Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

Use of Platelet-Rich Fibrin in Oral and Maxillofacial Surgery

  • Jeong, Kyung-In (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University) ;
  • Oh, Ji-Su (Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University)
  • Received : 2011.12.02
  • Accepted : 2012.03.26
  • Published : 2012.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Platelet-rich fibrin (PRF) is a strong but flexible fibrin including a enrich platelet which contain growth factors and cytokines. PRF can be made very simply and requires no artificial additives unlike platelet-rich plasma. While PRF is remodeled and released in the tissue, this induces cell growth, vascularization, collagen synthesis, osteoblast differentiation and an anti-inflammatory reaction. Taking advantage of these functions, PRF can stimulate regeneration of bone and soft tissue in a diverse number of ways during the course of hemostasis, wound coverage, preservation, and reconstruction of alveolar bone. Moreover, the use of PRF to improve bone regeneration has become a recent technique in implantology. In this study, through a literature review of PRF's existing clinical applications, we classified a range of potential PRF oral and maxillofacial surgery applications including preservation of extraction sockets, guided bone graft, sinus lift, dressing and periodontal treatment. This trial gave us chance to confirm the usefulness of PRF. Recently, updated clinical studies results concerning skin and tendon wound healing have become available. These results suggest that the usage of RPF will gradually expand.

