Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Characteristic of $^{18}F$-FDG Excretion According to Use Diuretics in $^{18}F$-FDG of PET/CT

$^{18}F$-FDG PET/CT 검사에서 이뇨제 사용여부에 따른 $^{18}F$-FDG 배설 특성

  • Jang, Dong-Gun (Dept. of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer Center) ;
  • Yang, Seoung-Oh (Dept. of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer Center) ;
  • Lee, Sang-Ho (Dept. of Nuclear Medicine, Dongnam Institute of Radiological & Medical Sciences Cancer Center) ;
  • Bae, Jong-Lim (Dept. of Physics, Daegu University) ;
  • Kim, Jeong-Koo (Dept. of Radiological Science, Hanseo University)
  • 장동근 (동남권원자력의학원 핵의학과) ;
  • 양승오 (동남권원자력의학원 핵의학과) ;
  • 이상호 (동남권원자력의학원 핵의학과) ;
  • 배종림 (대구대학교 물리학과) ;
  • 김정구 (한서대학교 방사선학과)
  • Received : 2012.05.09
  • Accepted : 2012.06.18
  • Published : 2012.06.30
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Abstract

$^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG) causes a significant amount of radioactivity retention in kidneys and urinary tract and degrades image quality and diagnostic performance. Diuretics are used to perform tests and prevent the urinary tract retention of $^{18}F$-FDG. The purpose of the study is to investigate how the diuretics affect images and excretion rates of $^{18}F$-FDG. The study consists of a group using diuretics for patients with no primary tumors or transfer lesions in kidneys according to PET/CT images, a group using physiological saline and the control group injecting only $^{18}F$-FDG and SUVs are measured by configuring interested areas for each group. Also, SUVs are compared and evaluated depending on the lasix injection after basic inspection and injecting $^{18}F$-FDG for quantitative analysis. The study shows that images with decreased background radioactivity and increased urine excretion due to using diuretics. However, an opposite result that there is no change in the amount of radioactivity in urine appears. The study concludes that the diuretics may decrease background radioactivity in the images but may not affect the $^{18}F$-FDG excretion.

$^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG)는 상당한 양의 방사능이 신장과 비뇨기계에 저류 되어 영상의 질을 저하시키고 진단 성능을 저하시킨다. 이러한 $^{18}F$-FDG의 비뇨기계 저류를 막기 위해 이뇨제를 사용하여 검사를 진행하게 된다. 이때 사용되는 이뇨제가 영상에 미치는 영향과 $^{18}F$-FDG 배설률에 미치는 영향을 알아보고자 하였다. PET/CT 검사를 시행한 환자 중 신장의 원발성 종양 또는 전이 병변이 없는 환자를 대상으로 $^{18}F$-FDG와 함께 이뇨제를 주사한 그룹, 생리식염수를 주사한 그룹, $^{18}F$-FDG만을 주사 한 정상군 그룹으로 진행하였으며, 각 그룹의 관심영역을 설정하여 SUV를 측정하였다. 또한 정량적 분석을 위하여 $^{18}F$-FDG를 주사 후 이뇨제 투여 여부에 따른 SUV를 비교 평가하였다. SUV 측정에 따라 영상의 배후방사능이 감소된 영상을 얻을 수 있었으며 이뇨제 사용으로 배설된 소변의 양이 늘어났지만, 소변에 방사능량의 변화가 없는 상반된 결과가 나타났다. 따라서 이뇨제가 영상의 배후방사능을 줄일 수는 있지만 $^{18}F$-FDG 배설에는 영향을 미치지 못함을 확인 하였다.

Keywords

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