Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Differential Anti-Carcinogenic Effect of Mountain Cultivated Ginseng and Ginseng on Mouse Skin Carcinogenesis

마우스 피부암에 대한 장뇌삼과 인삼의 특이적 항암 효능

  • Lee, Min-Hee (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Choi, Sang-Won (Dept. of Food Science and Nutrition, Catholic University of Daegu) ;
  • Kim, Eun-Jung (Dept. of Food Science and Nutrition, Catholic University of Daegu)
  • 이민희 (대구가톨릭대학교 식품영양학과) ;
  • 최상원 (대구가톨릭대학교 식품영양학과) ;
  • 김은정 (대구가톨릭대학교 식품영양학과)
  • Received : 2011.09.15
  • Accepted : 2012.03.15
  • Published : 2012.04.30
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Abstract

Mountain cultivated ginseng (MCG) is a type of Panax ginseng C. A. Mayer, grown in the mountains by artificial seeding. In general, it has been known that the biophysical activities of MCG is greater than that of ginseng. However, the in vivo efficacy of MCG on cancer has not been studied. In this study, we investigated the anti-carcinogenic effect of MCG and ginseng using the 7,12-dimethylbenz[a]anthracene (DMBA)-12-O-tetradecanoylphorbol- 13-acetate (TPA) two stage mouse skin carcinogenesis model. Six weeks of female ICR mice were divided into control, MCG, and ginseng diet groups and were subjected into two different experimental protocols. In the first study, each experimental diet was fed with TPA promotion for 24 weeks. The result showed that supplementation of MCG reduced tumor incidence, tumor multiplicity, and tumor size compared to those of the control and ginseng groups. In the second study, 3 groups of mice were supplied with each diet 4 weeks before DMBA tumor initiation, until the end of experiment. The result showed that tumor incidence, tumor multiplicity, and tumor size were reduced in the ginseng diet group compared to those of the control and MCG groups. TPA-induced BrdU incorporation was also significantly reduced in the ginseng diet group. Taken together, these results suggest that MCG is chemotherapeutic, whereas ginseng has a chemopreventative effect on mouse skin cancer.

본 연구의 결과, TPA 종양촉진 시작과 함께 실험식이를 급여하였을 때, 장뇌삼은 대조군과 인삼군보다 낮은 피부종양발생수를 나타내었으며 종양발생률에서도 대조군과 인삼군에 비해 장뇌삼군에서 종양의 발생이 지연되는 것으로 나타났다. 반면, DMBA 종양개시 한 달 전부터 실험 종료 시까지 실험식이를 급여하였을 때는 대조군과 장뇌삼군에 비해 인삼군의 종양발생수가 감소된 것으로 나타나 인삼은 암 예방효능이 장뇌삼보다 더 높은 것으로 나타났다. 장뇌삼과 인삼은 마우스 피부암이 아닌 다른 상피세포성 암에 대해서도 각각 이러한 효능을 보일 것인지에 대해서 후속연구가 요구되며 또한 앞으로 인삼과 장뇌삼의 유효성분을 발굴하고 이를 더욱 효과적으로 섭취할 수 있는 방법이 개발되어야 할 것으로 생각된다. 아울러 질적으로 우수한 우리나라 장뇌삼과 인삼이 건강기능식품으로서 뿐만 아니라 암 예방과 암치료에 사용될 수 있는 대체의약품으로 개발되기 위해서는 실질적인 임상치료 연구와 더불어 보다 구체적인 과학적 기능 규명연구가 필요하다고 생각된다.

Keywords

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