Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Visceral fat and body weight are reduced in overweight adults by the supplementation of Doenjang, a fermented soybean paste

  • Cha, Youn-Soo (Department of Food Science and Human Nutrition, Obesity Research Center, Chonbuk National University) ;
  • Yang, Ji-Ae (Department of Food Science and Human Nutrition, Obesity Research Center, Chonbuk National University) ;
  • Back, Hyang-Im (Department of Food Science and Human Nutrition, Obesity Research Center, Chonbuk National University) ;
  • Kim, Soo-Ran (Department of Food Science and Human Nutrition, Obesity Research Center, Chonbuk National University) ;
  • Kim, Min-Gul (Clinical Trial Center for Functional Foods, Chonbuk National University Hospital) ;
  • Jung, Su-Jin (Clinical Trial Center for Functional Foods, Chonbuk National University Hospital) ;
  • Song, Won O (Department of Food Science and Human Nutrition, Michigan State University) ;
  • Chae, Soo-Wan (Clinical Trial Center for Functional Foods, Chonbuk National University Hospital)
  • Received : 2012.04.10
  • Accepted : 2012.10.03
  • Published : 2012.12.31
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Abstract

Various forms of fermented soybean products are well documented for their health benefits. The efficacy of anti-obesogenic effect of Doenjang, one of the most commonly used seasonings in Korean cuisine, has been reported only in animal models; thus, an evaluation of Doenjang needs to be conducted in human studies. We aimed to test the hypothesis that Doenjang supplementation reduces body weight and changes body composition in overweight adults. A total of 51 overweight adults participated in this study. A group of males with BMI ${\geq}23kg/m^2$ and waist to hip ratio (WHR) ${\geq}$ 0.90, and a group of females with BMI ${\geq}23kg/m^2$ and WHR ${\geq}$ 0.85 were randomly assigned to either a Doenjang supplement (9.9 g dry/day) group or a placebo group for a 12-week randomized, double-blind and placebo-controlled study. Anthropometric parameters, abdominal fat distribution by computerized tomography (CT) and blood components were measured before and after the intervention period. After the 12-week study, the Doenjang supplementation group had significant reductions in body weight (kg), body fat mass (kg) and body fat (%) compared to the placebo group, the supplementation of Doenjang resulted in a significant reduction in visceral fat ($cm^2$), although no changes were observed in total and subcutaneous fat are as ($cm^2$), serum lipid profiles and dietary intakes. The present study demonstrated that daily supplementation of 9.9 g dry/day of Doenjang for 12 weeks reduces body weight and visceral fat in overweight adults.

