DOI QR코드

DOI QR Code

레이저 유도방식의 실시간 광음향 단층영상 기술 개발과 팬텀이미지 평가

Development of Laser Induced Real Time Photoacoustic Tomography Imaging System and Phantom Evaluation

  • 유상훈 (전북대 공대 전자공학부) ;
  • 신동호 (전북대 공대 전자공학부) ;
  • 송철규 (전북대 공대 전자공학부, 영상정보신기술연구센터)
  • 투고 : 2012.04.16
  • 심사 : 2012.05.15
  • 발행 : 2012.06.01

초록

Photoacoustic Tomography (PAT) is a promising medical imaging modality by reason of its particularity. It combines optical imaging contrast of optical imaging with the spatial resolution of ultrasound imaging and can demonstrate change of biological feature in an image. For that reason, many studies are in progress to apply this technic for diagnosis. But, real-time PAT system is necessary to confirm a biological reaction induced by external stimulation immediately. Thus, we developed a real-time PAT system using linear array transducer and self-developed Data acquisition board (DAQ) resources, To evaluate the feasibility and performance of our proposed system, two type of phantom test were also performed. As a result of those experiments, the proposed system shows enough performance and confirm its usefulness.

키워드

참고문헌

  1. A. Oraevsky and A. Karabutov, "Optoacoustic tomography," in Biomedical Photonics Handbook, T. Vo-Dinh, Ed., Chap. 34, pp. 1-34, CRC, Boca Raton, FL 2003.
  2. L. V. Wang and H. Wu, Biomedical Optics:Principles and Imaging, Wiley, Hoboken, NJ 2007.
  3. Lihong V. Wang, Ed. Photoacoustic Imaging and Spectroscopy, 1st ed., CRC Press, Boca Raton, FL 2009.
  4. J. T. Oh, M. L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, "Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy," J. Biomed. Opt. 11(3), 34032, 2006. https://doi.org/10.1117/1.2210907
  5. R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoica, and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed. Opt. 12(1), 010501 (2007). https://doi.org/10.1117/1.2709850
  6. X. Wang, D. L. Chamberland, and D. A. Jamadar, ""Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis," Opt. Lett. 32(20), 3002-3004, 2007. https://doi.org/10.1364/OL.32.003002
  7. S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, "The Twente Photoacoustic Mammoscope: system overview and performance," Phys. Med. Biol. 50(11), 2543-2557, 2005. https://doi.org/10.1088/0031-9155/50/11/007
  8. S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, "Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies," Proc. SPIE 6856, 68560T, 2008.
  9. S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, ""Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography,"" Med. Phys. 34(8), 3294-3301 2007. https://doi.org/10.1118/1.2757088
  10. E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, ""In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,"" Phys. Med. Biol. 54(4), 1035-1046, 2009. https://doi.org/10.1088/0031-9155/54/4/014
  11. Zhou Q, Ji X, Xing D., "Full-field 3D photoacoustic imaging based on plane transducer array and spatial phase-controlled algorithm," Med. Phys. 38, 3, March 2011
  12. John Gamelin, Anastasios Maurudis, Andres Aguirre, Fei Huang, Puyun Guo, Lihong V. Wang, and Quing Zhu, "A real-time photoacoustic tomography system for small animals," OPTICS EXPRESS 10489, Vol. 17, No. 13, 22 June 2009 https://doi.org/10.1364/OE.17.010489
  13. M. Xu and L. V. Wang, "Universal back-projection algorithm for photoacoustic-computed tomography," Physical Review E71, 2005
  14. Changhui Li, Andres Aguirre, John Gamelin, Anastasios Maurudis, Quing Zhu, and Lihong V. Wang, "Real-time photoacoustic tomography of cortical hemodynamics in small animals," Journal of Biomedical Optics, Vol. 15, February 2010