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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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BioSMACK: a linux live CD for genome-wide association analyses

  • Hong, Chang-Bum (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Kim, Young-Jin (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Moon, Sang-Hoon (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Shin, Young-Ah (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Go, Min-Jin (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Kim, Dong-Joon (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Lee, Jong-Young (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health) ;
  • Cho, Yoon-Shin (Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health)
  • Received : 2011.08.05
  • Accepted : 2011.09.29
  • Published : 2012.01.31
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Abstract

Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools, during the installation of software. This is a huge obstacle to any research institute without computing facilities and specialists. Therefore, a proper research environment is an urgent need for researchers working on GWAS. We developed BioSMACK to provide a research environment for GWAS that requires no configuration and is easy to use. BioSMACK is based on the Ubuntu Live CD that offers a complete Linux-based operating system environment without installation. Moreover, we provide users with a GWAS manual consisting of a series of guidelines for GWAS and useful examples. BioSMACK is freely available at http://ksnp.cdc.go.kr/biosmack.

Keywords

References

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