Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Aldose reductase inhibitory activity of the methanol extracts from Korean folk plants

민속식물의 알도즈 환원효소 억제작용

  • Kim, Hye-Min (Department of Integrative Plant Science, Chung-Ang University) ;
  • Han, Saem (Department of Integrative Plant Science, Chung-Ang University) ;
  • Choi, Kyung (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Ku, Ja-Jung (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Park, Kwang-Woo (Department of Forest Resource Conservation, Korea National Arboretum) ;
  • Cho, Eun-Ju (Department of Food Science and Nutrition, Pusan National University) ;
  • Lee, Sang-Hyun (Department of Integrative Plant Science, Chung-Ang University)
  • 김혜민 (중앙대학교 식물시스템과학과) ;
  • 한샘 (중앙대학교 식물시스템과학과) ;
  • 최경 (국립수목원 산림보존과) ;
  • 구자정 (국립수목원 산림보존과) ;
  • 박광우 (국립수목원 산림보존과) ;
  • 조은주 (부산대학교 식품영양학과) ;
  • 이상현 (중앙대학교 식물시스템과학과)
  • Received : 2012.03.27
  • Accepted : 2012.06.18
  • Published : 2012.06.30
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Abstract

To search for the aldose reductase (AR) inhibitors from Korean folk plants, the inhibition of rat lens AR in vitro using the methanol (MeOH) extracts from Korean folk plants was investigated. Among fifty four Korean folk plants tested, the MeOH extract of Cedrela sinensis showed highest inhibition of AR ($IC_{50}$ value, 2.52 ${\mu}g/ml$). The plant C. sinensis has a possibility of new natural resources for the development of AR inhibitor for the prevention of diabetic complications.

Keywords

References

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