Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Sclerotherapy of Multiple Intraoral Venous Malformations with Use of Ethanolamine Oleate: A Case Report

구강내 발생한 다발성 정맥기형 병소에의 Ethanolamine Oleate 경화제 주사 후 치험례

  • Kim, Tae-Kwang (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Yang, Jae-Young (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Choi, Seok-Tai (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Jeon, Hee-Kyung (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Leem, Dae-Ho (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Baek, Jin-A (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Shin, Hyo-Keun (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project) ;
  • Ko, Seung-O (Department of Oral and Maxillofacial Surgery, School of Dentistry, and Institute of Oral Bio-Science, Jeonbuk National University, Brain Korea 21 Project)
  • 김태광 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 양재영 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 최석태 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 전희경 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 임대호 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 백진아 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 신효근 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업) ;
  • 고승오 (전북대학교 치의학전문대학원 구강악안면외과학교실, 구강생체과학연구소, BK21사업)
  • Received : 2012.09.16
  • Accepted : 2012.11.23
  • Published : 2012.11.30
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Abstract

Hemangioma and vascular malformation are the most common benign tumors that are caused by congenitally or traumatic events. Theses tumors represent approximately 1/3~1/4 of all hemangiomas and vascular malformations in the head and neck. There are many forms of treatment for hemangioma and vascular malformation including closed observation, surgery, radiotherapy, laser therapy, steroid therapy, compression, embolization, and sclerotherapy. Ethanolamine oleate is an unsaturated fatty acid salt that has been used as a sclerosing agent because of its excellent thrombosing properties. This paper presents 1 case of intraoral multiple venous malformations treatment with 1.25% ethanolamine oleate (3.6~9.6 mg dose) intralesionally injected for 6 to 14 weeks over 2 week intervals. After the sclerotherapy, lesions almost completely disappeared without side effects. In conclusion, sclerotherapy using ethanolamine oleate is very effective against venous malformations, and sufficiently provides alternative support for surgical and other methods.

Keywords

References

  1. Watson WL, McCarthy WD. Blood and lymph vessel tumors. A report of 1056 cases. Surg Gynecol Obstet 1940;71:569-88.
  2. Wolff K, Goldsmith LA, Katz SI, et al., editors. Fitzpatrick's dermatology in general medicine. 7th ed. New York: McGraw Hill; 2008. p.1164.
  3. Neville BW, Damm DD, Allen CM, Bouqout JE, editors. Oral & maxillofacial pathology. 3rd ed. Philadelphia: W.B. Saunders; 2009. p.539-43.
  4. Lee EY, Kim KW, Lee JY. The treatment of hemangioma in lower lip. J Korean Assoc Maxillofac Plast Reconstr Surg 2010;32:373-7.
  5. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982;69:412-22. https://doi.org/10.1097/00006534-198203000-00002
  6. Tyagi I, Syal R, Goyal A. Management of low-flow vascular malformations of upper aero digestive system-role of N-butyl cyanoacrylate in peroperative devascularization. Br J Oral Maxillofac Surg 2006;44:152-6. https://doi.org/10.1016/j.bjoms.2005.04.005
  7. Baurmash H, DeChiara S. A conservative approach to the management of orofacial vascular lesions in infants and children: report of cases. J Oral Maxillofac Surg 1991;49:1222-5. https://doi.org/10.1016/0278-2391(91)90422-I
  8. Beckelheimer RG, Delzer DD. Hemangioma of the tongue. Gen Dent 1988;36:144-5.
  9. Madewell JE, Sweet DE. Tumors and tumor-like lesions in or about joints. In: Resnick D, Niwayama G, editors. Diagnosis of bone and joint disorders. Vol. 6. 3rd ed. Philadelphia: WB Saunders; 1995. p.3939-90.
  10. Zou ZJ, Wu YT, Sun GX, Zhu XP, Meng XZ, He ZQ. Clinical application of angiography of oral and maxillofacial hemangiomas. Clinical analysis of seventy cases. Oral Surg Oral Med Oral Pathol 1983;55:437-47. https://doi.org/10.1016/0030-4220(83)90226-8
  11. Sadeghi E, Gingrass D. Oral hemangioma treated with a sclerosing agent. Report of a case. Int J Oral Maxillofac Surg1989;18:262-3. https://doi.org/10.1016/S0901-5027(89)80089-X
  12. Chin DC. Treatment of maxillary hemangioma with a sclerosing agent. Oral Surg Oral Med Oral Pathol 1983;55:247-9. https://doi.org/10.1016/0030-4220(83)90322-5
  13. Johann AC, Aguiar MC, do Carmo MA, Gomez RS, Castro WH, Mesquita RA. Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: an open clinical trial with 30 lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:579-84. https://doi.org/10.1016/j.tripleo.2004.12.021
  14. Kim KW, Sang JK, Cheong JH. Sclerotherapy of benign oral vascular lesion with sodium tetradecyl sulfate: cases report. J Korean Assoc Oral Maxillofac Surg 2010;36:280-5. https://doi.org/10.5125/jkaoms.2010.36.4.280
  15. Nishida R, Inoue R, Takimoto Y, Kita T. A sclerosant with astringent properties developed in China for oesophageal varices: comparison with ethanolamine oleate and polidocanol. J Gastroenterol Hepatol 1999;14:481-8.
  16. Yakes WF, Rossi P, Odink H. How I do it. Arteriovenous malformation management. Cardiovasc Intervent Radiol 1996;19:65-71. https://doi.org/10.1007/BF02563895
  17. Choi YH, Han MH, O-Ki K, Cha SH, Chang KH. Craniofacial cavernous venous malformations: percutaneous sclerotherapy with use of ethanolamine oleate. J Vasc Interv Radiol 2002;13:475-82. https://doi.org/10.1016/S1051-0443(07)61527-9
  18. Connor WE, Hoak JC, Warner ED. Massive thrombosis produced by fatty acid infusion. J Clin Invest 1963;42:860-6. https://doi.org/10.1172/JCI104778
  19. Bordas JM, Feu F, Vilella A, Rodes J. Anaphylactic reaction to ethanolamine oleate injection in sclerotherapy of esophageal varices. Endoscopy 1989;21:50. https://doi.org/10.1055/s-2007-1012897
  20. Matsumoto K, Nakanishi H, Koizumi Y, Seike T, Kanda I, Kubo Y. Sclerotherapy of hemangioma with late involution. Dermatol Surg 2003;29:668-71. https://doi.org/10.1046/j.1524-4725.2003.29159.x