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References

  1. de Onis M, Blössner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 2010;92:1257-64. https://doi.org/10.3945/ajcn.2010.29786
  2. Jones-Smith JC, Gordon-Larsen P, Siddiqi A, Popkin BM. Crossnational comparisons of time trends in overweight inequality by socioeconomic status among women using repeated cross-sectional surveys from 37 developing countries, 1989-2007. Am J Epidemiol 2011;173:667-75. https://doi.org/10.1093/aje/kwq428
  3. Gonçalves FB, Koek M, Verhagen HJ, Niessen WJ, Poldermans D. Body-mass index, abdominal adiposity, and cardiovascular risk. Lancet 2011;378:227. https://doi.org/10.1016/S0140-6736(11)61121-5
  4. Velasquez MT, Bhathena SJ. Role of dietary soy protein in obesity. Int J Med Sci 2007;4:72-82.
  5. Kwon DY, Daily JW 3rd, Kim HJ, Park S. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res 2010;30:1-13. https://doi.org/10.1016/j.nutres.2009.11.004
  6. Namgung HJ, Park HJ, Cho IH, Choi HK, Kwon DY, Shim SM, Kim YS. Metabolite profiling of doenjang, fermented soybean paste, during fermentation. J Sci Food Agric 2010;90:1926-35.
  7. Kwon DY, Hong SM, Ahn IS, Kim MJ, Yang HJ, Park S. Isoflavonoids and peptides from meju, long-term fermented soybeans, increase insulin sensitivity and exert insulinotropic effects in vitro. Nutrition 2011;27:244-52. https://doi.org/10.1016/j.nut.2010.02.004
  8. Nakajima N, Nozaki N, Ishihara K, Ishikawa A, Tsuji H. Analysis of isoflavone content in tempeh, a fermented soybean, and preparation of a new isoflavone-enriched tempeh. J Biosci Bioeng 2005;100:685-7. https://doi.org/10.1263/jbb.100.685
  9. Kwak CS, Park SC, Song KY. Doenjang, a fermented soybean paste, decreased visceral fat accumulation and adipocyte size in rats fed with high fat diet more effectively than nonfermented soybeans. J Med Food 2012;15:1-9. https://doi.org/10.1089/jmf.2010.1224
  10. Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won Yoon J, Choi SH, Cho SI, Park KS, Lee HK, Jang HC, Koh KK. Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007. Diabetes Care 2011;34:1323-8. https://doi.org/10.2337/dc10-2109
  11. Lee MJ, Popkin BM, Kim S. The unique aspects of the nutrition transition in South Korea: the retention of healthful elements in their traditional diet. Public Health Nutr 2002;5:197-203.
  12. Song Y, Joung H. A traditional Korean dietary pattern and metabolic syndrome abnormalities. Nutr Metab Cardiovasc Dis 2012;22:456-62. https://doi.org/10.1016/j.numecd.2010.09.002
  13. Kim YS, Kim MC, Kwon SW, Kim SJ, Park IC, Ka JO, Weon HY. Analyses of bacterial communities in meju, a Korean traditional fermented soybean bricks, by cultivation-based and pyrosequencing methods. J Microbiol 2011;49:340-8. https://doi.org/10.1007/s12275-011-0302-3
  14. Park KY, Jung KO, Rhee SH, Choi YH. Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. Mutat Res 2003;523-524:43-53. https://doi.org/10.1016/S0027-5107(02)00320-2
  15. Aoki H, Furuya Y, Endo Y, Fujimoto K. Effect of gammaaminobutyric acid-enriched tempeh-like fermented soybean (GABATempeh) on the blood pressure of spontaneously hypertensive rats. Biosci Biotechnol Biochem 2003;67:1806-8. https://doi.org/10.1271/bbb.67.1806
  16. Jung KO, Park SY, Park KY. Longer aging time increases the anticancer and antimetastatic properties of doenjang. Nutrition 2006;22:539-45. https://doi.org/10.1016/j.nut.2005.11.007
  17. Fan J, Zhang Y, Chang X, Saito M, Li Z. Changes in the radical scavenging activity of bacterial-type douchi, a traditional fermented soybean product, during the primary fermentation process. Biosci Biotechnol Biochem 2009;73:2749-53. https://doi.org/10.1271/bbb.90361
  18. Chen YC, Sugiyama Y, Abe N, Kuruto-Niwa R, Nozawa R, Hirota A. DPPH radical-scavenging compounds from dou-chi, a soybean fermented food. Biosci Biotechnol Biochem 2005;69: 999-1006. https://doi.org/10.1271/bbb.69.999
  19. Choi J, Kwon SH, Park KY, Yu BP, Kim ND, Jung JH, Chung HY. The anti-inflammatory action of fermented soybean products in kidney of high-fat-fed rats. J Med Food 2011;14:232-9. https://doi.org/10.1089/jmf.2010.1039
  20. Yang JY, Lee SJ, Park HW, Cha YS. Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food 2006;9:459-67. https://doi.org/10.1089/jmf.2006.9.459
  21. Pyo YH, Seong KS. Hypolipidemic effects of Monascusfermented soybean extracts in rats fed a high-fat and -cholesterol diet. J Agric Food Chem 2009;57:8617-22. https://doi.org/10.1021/jf901878c
  22. Park JH, Ha AW, Cho JS. Effects of green tea-soybean paste on weights and serum lipid profiles in rats fed high fat diet. Korean J Food Sci Technol 2005;37:806-11.
  23. Kim S, Shin HJ, Kim SY, Kim JH, Lee YS, Kim DH, Lee MO. Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha. Mol Cell Endocrinol 2004;220:51-8. https://doi.org/10.1016/j.mce.2004.03.011
  24. Kwon SH, Lee KB, Im KS, Kim SO, Park KY. Weight reduction and lipid lowering effects of korean traditional soybean fermented products. J Korean Soc Food Sci Nutr 2006;35:1194-9. https://doi.org/10.3746/jkfn.2006.35.9.1194
  25. Gwak JH, Lee JH, Lee SJ, Park HW, Kim Y, Hyun YJ. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Korean J Nutr 2007;40:630-8.
  26. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D'Agostino RB Sr, O'Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116:39-48. https://doi.org/10.1161/CIRCULATIONAHA.106.675355
  27. Demerath EW, Reed D, Rogers N, Sun SS, Lee M, Choh AC, Couch W, Czerwinski SA, Chumlea WC, Siervogel RM, Towne B. Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 2008;88:1263-71.
  28. Wu J, Oka J, Tabata I, Higuchi M, Toda T, Fuku N, Ezaki J, Sugiyama F, Uchiyama S, Yamada K, Ishimi Y. Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J Bone Miner Res 2006;21:780-9. https://doi.org/10.1359/jbmr.060208
  29. Jang CH, Park CS, Lim JK, Kim JH, Kwon DY, Kim YS, Shin DH, Kim JS. Metabolism of isoflavone derivatives during manufacturing of traditional Meju and Doenjang. Food Sci Biotechnol 2008;17:442-5.
  30. Busby MG, Jeffcoat AR, Bloedon LT, Koch MA, Black T, Dix KJ, Heizer WD, Thomas BF, Hill JM, Crowell JA, Zeisel SH. Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr 2002;75:126-36. https://doi.org/10.1093/ajcn/75.1.126
  31. Sung JH, Choi SJ, Lee SW, Park KH, Moon TW. Isoflavones found in Korean soybean paste as 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors. Biosci Biotechnol Biochem 2004;68:1051-8. https://doi.org/10.1271/bbb.68.1051

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