Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Mixture of Lycii Radicis Cortex and Gardeniae Fructus on the Change of HPA-Axis and Catecholamine System in the Forced Swimming Test

지골피(地骨皮)와 치자(梔子) 합제(合劑)가 강제수영부하실험에서 HPA-Axis와 Catecholamine system에 미치는 영향

  • Oh, Jeong-Jin (Formulae Pharmacology Dept. School of Oriental Medicine, Ga-Chon University) ;
  • Lee, Tae-Hee (Formulae Pharmacology Dept. School of Oriental Medicine, Ga-Chon University)
  • 오정진 (가천대학교 한의과대학 방제학교실) ;
  • 이태희 (가천대학교 한의과대학 방제학교실)
  • Received : 2012.05.30
  • Accepted : 2012.06.15
  • Published : 2012.06.30
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Abstract

Objectives : In this study the antidepressant effects of mixture of Lycii Radicis Cortex and Gardeniae Fructus on the change of HPA-Axis and Catecholamine system was investigated Methods : The forced swimming test was performed. The expression of CRF, c-Fos in the PVN, and TH in the VTA and LC were measured with immunohistochemical method. And the experimental groups were divided into the Extraction after Mix group(A) and Mix after Extraction group(B). The effects of both group were compared. Results : The duration of immobility in the FST was decreased significantly in three groups except B100(P<0.01). B100 was shown the significant increase(P<0.05). The expression of CRF in PVN was decreased significantly in all group(P<0.05~P<0.01). The expression of c-Fos in PVN was decreased in A100, A400 and was increased significantly in B100, B400(P<0.05). The expression of TH in VTA and LC were decreased significantly in all group(P<0.001). Conclusions : Effects of Extraction after Mix group(A) and Mix after Extraction group(B) on the HPA-Axis system and Catecholamine system were validated.

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References

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