Anti-fatigue and Hepatoprotective Effects of Fermented Antler

발효녹용의 항피로 및 간장보호 효과

  • Received : 2011.12.20
  • Accepted : 2012.02.24
  • Published : 2012.03.31

Abstract

To increase the extraction yield and biological effect of antler by fermentation, probiotics fermenting antler were screened from rice shells. Of screened Bacillus species, the most potently antler-degrading probiotics was Bacillus KH-07. The supernatant yield of fermented antler is highest. Bacillus KH-07 may belong to Bacillus licheniformis by biochemical and 16S rDNA sequencing analyses. The KH-07-fermented antler (50 mg/kg) increased the anti-fatigue effect 2.3-fold compared to that of non-treated antler. Furthermore, the KH-07-fermented antler improved $CCl_4$-induced liver injury in mice. Based on these findings, the extraction yield and biological effect of antler can be increased by KH-07 fermentation.

Keywords

References

  1. 한방약리학 교재편찬위원회 (2010) 한방약리학 (제 3판) 692-694.
  2. 용재익 (1961) 녹용에 관한 연구. Cholesterol 투여 가토의 혈청중 cholesterol에 미치는 녹용의 영향. 약학회지 5: 6-19.
  3. 용재익 (1964) 실험적 가토 빈혈에 미치는 녹용투여의 영향. 약학회지 8: 6-15.
  4. 신국현 이은방, 김재현, 정명숙, 조성익 (1989) 분말녹용의 약물활성 연구. 생약학회지 20: 180-187.
  5. Wang, B. X., Zhao, X. H., Qi, S. B., Yang, X. W., Kaneko, S., Hattori, M., Namba, T. and Nomura, Y. (1988) Stimulating effect of deer antler extract on protein synthesis in senescence- accelerated mice in vivo. Chem. Pharm. Bull. 36: 2593-2598. https://doi.org/10.1248/cpb.36.2593
  6. Wang, B. X., Zhao, X. H., Qi, S. B., Kaneko, S., Hattori, M., Namba, T. and Nomura, Y. (1988) Effects of repeated administration of deer antler extract on biochemical changes related to aging in senescence-accelerated mice. Chem. Pharm. Bull. 36: 2587-92. https://doi.org/10.1248/cpb.36.2587
  7. Huang, S. L., Kakiuchi, N., Hattori, M. and Namba, T. (1991) A new monitoring system of cultured myocardial cell motion: effect of pilose antler extract and cardioactive agents on spontaneous beating of myocardial cell sheets. Chem. Pharm. Bull. 39: 384-387. https://doi.org/10.1248/cpb.39.384
  8. 김동현, 한상법, 박주석, 한명주 (1994) 발효녹용의 생리활성. 생약학회지 25: 233-237.
  9. 김동현, 한상범, 유기웅, 김유숙, 한명주 (1994) 복수암 생쥐에 대한 발효녹용의 항암효과 38: 795-799.
  10. Smeath, P. H. A., Mair, N. S., Sharpe, M. E. and Holt, J. G. (1986) Bergey's Manual of Systemic Bacteriology. 2, 1105, Williams & Wilkins, Baltimore.
  11. 신용욱, 최혁재, 김동현, 박정일, 김남재 (2006) 가공인삼의 항피로효과. 동서의학연구소 논문집 13: 219-225.
  12. 최혁재, 한명주, 백남인, 김동현, 정해곤, 김남재 (2006) 순문의 D-galactosamine 유발 간장해 보호효과. 생약학회 37: 258-265.