Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Concurrent Weekly Docetaxel Chemotherapy in Combination with Radiotherapy for Stage III and IVA-B Nasopharyngeal Carcinoma

  • Wei, Wei-Hong (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Cai, Xiu-Yu (Department of Medical Oncology, State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University) ;
  • Xu, Tao (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Zhang, Guo-Yi (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Wu, Yong-Feng (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Feng, Wei-Neng (Department of Medical Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Lin, Li (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Deng, Yan-Ming (Department of Medical Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Lu, Qiu-Xia (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University) ;
  • Huang, Zhe-Li (Department of Radiation Oncology, First People's Hospital of Foshan Affiliated to Sun Yat-sen University)
  • Published : 2012.03.31
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Abstract

Background and Purpose: Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. Methods and Materials: Eighty-four patients with Stage III and IVA-B NPCs, treated between 2007 and 2008, were retrospectively analyzed. Thirty received weekly docetaxel-based concurrent chemotherapy, and 43 were given weekly cisplatin-based concurrent chemotherapy. Radiotherapy was administered using a conventional technique (seven weeks, 2.0 Gy per fraction, total dose 70-74 Gy) with 6-8 Gy boosts for some patients with locally advanced disease. Results: Median follow-up time was 42.3 months (range, 8.6-50.8 months). There were no significant differences in the 3-year loco-regional failure-free survival (85.6% vs. 92.3%; p=0.264), distant failure-free survival (87.0% vs. 92.5%; p=0.171), progression-free survival (85.7% vs. 88.4%; p=0.411) or overall survival (86.5% vs. 92.5%, p=0.298) of patients treated concurrently with docetaxel or cisplatin. Severe toxicity was not common in either group. Conclusions: Weekly docetaxel-based concurrent chemoradiotherapy is potentially effective and has a tolerable toxicity; however, further investigations are required to determine if docetaxel is superior to cisplatin for advanced stage NPC.

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