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Recent Research on Treatments of Atopic Dermatitis in Japan - Within Diet and Kampo Medicine -

일본의 아토피피부염 치료에 대한 최신연구 동향 -식품, 화한의학(和漢醫學) 중심으로-

  • Ha, Na-Lee (Pusan National University School of Korean Medicine) ;
  • Lee, Jang-Cheon (Pusan National University School of Korean Medicine) ;
  • Kim, Ki-Bong (Pusan National University School of Korean Medicine)
  • 하나리 (부산대학교 한의학전문대학원) ;
  • 이장천 (부산대학교 한의학전문대학원) ;
  • 김기봉 (부산대학교 한의학전문대학원)
  • Received : 2012.01.26
  • Accepted : 2012.02.17
  • Published : 2012.02.28

Abstract

Objectives The purpose of this study is to investigate various treatments in Japan for atopic dermatitis. The treatments on atopic dermatitis from diet modification and kampo medicine were studied for 11 years (from 2001 to 2011). Methods The search database includes PubMed. To narrow the search, the following key search terms were used: 'atopic dermatitis, diet, japan', 'atopic dermatitis, kampo, japan'. The search was limited to the publication date from 2001 to 2011. Results 1. There are 16 studies on atopic dermatitis treatment by using diets - 2 clinical trials and 12 animal experiments. All researches have revealed that diet modification is effective for atopic dermatitis. 2. There are 6 studies on atopic dermatitis treatment by using kampo medicine - 2 clinical trials and 4 animal experiments. All researches have revealed that kampo medicine is effective for atopic dermatitis. 3. There are 4 studies on atopic dermatitis treatment by using herbs - 4 animal experiments. All researches have revealed that herb is effective for atopic dermatitis. Conclusions Most of the animal experiments were using mice, so the studies on safety and effectiveness are needed to be confirmed to human as well. In the future, systematic guidelines and protocols are necessary for clinical trials and development of successful treatments on atopic dermatitis is needed.

