Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study on Oral Administration of Egg White Combined Chalcanthite and Bamboo-Salt with Egg White Combined Chalcanthite

난담반 단독제와 난담반과 죽염 혼합제 경구 투여의 독성 연구

  • Choi, Eun-A (East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Lee, Jong-Hoon (East-West Cancer Center, College of Oriental Medicine, Daejeon University) ;
  • Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University)
  • 최은아 (대전대학교 둔산한방병원 동서암센터) ;
  • 이종훈 (대전대학교 둔산한방병원 동서암센터) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2012.01.20
  • Accepted : 2012.03.20
  • Published : 2012.04.25
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Abstract

Our former study indicated efficacy of apoptotic cell death on animal study by using Egg white combined Chalcanthite (EC). Clinically, bamboo salt is using because of safety. Hence we investigated a toxicity study for determining safety by adding bamboo salt in former materiel. We had two studies: toxicity of EC and of Bamboo salt with egg white combined Chalcanthite (BC). Both were studied in 1-week single and 5-week repeated oral dose toxicity tests on male Imprinting Control Region mice. In EC, doses used in 1 week single oral dose toxicity tests were 0, 0.05, 0.5, 5 and 50 mg/kg/day and 0, 0.01, 0.05, 0.25 and 0.5 mg/kg/day. In BC, doses used by 0, 0.08, 8.3, 83.3 and 166.6 mg/kg/day in single oral dose toxicity and 0, 4.2, 8.3, 41.7 and 83.3 mg/kg/day in repeated oral dose toxicity tests. Their blood and urine were assayed and organ morphology were examined. Mann-Whitney U test and ANOVA tests were used by analysing methods. First, significant increased left renal weight in all groups of EC and BC. Second, increased ALT score was found in EC-S2 and increased relative liver weight was found in EC-S3. In addition, increased relative weight and urine bilirubin and urobilinogen were found in EC-R2 and EC-R3. There was no significant toxic change in BC. The Mixture of EC had a possibility of hepatotoxicity in the short and long term. Processed BC appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) was established at 83.3 mg/kg/day in mice. Relatively, The BC were safer than The EC.

Keywords

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