-4.
  15. Higdon JV, Frei B (2003). Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci, 43, 89-143. https://doi.org/10.1080/10408690390826464
  16. Isemura M, Suzuki Y, Satoh K, Narumi K, Motomiya M (1993). Effects of catechins on the mouse lung carcinoma cell adhesion to the endothelial cells. Cell Biol Int, 17, 559-64. https://doi.org/10.1006/cbir.1993.1099
  17. Jayabalan R, Chen PN, Hsieh YS, et al (2011). Effect of solvent fractions of kombucha tea on viability and invasiveness of cancer cells-Characterization of dimethyl 2-(2-hydroxy- 2-methoxypropylidine) malonate and vitexin. Indian J Biotechnol, 10, 75-82
  18. Jiang CG, Li JB, Liu FR, et al (2007). Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression. Anticancer Res, 27(4B), 2439-47.
  19. Ju J, Lu G, Lambert JD, Yang CS (2007). Inhibition of carcinogenesis by tea constituents. Semin Cancer Biol, 17, 395-402. https://doi.org/10.1016/j.semcancer.2007.06.013
  20. Khaldoyanidi SK, Glinsky VV, Sikora L, et al (2003). MDAMB- 435 Human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions. J Biol Chem, 278, 4127-34. https://doi.org/10.1074/jbc.M209590200
  21. Khan N, Mukhtar H (2008). Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett, 269, 269-80. https://doi.org/10.1016/j.canlet.2008.04.014
  22. Khan N, Mukhtar H (2010). Cancer and metastasis: prevention and treatment by green tea. Cancer Metast Rev, 29, 435-445. https://doi.org/10.1007/s10555-010-9236-1
  23. Kim CH, Moon SK (2005). Epigallocatechin-3-gallate causes the p21/WAF1-mediated G(1)-phase arrest of cell cycle and inhibits matrix metalloproteinase-9 expression in TNFalpha- induced vascular smooth muscle cells. Arch Biochem Biophys, 435, 264-272. https://doi.org/10.1016/j.abb.2004.12.022
  24. Konstantopoulos K, Thomas SN (2009). Cancer cells in transit: The vascular interactions of tumor cells. Annu Rev Biomed Eng, 11, 177-202. https://doi.org/10.1146/annurev-bioeng-061008-124949
  25. Lambert JD, Hong J, Yang GY, Liao J, Yang CS (2005). Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr, 81, S284-91. https://doi.org/10.1093/ajcn/81.1.284S
  26. Lawson C, Wolf S (2009). ICAM-1 signaling in endothelial cells. Pharmacol Rep, 61, 22-32. https://doi.org/10.1016/S1734-1140(09)70004-0
  27. Liang YC, Chen YC, Lin YL, et al (1999). Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3, 3-digallate. Carcinogenesis, 20, 733-6. https://doi.org/10.1093/carcin/20.4.733
  28. Limb GA, Chignell AH, Green W, LeRoy F, Dumonde DC (1996). Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol, 80, 168-73. https://doi.org/10.1136/bjo.80.2.168
  29. Lin JK, Liang YC, Lin-Shiau SY (1999). Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade. Biochem Pharmacol, 58, 911-5. https://doi.org/10.1016/S0006-2952(99)00112-4
  30. Lisignoli G, Cristino S, Piacentini A, et al (2006). Hyaluronanbased polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol, 207, 346-73.
