Effect of Placental Extract on Immobilization of Shoulder Joint in a Complex Regional Pain Syndrome Patient

복합국소통증증후군 환자의 견관절 운동제한에 미치는 자하거 가수분해물 약침요법의 효과

  • Received : 2012.06.29
  • Accepted : 2012.08.01
  • Published : 2012.08.20

Abstract

Complex regional pain syndrome type 1(CRPS 1) is a neuropathic pain disorder that accompanies severe pain and motor deficit as well as changes in the skin in the extremities. The pathophysiology of CRPS 1 is still not exactly elucidated. However, the general consensus of involvement of inflammatory mediators in the development of CRPS 1 is amply made. On the basis that placental extract successfully inhibited the production of inflammatory cytokines and mediators in several experimental models, we have tried a long-term weekly injection of placental extract into acupuncture points to a CRPS 1 patient suffering pain and immobilization of shoulder joint. The results say that placental extract effectively resolved pain, restored skin color and improved immobilization of shoulder joint in the CRPS 1 patient.

Keywords

References

  1. Yeom MJ, Lee HC, Kim GH, Shim I, Lee HJ, Hahm DH. Therapeutic effect of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol Pharm Bull. 2003 ; 26(10) : 1472-7. https://doi.org/10.1248/bpb.26.1472
  2. Liu KX, Kato Y, Kaku T, Sugiyama Y. Human placental extract stimulates liver regeneration in rats. Biol Pharm Bull. 1998 ; 21(1) : 44-9. https://doi.org/10.1248/bpb.21.44
  3. Kim JK, Kim TH, Park SW, Kim HY, Kim SH, Lee SY, Lee SM. Protective effect of human placenta extract on cartilage degradation in experimental osteoarthritis. Biol Pharm Bull. 2010 ; 33(6) : 1004-10. https://doi.org/10.1248/bpb.33.1004
  4. Lee KH, Kim TH, Lee WC, Kim SH, Lee SY, Lee SM. Anti-inflammatory and analgesic effects of human placenta extract. Nat Prod Res. 2011 ; 25(11) : 1090-100. https://doi.org/10.1080/14786419.2010.489050
  5. Wasner G, Schattschneider J, Binder A, Baron R. Complex regional pain syndrome-diagnostic, mechanism, CNS involvement and therapy. Spinal Cord. 2003 ; 41(2) : 61-75. https://doi.org/10.1038/sj.sc.3101404
  6. Maleki J, LeBel AA, Bennett GJ, Schwartzman RJ. Patterns of spread in complex regional pain syndrome, type I (reflex sympathetic dystrophy). Pain. 2000 ; 88(3) : 259-66. https://doi.org/10.1016/S0304-3959(00)00332-8
  7. Pertoldi S, Di Benedetto P. Shoulder-hand syndrome after stroke. A complex regional pain syndrome. Eura Medicophys. 2005 ; 41(4) : 283-92.
  8. Birklein F, Schmelz M, Schifter S, Weber M. The important role of neuropeptides in complex regional pain syndrome. Neurology. 2001 ; 57 (12) : 2179-84.
  9. Huygen FJ, De Bruijin AG, De Bruin MT, Groeneweg JG, Klein J, Zijlstra FJ. Evidence for local inflammation in complex regional pain syndrome type I. Mediators Inflamm. 2002 ; 11 (1) : 47-51. https://doi.org/10.1080/09629350210307
  10. Hwang JH, Cho HS, Lee HJ, Lee DG, Jeong WJ, Jung CY, Kim KH. Effect of inhibition macrophage migration inhibitory factor activation by Hominis placenta herbal acupuncture on rheumatic arthritis. J Kor Acupunc Moxibus. 2008 ; 25(3) : 41-51.
  11. Lin JJ, Wu YT, Wang SF, Chen SY. Trapezius muscle imbalance in individuals suffering from frozen shoulder syndrome. Clin Rheumatol. 2005 ; 24(6) : 569-75. https://doi.org/10.1007/s10067-005-1105-x
  12. Halder AM, Zhao KD, Odriscoll SW, Morrey BF, An KN. Dynamic contributions to superior shoulder stability. J Orthop Res. 2001 ; 19(2) : 206-12. https://doi.org/10.1016/S0736-0266(00)00028-0
  13. Jankovic D, van Zundert A. The frozen shoulder syndrome. Description of a new technique and five case reports using the subscapular nerve block and subscapularis trigger point infiltration. Acta Anaesthesiol Belg. 2006 ; 57(2) : 137-43.
  14. Nelson KH, Briner W Jr, Cummins J. Corticosteroid injection therapy for overuse injuries. Am Fam Physician. 1995 ; 52(6) : 1811-6.