Asian Pacific Journal of Cancer Prevention

  • 제13권9호
  • /
  • Pages.4683-4688
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Transforming Growth Factor Beta-1 C-509T Polymorphism and Cancer Risk: A Meta-analysis of 55 Case-control Studies

  • Liu, Yang (Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College) ;
  • Lin, Xian-Fan (Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College) ;
  • Lin, Chun-Jing (Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College) ;
  • Jin, Si-Si (Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College) ;
  • Wu, Jin-Ming (Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College)
  • 발행 : 2012.09.30
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Aim: To investigate the association of transforming growth factor-beta 1 (TGF-${\beta}1$) C-509T polymorphism and susceptibility to cancer by means of meta-analysis. Methods: An extensive search was performed to identify eligible case-control studies investigating such a link. The strength of the association between TGF-${\beta}1$ C-509T polymorphism and cancer risk was assessed by pooled odds ratios (ORs) and 95%confidence intervals (95%CIs) in fixed or random effects models. Results: 55 published case-control studies with a total number of 21,639 cases and 28,460 controls were included. Overall, there was no association between TGF-${\beta}1$ C-509T and cancer risk in all genetic comparison models (TT vs. CC: OR=1.01, 95%CI=0.89-1.15; T vs. C: OR=1.01, 95%CI=0.94-1.07). However, a stratified analysis by cancer type indicated -509 T allele was significantly associated with decreased risk of colorectal cancer (CRC) (TT vs. CT/CC: OR=0.85, 95%CI=0.76-0.95), especially for Caucasians (TT vs. CT/CC: OR=0.83, 95%CI=0.71-0.98) and for population-based studies (TT vs. CT/CC: OR=0.78, 95%CI=0.68-0.89). Conclusion: This meta-analysis suggested that TGF-${\beta}1$ C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians.

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참고문헌

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