Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Direct Palladium-Catalyzed C-4 Arylation of Tri-substituted Furans with Aryl Chlorides: An Efficient Access to Heteroaromatics

  • Yang, Hai (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering) ;
  • Zheng, Zhishuo (Department of Physics, Guangdong University of Education) ;
  • Zeng, Jian (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering) ;
  • Liu, Huajie (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering) ;
  • Yi, Bing (The Hunan Provincial Education Department Key Laboratory of Ecological Textile Materials & Novel Dying and Finishing Technology, College of Chemistry and Chemical Engineering, Hunan Institute of Engineering)
  • Received : 2012.03.26
  • Accepted : 2012.05.10
  • Published : 2012.08.20
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Abstract

A series of functionalized furans were synthesized by way of a palladium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of $BuAd_2P$ and t-BuOK in DMF at $120^{\circ}C$ after 15 h.

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References

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