한국재료학회지 (Korean Journal of Materials Research)

  • 제22권6호
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  • Pages.285-291
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  • 2012
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  • 1225-0562(pISSN)
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  • 2287-7258(eISSN)
한국재료학회 (Materials Research Society of Korea)
권호 표지
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천연 및 인공원료로부터 제조한 생체친화형 하이드록시아파타이트 세라믹스

Biocompatible Hydroxyapatite Ceramics Prepared from Natural Bones and Synthetic Materials

  • 이종국 (조선대학교 신소재공학과) ;
  • 고영화 (조선대학교 신소재공학과) ;
  • 이난희 (조선대학교 신소재공학과)
  • Lee, Jong-Kook (BK21 Education Center of Mould Technology for Advanced Materials & Parts, Department of Advanced Materials Engineering, Chosun University) ;
  • Ko, Young-Hwa (BK21 Education Center of Mould Technology for Advanced Materials & Parts, Department of Advanced Materials Engineering, Chosun University) ;
  • Lee, Nan-Hee (BK21 Education Center of Mould Technology for Advanced Materials & Parts, Department of Advanced Materials Engineering, Chosun University)
  • 투고 : 2012.05.22
  • 심사 : 2012.05.31
  • 발행 : 2012.06.27
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초록

Hydroxyapatite (HA) is well known as a biocompatible and bioactive material. HA has been practically applied as bone graft materials in a range of medical and dental fields. In this study, two types of dense hydroxyapatite ceramics were prepared from natural bones and synthetic materials. The biocompatibility of HA ceramics for supporting osteoblast cell growth and cytotoxicity using an in vitro MG-63 cell line model were respectively evaluated. Artificial hydroxyapatite shows relative density of 93% with 1-2 ${\mu}m$ after sintering, but a hydroxyapatite compact derived from bovine bone has low sintered density of 85% with a small content of MgO. Irrespective of the starting raw materials, both types of sintered hydroxyapatite displayed similar biocompatibility in the tests. FE-SEM observations showed that most MG-63 cells had a stellar shape and formed an intercellular matrix containing fibers on sintered HA. The cells were well attached and grown over the HA surface, indicating that there was no toxicity.

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