Keywords

References

  1. González-García R, Naval-Gías L, Rodríguez-Campo FJ, Muñoz- Guerra MF, Sastre-Pérez J. Vascularized free fibular flap for the reconstruction of mandibular defects: clinical experience in 42 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:191-202. https://doi.org/10.1016/j.tripleo.2007.04.002
  2. Takenobu T, Nagano M, Taniike N, Furutani M, Tanaka Y. Mandibular reconstruction using intraoral trifocal bone transport: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:630-5. https://doi.org/10.1016/j.tripleo.2006.07.004
  3. Lucarelli E, Beccheroni A, Donati D, et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 2003;24:3095-100. https://doi.org/10.1016/S0142-9612(03)00114-5
  4. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet- related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e45-50. https://doi.org/10.1016/j.tripleo.2005.07.009
  5. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:299-303. https://doi.org/10.1016/j.tripleo.2005.07.012
  6. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60. https://doi.org/10.1016/j.tripleo.2005.07.011
  7. Dohan DM, Choukroun J. PRP, cPRP, PRF, PRG, PRGF, FC How to find your way in the jungle of platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:305-6. https://doi.org/10.1016/j.tripleo.2006.10.009
  8. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;95:521-8. https://doi.org/10.1067/moe.2003.152
  9. Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T. Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. J Oral Maxillofac Surg 2005;63: 362-9. https://doi.org/10.1016/j.joms.2004.07.016
  10. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-44. https://doi.org/10.1016/j.tripleo.2005.07.008
  11. Cieslik-Bielecka A, Gazdzik TS, Bielecki TM, Cieslik T. Why the platelet-rich gel has antimicrobial activity? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:303-5. https://doi.org/10.1016/j.tripleo.2006.08.034
  12. Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101:e51-5. https://doi.org/10.1016/j.tripleo.2005.07.010
  13. Schilephake H. Bone growth factors in maxillofacial skeletal reconstruction. Int J Oral Maxillofac Surg 2002;31:469-84. https://doi.org/10.1054/ijom.2002.0244
  14. Tuan TL, Song A, Chang S, Younai S, Nimni ME. In vitro fibroplasia: matrix contraction, cell growth, and collagen production of fibroblasts cultured in fibrin gels. Exp Cell Res 1996;223:127-34. https://doi.org/10.1006/excr.1996.0065
  15. van Hinsbergh VW, Collen A, Koolwijk P. Role of fibrin matrix in angiogenesis. Ann N Y Acad Sci 2001;936:426-37.
  16. Gassling VL, Acil Y, Springer IN, Hubert N, Wiltfang J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:48-55. https://doi.org/10.1016/j.tripleo.2009.02.007
  17. Weibrich G, Kleis WK, Hafner G. Growth factor levels in the platelet-rich plasma produced by 2 different methods: curasan-type PRP kit versus PCCS PRP system. Int J Oral Maxillofac Implants 2002;17:184-90.
  18. Simon BI, Zatcoff AL, Kong JJ, O'Connell SM. Clinical and histological comparison of extraction socket healing following the use of autologous platelet-rich fibrin matrix (PRFM) to ridge preservation procedures employing demineralized freeze dried bone allograft material and membrane. Open Dent J 2009;3:92-9. https://doi.org/10.2174/1874210600903010092
  19. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:707-13. https://doi.org/10.1016/j.tripleo.2009.06.044
  20. Becker W, Urist M, Becker BE, et al. Clinical and histologic observations of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports. J Periodontol 1996;67:1025-33. https://doi.org/10.1902/jop.1996.67.10.1025
  21. Becker W, Becker BE, Caffesse R. A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128-33. https://doi.org/10.1902/jop.1994.65.12.1128
  22. Shi B, Zhou Y, Wang YN, Cheng XR. An experimental study on alveolar ridge preservation prior to dental implant placement. Zhonghua Kou Qiang Yi Xue Za Zhi 2006;41:114-5.
  23. Shi B, Zhou Y, Wang YN, Cheng XR. Alveolar ridge preservation prior to implant placement with surgical-grade calcium sulfate and platelet-rich plasma: a pilot study in a canine model. Int J Oral Maxillofac Implants 2007;22:656-65.
  24. Lee HJ, Choi BH, Jung JH, et al. Maxillary sinus floor augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:329-33. https://doi.org/10.1016/j.tripleo.2006.03.010
  25. Toffler M, Toscano N, Holtzclaw D, Del Corso M, Dohan Ehrenfest DM. Introducing Choukroun's platelet rich fibrin (prf) to the reconstructive surgery milieu. J Impl Clin Dent 2009;1:21-31. https://doi.org/10.5005/jp-journals-10004-1016
  26. Kfir E, Kfir V, Eliav E, Kaluski E. Minimally invasive guided bone regeneration. J Oral Implantol 2007;33:205-10. https://doi.org/10.1563/1548-1336(2007)33[205:MIGBR]2.0.CO;2
  27. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part I: a new grafting protocol. Implant Dent 2009;18:102-11. https://doi.org/10.1097/ID.0b013e318198cf00
  28. Simonpieri A, Del Corso M, Sammartino G, Dohan Ehrenfest DM. The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part II: implant surgery, prosthodontics, and survival. Implant Dent 2009;18:220-9. https://doi.org/10.1097/ID.0b013e31819b5e3f
  29. Simonpieri A, Choukroun J, Del Corso M, Sammartino G, Dohan Ehrenfest DM. Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent 2011;20:2-12. https://doi.org/10.1097/ID.0b013e3181faa8af
  30. Mazor Z, Horowitz RA, Del Corso M, Prasad HS, Rohrer MD, Dohan Ehrenfest DM. Sinus floor augmentation with simultaneous implant placement using Choukroun's platelet-rich fibrin as the sole grafting material: a radiologic and histologic study at 6 months. J Periodontol 2009;80:2056-64. https://doi.org/10.1902/jop.2009.090252
  31. Choi BH, Zhu SJ, Jung JH, Lee SH, Huh JY. The use of autologous fibrin glue for closing sinus membrane perforations during sinus lifts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:150-4. https://doi.org/10.1016/j.tripleo.2005.04.008
  32. Toffler M, Toscano N, Holtzclaw D. Osteotome-mediated sinus floor elevation using only platelet-rich fibrin: an early report on 110 patients. Implant Dent 2010;19:447-56. https://doi.org/10.1097/ID.0b013e3181f57288
  33. Toffler M. Osteotome-mediated sinus floor elevation: a clinical report. Int J Oral Maxillofac Implants 2004;19:266-73.
  34. Diss A, Dohan DM, Mouhyi J, Mahler P. Osteotome sinus floor elevation using Choukroun's platelet-rich fibrin as grafting material: a 1-year prospective pilot study with microthreaded implants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:572-9. https://doi.org/10.1016/j.tripleo.2007.08.021
  35. Mader JT, Stevens CM, Stevens JH, Ruble R, Lathrop JT, Calhoun JH. Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant. Clin Orthop Relat Res 2002;(403):58-72.
  36. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol 2009;80:244-52. https://doi.org/10.1902/jop.2009.080253
  37. You TM, Choi BH, Zhu SJ, et al. Treatment of experimental peri-implantitis using autogenous bone grafts and platelet- enriched fibrin glue in dogs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:34-7. https://doi.org/10.1016/j.tripleo.2006.01.005
  38. Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol 2011;82:1396-403. https://doi.org/10.1902/jop.2011.100731
  39. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg 2007;9:174-83. https://doi.org/10.1001/archfaci.9.3.174
  40. Visser LC, Arnoczky SP, Caballero O, Gardner KL. Evaluation of the use of an autologous platelet-rich fibrin membrane to enhance tendon healing in dogs. Am J Vet Res 2011;72:699-705. https://doi.org/10.2460/ajvr.72.5.699