Restorative Dentistry and Endodontics

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

상아질 접착에 대한 matrix metalloproteinase (MMP)의 영향과 이를 극복하기 위한 전략

  • Lee, Jung-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry) ;
  • Chang, Ju-Hea (Clinic for Persons with Disabilities, Seoul National University Dental Hospital) ;
  • Son, Ho-Hyun (Department of Conservative Dentistry, Seoul National University School of Dentistry)
  • 이정현 (서울대학교 치의학대학원 치과보존학교실) ;
  • 장주혜 (서울대학교 치과병원 장애인구강 진료실) ;
  • 손호현 (서울대학교 치의학대학원 치과보존학교실)
  • Received : 2011.09.06
  • Accepted : 2011.11.18
  • Published : 2012.03.01
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Abstract

The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broadspectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Keywords

References

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