Journal of Ginseng Research

  • 제36권1호
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  • Pages.61-67
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  • 2012
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts

  • Song, Kyu-Choon (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University) ;
  • Chang, Tong-Shin (Division of Life & Pharmaceutical Sciences, Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University) ;
  • Lee, Hye-Jin (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University) ;
  • Kim, Jin-Hee (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University) ;
  • Park, Jeong-Hill (College of Pharmacy, Seoul National University) ;
  • Hwang, Gwi-Seo (Lab of Cell Differentiation Research, College of Oriental Medicine, Gachon University)
  • 투고 : 2011.12.02
  • 심사 : 2011.12.29
  • 발행 : 2012.01.11
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초록

In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.

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참고문헌

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