Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Molecular and Circulatory Expression of Insulin Growth Factors in Indian Females with Advanced Cervical Cancer

  • Sharma, Manoj (Department of Radiotherapy, Maulana Azad Medical College and Associated Lok Nayak Hospital) ;
  • Satyam, Abhigyan (Department of Biochemistry, All India Institute of Medical Sciences) ;
  • Abhishek, Ashu (Department of Radiotherapy, Maulana Azad Medical College and Associated Lok Nayak Hospital) ;
  • Khan, Rehan (Department of Biochemistry, All India Institute of Medical Sciences) ;
  • Rajappa, Medha (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research) ;
  • Sharma, Alpana (Department of Biochemistry, All India Institute of Medical Sciences)
  • Published : 2012.12.31
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Abstract

Background: Recent studies have demonstrated an association between insulin growth factor (IGF) and insulin growth factor binding protein-3 (IGFBP-III) serum levels and increased risk for various cancers. However, little information is available on clinical implications of the IGF system in Indian patients with cervical cancer. This study explored associations by analyzing their expression profiles in cervical cancer cases. Materials and Methods: Totals of 50 patients with advanced cervical cancer and 40 healthy controls were enrolled. Human papillomavirus (HPV) and cervical biopsy sample were obtained from all participating women. Circulatory levels were estimated by ELISA and the tissue expression was assessed using RT-PCR and Western blotting. Results: Levels of IGF-I and II showed significant increase whereas IGFBP-III showed significant decline in all patients as compared to controls. Spearman correlation analysis between IGFs and HPV status showed significant correlations. Conclusions: We demonstrated elevated circulating levels and tissue expression of IGF-I and IGF-II in advancer cancer cervix patients, as compared with controls, with a converse trend being apparent for IGFBP-III. In future, associations of the IGF system and clinical outcome of cervical cancer patients in post treatment samples might point to significance in disease mapping as a prognostic marker after validation with a larger patient series.

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References

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