Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Diets with Red Yeast Sweet Potato Powder Supplement on Fecal Amount and Lipid Metabolism in Rats Fed a High-fat Diet

홍국고구마가 고지방식이를 급여한 흰쥐의 배변량 및 지질대사에 미치는 영향

  • Received : 2012.01.03
  • Accepted : 2012.01.26
  • Published : 2012.04.30
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Abstract

This study was performed to investigate the effects of a diet with a red yeast sweet potato supplement on fecal amount and lipid metabolism in male Sprague-Dawley rats fed a high-fat diet for 10 weeks. Rats were fed a high-fat diet (15% fat) with additional lard (7%) and cholesterol (1%) based on AIN-93G basal diet (7% fat) for 6 weeks during the first phase. In the second phase, which lasted 4 weeks, the rats divided into four experimental groups which were composed of a high-fat diet group as a control (CON), a high-fat diet with 5% white-fleshed sweet potato supplement group (WFSP), a high-fat diet with 5% red yeast sweet potato supplement group (RYSP), and a high-fat diet with 5% purple-fleshed sweet potato supplement group (PFSP). The fecal amount of group RYSP increased significantly during the second phase compared to the other groups (p<0.05). The fecal total cholesterol (TC) and triglyceride (TG) content of group RYSP were also highest among all experimental groups. The serum TC and TG were shown to have the lowest levels in the group RYSP, and LDL-cholesterol levels were significantly decreased in groups RYSP and PFSP than in group CON (p<0.05). These results indicate that supplementation with red yeast sweet potato seemed to be effective in increasing feces and fecal lipid excretion, and also in decreasing serum lipid levels in rats fed a high-fat diet.

홍국고구마가 고지방식이를 섭취한 흰쥐의 배변량 및 지질대사 개선에 미치는 영향을 조사하고자 SD계 수컷 흰쥐를 대상으로 실험 1기(6주)에 고지방식이를 급여하고, 실험 2기(4주)에 3종의 고구마분말(일반, 홍국, 자색)을 5% 첨가한 식이를 급여했을 때, 배변량은 홍국고구마군(RYSP)이 고지방대조군(CON)에 비해 유의하게 증가하였고(p<0.05), 장 통과시간 역시 RYSP군이 가장 짧았다. 분변 중 총콜레스테롤(TC) 함량은 일반고구마군(WFSP)과 홍국고구마군(RYSP)이 유의하게 높았고(p<0.05), 그중에서도 RYSP군이 더 높은 함량을 나타내었으며, 중성지방(TG) 농도는 RYSP군이 WFSP군과 PFSP(자색고구마)군에 비해 각각 9%, 26% 더 높았으나 유의성은 없었다. 반면 1일 총 지질배설량은 TC와 TG 모두 RYSP군이 CON군과 PFSP군에 비해 유의적으로 높았다(p<0.05). 혈청 중 TC 농도는 RYSP군이 CON군에 비해 유의적 차이 없이 20% 감소하였고, LDL-C 농도는 RYSP, PFSP군이 CON군보다 통계적으로 유의하게 낮았으며(p<0.05), TG 농도는 RYSP군이 실험군중 가장 낮았고 이는 WFSP군과 유의적인 차이가 있었다(p<0.05). 이상의 결과에서 홍국고구마 식이는 배변량을 증가시키고, 분변 중 지질 배설량을 다소 증가시키며, 혈청 지질 농도의 감소 효과를 확인할 수 있었다.

Keywords

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