Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Reduction of Local Body Fat Thickness and Stimulation of Fat Cell Lipolysis by Slim813

Slim813의 지방산 분해 촉진을 통한 슬리밍 효능 연구

  • Park, Mi-Young (Medical Beauty Research Institute, Amorepacific Co. R&D Center, Amorepacific Co. R&D Center) ;
  • Jung, Kyoung-Mi (Medical Beauty Research Institute, Amorepacific Co. R&D Center, Amorepacific Co. R&D Center) ;
  • Joo, Kyoung-Mi (Skin Research Institute, Amorepacific Co. R&D Center) ;
  • Kim, Yeon-Joon (Medical Beauty Research Institute, Amorepacific Co. R&D Center, Amorepacific Co. R&D Center) ;
  • Park, Young-Ho (Medical Beauty Research Institute, Amorepacific Co. R&D Center, Amorepacific Co. R&D Center) ;
  • Lim, Kyung-Min (Medical Beauty Research Institute, Amorepacific Co. R&D Center, Amorepacific Co. R&D Center)
  • 박미영 (아모레퍼시픽기술연구원 메디컬뷰티연구소) ;
  • 정경미 (아모레퍼시픽기술연구원 메디컬뷰티연구소) ;
  • 주경미 (아모레퍼시픽기술연구원 피부과학연구소) ;
  • 김연준 (아모레퍼시픽기술연구원 메디컬뷰티연구소) ;
  • 박영호 (아모레퍼시픽기술연구원 메디컬뷰티연구소) ;
  • 임경민 (아모레퍼시픽기술연구원 메디컬뷰티연구소)
  • Received : 2012.04.19
  • Accepted : 2012.06.10
  • Published : 2012.06.30
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Abstract

Slim813 is a 2-cyclopentene-1-one oxime derivative with potent anti-inflammatory and anti-photoaging effects. Slim813 inhibited LPS-induced TNF-${\alpha}$ production and attenuated UVB-induced MMP1 expression. Here in an attempt to find an unrevealed efficacy of Slim813, we found that Slim813 stimulates lipolysis in a dose-dependent manner by increasing intracellular cAMP level through the elevation of HSL activity in fully differentiated adipocytes. Moreover, topical application of Slim813 for two weeks in human reduced the thickness of subcutaneous fat in arm and thigh regions, implying it could be effectively used in the reduction of unwanted local fat accumulation.

Slim813은 2-사이클로펜텐-1-온 옥심 유도체로서 다양한 염증성 자극원에 대한 TNF 생성을 억제하는 항 자극 및 UV에 의한 MMP1 억제를 통한 항 노화 효능을 갖는 물질이다. 본 연구를 통하여 이와 같은 효능 외에도 완전히 분화된 지방 세포에서 cAMP (cyclic adenosine monophosphate) 생성 촉진을 통한 HSL (hormone sensitive lipase) 활성을 증대시킴으로써 지방분해를 증가시킴을 확인하였다. 또한 Slim813을 사람의 팔과 허벅지 부위에 2주간 도포하였을 때 지방의 두께 감소를 유발하는 것으로 나타나 체내 피하 지방을 분해하는 효능을 갖는 것으로 사료된다.

Keywords

References

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