Acknowledgement

Supported by : 부산대학교병원

References

  1. 박영립. 아토피피부염에서 보습제 사용. 한국 피부장벽학회지. 2007:37-40.
  2. 오재원, 김규언, 편복양, 이혜란, 정지태, 홍수종, 박강서, 이수영, 송상욱, 김철횽, 안강모, 남승연, 손명현, 김우경, 이미희, 권병철, 최성연, 이소연, 이하백, 이상일, 이준성. 1995년과 2000년의 학동기와 2003년 학동전기 소아에서의 아토피피부염의 역학적 변화에 관한 전국적인 연구. 소아알레르기 및 호흡기 학회지. 2003;13(4):227-37.
  3. 연세대학교의과대학 피부과학교실. 아토피 통계자료. 대한피부과학회 추계학술대회. 2006;48(8):92-3.
  4. 조백건, 이진용, 김덕곤. 내소화중탕가미방(內消和中湯加味方)의 아토피피부염 치료에 대한 임상적 고찰. 대한한방소아학회지. 2005;13(4):227-37.
  5. 上海中醫學院篇. 中醫外科學. 上海:商務印書館. 1981:101-5.
  6. 顧伯華. 實用中醫外科學. 上海:上海科學技術出版社. 1985:454-9, 461-4.
  7. Furue M, Furukawa F, Hide M, Takehara K. Guidelines for therapy for atopic dermatitis 2003. Jpn J Dermatol. 2003;113:451-7 (in Japanese).
  8. Baron ED, Barzilai D, Johnston G, Kawashima M, Takigawa M, Nakagawa H, et al. Atopic dermatitis management: comparing the treatment patterns of dermatologists in Japan, U.S.A. and U.K. Br J Dermatol. 2002;147:710-5. https://doi.org/10.1046/j.1365-2133.2002.04895.x
  9. Kobayashi H, Mizuno N, Teramae H, Kutsuna H, Ueoku S, Onoyama J, et al. Diet and Japanese Herbal Medicine for recalcitrant atopic dermatitis: Efficacy and safety of the treatment. Int J Drugs Exp Clin Res. 2004;30(5-6):197-202.
  10. Goto K, Iwasawa D, Kamimura Y, Yasuda M, Matsumura M, Shimada T. Clinical and histopathological evaluation of dermatophagoides farinae-induced dermatitis in NC/Nga mice orally administered Bacillus subtilis. J Vet Med Sci. 2011 May;73(5):649-54. https://doi.org/10.1292/jvms.10-0457
  11. Watanabe T, Hamada K, Tategaki A, Kishida H, Tanaka H, Kitano M, Miyamoto T. Oral administration of lactic acid bacteria isolated from traditional South Asian fermented milk 'dahi' inhibits the development of atopic dermatitis in NC/Nga mice. J Nutr Sci Vitaminol (Tokyo). 2009 Jun;55(3):271-8. https://doi.org/10.3177/jnsv.55.271
  12. Hayashi A, Kimura M, Nakamura Y, Yasui H. Anti-atopic dermatitis effects and the mechanism of lactic acid bacteria isolated from Mongolian fermented milk. J Dairy Res. 2009 May;76(2):158-64. https://doi.org/10.1017/S0022029908003725
  13. Matsumoto J, Ishikawa S, Doi M, Kishida T, Ebihara K. Protease-resistant fraction of smoked, dried bonito alleviates atopic dermatitis-like skin lesions in NC/Nga mice. J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):451-6. https://doi.org/10.3177/jnsv.53.451
  14. Ukawa Y, Izumi Y, Ohbuchi T, Takahashi T, Ikemizu S, Kojima Y. Oral administration of the extract from Hatakeshimeji (Lyophyllum decastes sing.) mushroom inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. J Nutr Sci Vitaminol (Tokyo). 2007 Jun;53(3):293-6. https://doi.org/10.3177/jnsv.53.293
  15. Shimizu N, Dairiki K, Ogawa S, Kaneko T. Dietary whey protein hydrolysate suppresses development of atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice. Allergol Int. 2006 Jun;55(2):185-9. https://doi.org/10.2332/allergolint.55.185
  16. Taniguchi Y, Kohno K, Inoue S, Koya-Miyata S, Okamoto I, Arai N, Iwaki K, Ikeda M, Kurimoto M. Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol. 2003 Sep;3(9):1313-24. https://doi.org/10.1016/S1567-5769(03)00132-2
  17. Uehara M, Sugiura H, Sakurai K. A trial of oolong tea in the management of recalcitrant atopic dermatitis. Arch Dermatol. 2001 Jan;137(1):42-3.
  18. Iguchi T, Kawata A, Watanabe T, Mazumder TK, Tanabe S. Fermented barley extract suppresses the development of atopicdermatitis-like skin lesions in NC/Nga mice, probably by inhibiting inflammatory cytokines. Biosci Biotechnol Biochem. 2009 Mar 23;73(3):489-93. https://doi.org/10.1271/bbb.80436
