Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Intracranial Extraskeletal Myxoid Chondrosarcoma : Case Report and Literature Review

  • Park, Jin Hoon (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Mi-Jung (Department of Neurological Pathology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Chang Jin (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jeong Hoon (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2012.01.05
  • Accepted : 2012.09.17
  • Published : 2012.09.28
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Abstract

Intracranial extraskeletal myxoid chondrosarcoma is extremely rare, with only seven patients previously reported. We present a case report of a 21-year-old woman admitted for weakness in her right extremities and symptoms of increased intracranial pressure. Magnetic resonance imaging (MRI) revealed hydrocephalus and a well-enhanced large mass around her left thalamus. A left parietal craniotomy and a cortisectomy at the superior parietal lobule were performed. Total surgical resection was also performed, and pathology results confirmed an extraskeletal myxoid chondrosarcoma. Postoperative MRI showed no residual tumor, and the patient underwent radiotherapy. After six months of radiotherapy, the patient's headache and weakness had improved to grade IV. This malignant tumor showed high rates of recurrence in previous reports. We here report another occurrence of this highly malignant and rare tumor in a patient treated using total surgical excision and adjuvant radiotherapy.

Keywords

References

  1. Bourgouin PM, Tampieri D, Robitaille Y, Robert F, Bergeron D, del Carpio R, et al. : J Comput Assist Tomogr 16 : 268-273, 1992 https://doi.org/10.1097/00004728-199203000-00017
  2. Chaskis C, Michotte A, Goossens A, Stadnik T, Koerts G, D'Haens J : Primary intracerebral myxoid chondrosarcoma. Case illustration. J Neurosurg 97 : 228, 2002 https://doi.org/10.3171/jns.2002.97.1.0228
  3. Cummings TJ, Bridge JA, Fukushima T : Extraskeletal myxoid chondrosarcoma of the jugular foramen. Clin Neuropathol 23 : 232-237, 2004
  4. Enzinger FM, Shiraki M : Extraskeletal myxoid chondrosarcoma. An analysis of 34 cases. Hum Pathol 3 : 421-435, 1972 https://doi.org/10.1016/S0046-8177(72)80042-X
  5. González-Lois C, Cuevas C, Abdullah O, Ricoy JR : Intracranial extraskeletal myxoid chondrosarcoma : case report and review of the literature. Acta Neurochir (Wien) 144 : 735-740, 2002 https://doi.org/10.1007/s00701-002-0949-y
  6. Grossman RI, Davis KR : Cranial computed tomographic appearance of chondrosarcoma of the base of the skull. Radiology 141 : 403-408, 1981 https://doi.org/10.1148/radiology.141.2.7291563
  7. Hassounah M, Al-Mefty O, Akhtar M, Jinkins JR, Fox JL : Primary cranial and intracranial chondrosarcoma. A survey. Acta Neurochir (Wien) 78 : 123-132, 1985 https://doi.org/10.1007/BF01808691
  8. Im SH, Kim DG, Park IA, Chi JG : Primary intracranial myxoid chondrosarcoma : report of a case and review of the literature. J Korean Med Sci 18 : 301-307, 2003 https://doi.org/10.3346/jkms.2003.18.2.301
  9. Korten AG, ter Berg HJ, Spincemaille GH, van der Laan RT, Van de Wel AM : Intracranial chondrosarcoma : review of the literature and report of 15 cases. J Neurol Neurosurg Psychiatry 65 : 88-92, 1998 https://doi.org/10.1136/jnnp.65.1.88
  10. O'Brien J, Thornton J, Cawley D, Farrell M, Keohane K, Kaar G, et al. : Extraskeletal myxoid chondrosarcoma of the cerebellopontine angle presenting during pregnancy. Br J Neurosurg 22 : 429-432, 2008 https://doi.org/10.1080/02688690701780127
  11. Oliveira AM, Sebo TJ, McGrory JE, Gaffey TA, Rock MG, Nascimento AG : Extraskeletal myxoid chondrosarcoma : a clinicopathologic, immunohistochemical, and ploidy analysis of 23 cases. Mod Pathol 13 : 900-908, 2000 https://doi.org/10.1038/modpathol.3880161
  12. Sala F, Talacchi A, Beltramello A, Iuzzolino P, Bricolo A : Intracranial myxoid chondrosarcoma with early intradural growth. J Neurosurg Sci 42 : 159-163, 1998
  13. Salcman M, Scholtz H, Kristt D, Numaguchi Y : Extraskeletal myxoid chondrosarcoma of the falx. Neurosurgery 31 : 344-348, 1992 https://doi.org/10.1227/00006123-199208000-00021
  14. Sato K, Kubota T, Yoshida K, Murata H : Intracranial extraskeletal myxoid chondrosarcoma with special reference to lamellar inclusions in the rough endoplasmic reticulum. Acta Neuropathol 86 : 525-528, 1993
  15. Scott RM, Dickersin R, Wolpert SM, Twitchell T : Myxochondrosarcoma of the fourth ventricle. Case report. J Neurosurg 44 : 386-389, 1976 https://doi.org/10.3171/jns.1976.44.3.0386
  16. Smith TW, Davidson RI : Primary meningeal myxochondrosarcoma presenting as a cerebellar mass : case report. Neurosurgery 8 : 577-581, 1981 https://doi.org/10.1227/00006123-198105000-00012
  17. Sorimachi T, Sasaki O, Nakazato S, Koike T, Shibuya H : Myxoid chondrosarcoma in the pineal region. J Neurosurg 109 : 904-907, 2008 https://doi.org/10.3171/JNS/2008/109/11/0904

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