Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Phenethyl Isothiocyanate Inhibits Ovalbumin-induced Inducible Nitric Oxide Synthase Expression

Ovalbumin에 의해서 유도된 inducible nitric oxide synthase 발현에 대한 phenethyl isothiocyanate의 억제효과

  • Shin, Hwa-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
  • 신화정 (순천향대학교 의료과학대학 의료과학과) ;
  • 윤형선 (순천향대학교 의료과학대학 의료과학과)
  • Received : 2012.08.01
  • Accepted : 2012.09.14
  • Published : 2012.12.31
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Abstract

Egg allergies have been reported as one of the most prevalent food hypersensitivities in the pediatric population. One of the major egg allergens is ovalbumin (OVA), which is the major protein in the egg whites. Phenethyl isothiocyanate (PEIC) from cruciferous vegetables has an effect on anti-inflammatory therapy. In the present report, we show that PEIC inhibits the nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activation induced by OVA. PEIC also inhibits the OVA-induced inducible nitric oxide synthase (iNOS) expression and nitrite production. However, PEIC did not suppress the cyclooxygenase-2 (COX-2) expression induced by OVA. These results suggest that PEIC has the specific mechanism for anti-inflammatory responses and efficient anti-allergic activities.

이번 실험을 통하여 PEIC가 OVA에 의해 유도된 NF-${\kappa}B$ 활성과 iNOS, COX-2 발현에 어떠한 영향을 미치는지 알아 보았다. PEIC는 OVA에 의해 유도된 NF-${\kappa}B$ 활성을 억제시켰다. 또한 PEIC는 OVA에 의해 유도된 iNOS의 발현도 억제시켰다. 하지만 PEIC는 OVA에 의해 유도된 COX-2 발현은 억제시키지 못하였다. 이러한 결과는 iNOS와 COX-2가 서로 다른 메커니즘에 의해 조절된다는 것을 암시한다. 또한 PEIC는 알러지와 같은 만성적인 질병들을 조절할 수 있는 치료제 개발 및 백신 제조에 중요한 역할을 할 것으로 기대한다.

Keywords

References

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