  19. Hokazono H, Omori T, Ono K. Effects of single and combined administration of fermented barley extract and gamma-aminobutyric acid on the development of atopic dermatitis in NC/Nga mice. Biosci Biotechnol Biochem. 2010;74(1):135-9. https://doi.org/10.1271/bbb.90653
  20. Sakai T, Ire AV, Matoba T, Yamamoto S. Dietary trans fatty acids suppress the development of spontaneous atopic- like dermatitis in NC/Nga mice. J Nutr Sci Vitaminol (Tokyo). 2009;55(5):412-6. https://doi.org/10.3177/jnsv.55.412
  21. Nagai M, Okunishi I. The effect of wasabi rhizome extract on atopic dermatitis-like symptoms in HR-1 hairless mice. J Nutr Sci Vitaminol (Tokyo). 2009 Apr;55(2): 195-200. https://doi.org/10.3177/jnsv.55.195
  22. Kimata H. Improvement of atopic dermatitis and reduction of skin allergic responses by oral intake of konjac ceramide. Pediatr Dermatol. 2006 Jul-Aug;23(4):386-9. https://doi.org/10.1111/j.1525-1470.2006.00268.x
  23. Shinomiya F, Hamauzu Y, Kawahara T. Anti-allergic effect of a hot-water extract of quince (Cydonia oblonga). Biosci Biotechnol Biochem. 2009 Aug;73(8):1773-8. https://doi.org/10.1271/bbb.90130
  24. Ogawa K, Takeuchi M, Nakamura N. Immunological effects of partially hydrolyzed arabinoxylan from corn husk in mice. Biosci Biotechnol Biochem. 2005 Jan;69(1):19-25. https://doi.org/10.1271/bbb.69.19
  25. Fan W, Kouda K, Nakamura H, Takeuchi H. Effects of dietary restriction on spontaneous dermatitis in NC/Nga mice. Exp Biol Med (Maywood). 2001 Dec;226(11): 1045-50. https://doi.org/10.1177/153537020122601112
  26. Jiang J, Yamaguchi T, Funakushi N, Kuhara T, Fan PS, Ueki R, Suto H, Kase Y, Ikeda S, Ogawa H. Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice. J Dermatol Sci. 2009 Oct;56(1):37-42. https://doi.org/10.1016/j.jdermsci.2009.07.003
  27. Funakushi N, Yamaguchi T, Jiang J, Imamura S, Kuhara T, Suto H, Ueki R, Kase Y, Kobayashi H, Ogawa H, Ikeda S. Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice. Arch Dermatol Res. 2011 Nov;303(9):659-67. https://doi.org/10.1007/s00403-011-1137-9
  28. Kobayashi H, Mizuno N, Teramae H, Kutsuna H, Ueoku S, Onoyama J, Yamanaka K, Fujita N, Ishii M. Diet and Japanese herbal medicine for recalcitrant atopic dermatitis: efficacy and safety. Drugs Exp Clin Res. 2004;30(5-6):197-202.
  29. Kobayashi H, Ishii M, Takeuchi S, Tanaka Y, Shintani T, Yamatodani A, Kusunoki T, Furue M. Efficacy and Safety of a Traditional Herbal Medicine, Hochu-ekki-to in the Long-term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicenter, Double-blind, Randomized, Placebo-controlled Study. Evid Based Complement Alternat Med. 2010 Sep;7(3):367-73. https://doi.org/10.1093/ecam/nen003
  30. Gao XK, Fuseda K, Shibata T, Tanaka H, Inagaki N, Nagai H. Kampo Medicines for Mite Antigen-Induced Allergic Dermatitis in NC/Nga Mice. Evid Based Complement Alternat Med. 2005 Jun;2(2):191-9. https://doi.org/10.1093/ecam/neh077
  31. Makino T, Hamanaka M, Yamashita H, Mizukami H. Effect of bakumijiogan, an herbal formula in traditional Chinese medicine, on atopic dermatitis-like skin lesions induced by mite antigen in NC/Jic mice. Biol Pharm Bull. 2008 Nov;31(11):2108-13. https://doi.org/10.1248/bpb.31.2108
  32. Jiang S, Nakano Y, Rahman MA, Yatsuzuka R, Kamei C. Effects of a Dictamnus dasycarpus T. extract on allergic models in mice. Biosci Biotechnol Biochem. 2008 Mar;72(3):660-5. https://doi.org/10.1271/bbb.70050