  31. Lowe JB, Stoolman LM, Nair RP, et al (1990). ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell, 63, 475-84. https://doi.org/10.1016/0092-8674(90)90444-J
  32. Maeda-Yamamoto M, Kawahara H, Tahara N, et al (1999). Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. J Agr Food Chem, 47, 2350-4. https://doi.org/10.1021/jf9811525
  33. Mukhtar H, Ahmad N (1999). Cancer chemoprevention: future holds in multiple agents. Toxicol Appl Pharm, 158, 207-10. https://doi.org/10.1006/taap.1999.8721
  34. Mukhtar H, Katiyar SK, Agarwal R (1994). Green tea and skin--anticarcinogenic effects. J Invest Dermatol, 102, 3-7. https://doi.org/10.1111/1523-1747.ep12371720
  35. Orr FW, Wang HH, Lafrenie RM, Scherbarth S, Nance DM (2000). Interactions between cancer cells and the endothelium in metastasis. J Pathol, 190, 310-29. https://doi.org/10.1002/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P
  36. Park JW, Jang YH, Kim JM, et al (2009). Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia. J Neurosci Res, 87, 567-75. https://doi.org/10.1002/jnr.21847
  37. Polley MJ, Phillips ML, Wayner E, et al (1991). CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. P Natl Acad Sci USA, 88, 6224-8. https://doi.org/10.1073/pnas.88.14.6224
  38. Rice GE, Gimbrone MA Jr, Bevilacqua MP (1988). Tumor cell-endothelial interactions. Increased adhesion of human melanoma cells to activated vascular endothelium. Am J Pathol, 133, 204-10.
  39. Rokhlin OW, Cohen MB (1996). Soluble forms of CD44 and CD54 (ICAM-1) cellular adhesion molecules are released by human prostatic cancer cell lines. Cancer Lett, 107, 29-35. https://doi.org/10.1016/0304-3835(96)04339-X
  40. Sandi MJ, Hamidi T, Malicet C, et al (2011). p8 Expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis. J Cell Physiol, 226, 3442-51. https://doi.org/10.1002/jcp.22702
  41. Tozawa K, Sakurada S, Kohri K, Okamoto T (1995). Effects of anti-nuclear factor ${\kappa}B$ reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res, 55, 4162-7.
  42. Wang Y, Lewis DF, Adair CD, et al (2009). Digibind attenuates cytokine TNF$\alpha$-induced endothelial inflammatory response: potential benefit role of Digibind in preeclampsia. J Perinatol, 29, 195-200. https://doi.org/10.1038/jp.2008.222
  43. Yang CS, Wang ZY (1993). Tea and cancer. J Natl Cancer I, 85, 1038-49. https://doi.org/10.1093/jnci/85.13.1038
  44. Yang CS, Maliakal P, Meng X (2002). Inhibition of carcinogenesis by tea. Annu Rev Pharmacol, 42, 25-54. https://doi.org/10.1146/annurev.pharmtox.42.082101.154309
  45. Yang CS, Wang X, Lu G, Picinich SC (2009). Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer, 9, 429-39. https://doi.org/10.1038/nrc2641
  46. Yang S, Zhang JJ, Huang XY (2009). Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell, 15, 124-34. https://doi.org/10.1016/j.ccr.2008.12.019

피인용 문헌

  1. Quantitative Proteomic Analysis Identifies CPNE3 as a Novel Metastasis-promoting Gene in NSCLC vol.12, pp.7, 2013, https://doi.org/10.1021/pr400273z
  2. The Interaction between LYVE-1 with Hyaluronan on the Cell Surface May Play a Role in the Diversity of Adhesion to Cancer Cells vol.8, pp.5, 2013, https://doi.org/10.1371/journal.pone.0063463
  3. Telmisartan Exerts Anti-Tumor Effects by Activating Peroxisome Proliferator-Activated Receptor-γ in Human Lung Adenocarcinoma A549 Cells vol.19, pp.3, 2014, https://doi.org/10.3390/molecules19032862
  4. Biophysical characteristics of proteins and living cells exposed to the green tea polyphenol epigallocatechin-3-gallate (EGCg): review of recent advances from molecular mechanisms to nanomedicine and clinical trials vol.46, pp.1, 2017, https://doi.org/10.1007/s00249-016-1141-2
  5. Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically vol.7, pp.1, 2017, https://doi.org/10.1038/srep42220