Asian Pacific Journal of Cancer Prevention

  • 제13권12호
  • /
  • Pages.6217-6220
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  • 2012
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Between EGF, TGF-β1 and TNF-α Gene Polymorphisms and Hepatocellular Carcinoma

  • Shi, Hai-Zhou (Department of General Surgery, Binzhou Central Hospital, Binzhou medical College) ;
  • Ren, Peng (Department of General Surgery, Binzhou Central Hospital, Binzhou medical College) ;
  • Lu, Qing-Jun (Department of General Surgery, Binzhou Central Hospital, Binzhou medical College) ;
  • Niedrgethmnn, Marco (Surgical Clinic, University Hospital Mannheim) ;
  • Wu, Guo-Yang (Department of General Surgery, Zhongshan Hospital, Xiamen University)
  • 발행 : 2012.12.31
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초록

Introduction: Up to present, EGF $61^*A$/G, TGF-${\beta}1$-$509^*T$/C and TNF-${\alpha}$-$308^*A$/G gene polymorphisms have been analysed in other cancer entities than hepatocellular carcinoma (HCC). We here investigated the frequency of these gene polymorphisms among HCC patients. Materials and Methods: A total of 73 HCC patients and 117 cancer-free healthy people were recruited at the Surgical Department of Zhongshan Hospital. Genomic DNA was isolated from peripheral blood and gene polymorphisms were analyzed by PCR-RFLP. Results: The distribution of EGF $61^*G$/G homozygotes among HCC patients was more frequent than that in the control group (24.7% vs 11.1%, OR=2.618, 95%CI=1.195-5.738). In parallel, the frequency of the "G" allele in the HCC patient group was also higher than that in the control group (45.9% vs 33.3%, OR= 1.696, 95%CI=1.110-2.592). No difference could be found for the TGF-${\beta}1$-509 and TNF-${\alpha}$-308 genotypes. Conclusion: EGF $61^*G$/G genotype and G allele are significantly increased among patients with HCC. TGF-${\beta}1$-$509^*T$/C and TNF-${\alpha}$-$308^*A$/G gene polymorphisms are not related to this cancer entity.

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피인용 문헌

  1. A/G Polymorphism and Hepatocellular Carcinoma Risk: a Meta-Analysis vol.16, pp.7, 2015, https://doi.org/10.7314/APJCP.2015.16.7.3009
  2. Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma vol.8, pp.10, 2016, https://doi.org/10.4254/wjh.v8.i10.485
  3. Tumor Necrosis Factor-α-308 G/A Polymorphisms and Risk of Hepatocellular Carcinoma: A Meta-Analysis vol.inpress, pp.inpress, 2016, https://doi.org/10.5812/hepatmon.33537
  4. Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis vol.17, pp.11, 2013, https://doi.org/10.1089/gtmb.2013.0268
  5. Association between epidermal growth factor gene +61A/G polymorphism and the risk of hepatocellular carcinoma: a meta-analysis based on 16 studies vol.15, pp.1, 2015, https://doi.org/10.1186/s12885-015-1318-6