  33. Jiang S, Nakano Y, Yatsuzuka R, Ono R, Kamei C. Inhibitory effects of Moutan cortex on immediate allergic reactions. Biol Pharm Bull. 2007 Sep;30(9):1707-10. https://doi.org/10.1248/bpb.30.1707
  34. Yamaguchi-Miyamoto T, Kawasuji T, Kuraishi Y, Suzuki H. Antipruritic effects of Sophora flavescens on acute and chronic itch-related responses in mice. Biol Pharm Bull. 2003 May;26(5):722-4. https://doi.org/10.1248/bpb.26.722
  35. Matsumoto M, Kotani M, Fujita A, Higa S, Kishimoto T, Suemura M, Tanaka T. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br J Dermatol. 2002 Feb;146(2):221-7. https://doi.org/10.1046/j.1365-2133.2002.04557.x
  36. Bohme M, Svenson A, Kull I, Nordvall S.L, Wahlgren C.F. Clinical features of atopic dermatitis at two years of age. A prospective, population-based case-control study. Acta Derm Venerol. 2001(81):193-7. https://doi.org/10.1080/000155501750376294
  37. 윤대철, 김희택, 김이화, 호동수. 아토피피부염 환자에서 黃連解毒湯이 함유된 한방화장품에 대한 임상 연구. 동의생리병리학회지 2008;22(6):1611-20.
  38. 유한정, 이진용, 김덕곤. 내소화중탕가미방이 아토피피부염 환아의 혈중 cytokine 분비에 미치는 영향. 대한한방소아과학회지. 2006;20(2):15-29.
  39. 허인희, 홍성민, 엄유식, 변학성, 심성용, 김경준. 외치요법을 위주로 한 아토피피부염 환자 증례. 한방안이비인후피부과학회지. 2006;19(3):201-8.
  40. Leung DYM. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol. 2000;105:860-76. https://doi.org/10.1067/mai.2000.106484
  41. Kobayashi H, Takahashi K, Mizuno N, Kutsuna H, Ishii M. An Alternative Approach to Atopic Dermatitis: Part I-Case-Series Presentation. eCAM. 2004;1(1):49-62.
  42. 유화성, 한성수, 김정순, 조총환, 이연월, 박상용, 이수진. 다섯 가지 버섯 추출물 수용액의 항전이와 면역조절 활성. 대한한의학회지. 2009;30(3):61-9.
  43. 박지수, 김윤희. 아토피 환자의 식이요법 및 외용요법의 조사와 체질별 적용. 대한한방소아과학회지. 2003;17(2):85-101.
  44. 공남미, 지선영. 아토피피부염의 양․한방적 고찰. 대한외관과학회지. 1999;12(1):241-53.
  45. 薛鎧. 保嬰全書. 台北:新文豊出版公社. 1977:252-56.
  46. 吳謙. 醫宗金鑒(下). 北京:人民衛生出版社. 1982: 443-4.
  47. 上海中醫學院附屬曙光醫院. 中醫兒科臨床手冊. 上海:上海科學技術出版社. 1986:103-4.
  48. 김미정, 이승연. 소아 아토피피부염에 대한 문헌적 고찰. 대한한방소아과학회지. 2000;14(2):169-84.
  49. Ikezawa Y. Recent progress and topics in diet therapy and nutrition therapy. 19. Allergic disease: Focused on atopic dermatitis. Clin Nutr. 1993;83:515-26 (in Japanese).
  50. 김정원. 알레르기 및 면역학적 관점에서의 아토피피부염. 대한피부과학회지. 2003;41(6):687-9.
  51. 김정희. 아토피피부염의 최신지견. 소아알레르기 및 호흡기학회지 2004;14(1):12-23.
  52. 한국 전통지식 포탈. Accessed online December 6, 2007. at: http://koreantk.com/servlet/PrescriptDetailServlet?cmd=1&pr e_cd=P0014156&s ear chGbn=pr escript&view_type=kor
  53. 박동일, 박봉규, 김원일. 十全大補湯이 알레르기반응에 미치는 영향. 동의생리병리학회지. 2003;17(2):308-15.
  54. 鞠潤範, 金相贊, 朴宣東, 朴性奎, 徐富一, 徐榮培, 申舜植, 李尙仁, 李長泉, 李棣 鄭宗佶, 朱榮丞, 崔湖榮. 方劑學. 서울:永林社. 2008:439-40.
  55. 박성남, 정혁상, 이진용. 消風散이 BALB/c mouse를 이용한 atopy 피부염 model에 미치는 영향. 경희의학. 2004;20:129-41.
  56. 류지철, 이재근, 구세광, 지선영. 소풍산 추출물이 수동 피부 아나필락시스(1형 알러지 피부염)에 미치는 효과. 한방안이비인후피부과학회지. 2009;22(3):1-10.
  57. 이인수, 김희택, 이은용, 김이화, 류주현. 황련해독탕의 사람 비점막 섬유아세포 IL-8 분비에 대한 효과. 대한안이비인후피부과학회지. 2003;16(3):68-81.
  58. 김보애, 김미소, 강보미, 변선희, 박일향, 박지하, 정지욱, 안은미, 정현아, 장정희, 배원, 이하영, 최필녀, 박찬익. 황련해독탕이 NC/Nga mice에서 유발된 아토피피부염에 미치는 영향. 대한본초학회지. 2008;23 (2):59-65.
  59. 전국한의과대학 본초학공동교재 편집위위원회. 본초학. 永林社. 2004:225-405.
  60. Eun-Rhan Woo, Jong Hwan Kwak., Hyoung Ja Kim. and Hokoon Park.: A new prenylated Flavonol from the roots of Sophora flavescens. J. Nat. Prod. 1998;61: 1552-4. https://doi.org/10.1021/np980103j
  61. 우무륜, 구영선, 김동희. 고삼(苦蔘)이 알러지성 염증반응에 미치는 영향. 대전대학교 한의학연구소 논문집. 2009;15(2):135-48.
  62. 이석원, 김동희, 설인찬, 김성훈. 목단피 추출물 및 EA분획의 항알러지 작용에 대한 연구. 대한동의생리병리학회지. 2001;15(4):631-53.
  63. 한의부인과학 편찬위원회. 한의부인과학(상). 서울: 정담. 2001:359-99.
  64. 안덕균. 한국본초도감. 서울:교학사. 1999:460.

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