DOI QR코드

DOI QR Code

Improvement of Skin Moisture Capacity through Dietary Beauty Supplement Containing Ceramides Derived from Rice

쌀 유래 세라마이드를 함유한 미용보조제의 피부미용개선 효과

  • Received : 2012.03.26
  • Accepted : 2012.05.14
  • Published : 2012.08.31

Abstract

A placebo-controlled double-blind ingestion study of a beauty supplement containing rice-derived ceramide was performed. Thirty three subjects who always tended to have rough skin due to dryness participated in the study. Dermatological diagnosis by physicians showed that the supplement significantly improved dryness and itching of the skin. On measurement of water content in the skin, the supplement was shown to significantly increase water content in the skin. On microscopic three-dimensional analysis of the epidermis, the supplement was shown to improve smoothness, exfoliation, and short-term ingestion of the supplement containing rice derived ceramide, which is very effective as skin beautifying food.

쌀 유래 세라마이드를 함유한 미용보조제의 섭취에 관한 위약 대조, 이중 맹검 연구가 건조함으로 인해 항상 피부가 거친 경향이 있었던 33명의 피험자들에게 실시되어 다음과 같은 결과가 얻어졌다. 섭취 6주 후 피부과적 진단에 따르면 건조함, 홍조, 화장 유지력, 가려움 등의 관찰항목에서 플라시보 군 및 세라마이드군 모두에서 개선효과가 있었으나 플라시보 군 에서는 개선율이 43.8%인 반면, 세라마이드 군의 개선율은 64.7%로 높았다. 수분량, 유분량, pH 측정결과를 보면, 플라시보 군과 세라마이드 군 모두에서 유분량 및 pH 관련하여 유의한 변화는 없었다. 그러나 수분량에서는 플라시보 군에서 유의한 변화가 없었던 반면, 세라마이드 군에서는 6주 후 유의한 수분량 증가가 있었다. 3차원 현미경 경피분석시스템에 의한 분석결과에 따르면, 세라마이드 군에서는 Kurtosis, 유연성지수(SEsm), 거�s지수(SEr), 각질 및 인설 지수(SEsc), 주름지수(SEw)가 유의하게 개선되었으나 플라시보 군에서는 어떠한 유의한 변화도 관찰되지 않았다. 이는 이중맹검법으로 실시된 이번 연구에서 피부과적 진단이 명백한 플라시보 효과를 보인 점과 대비된다. 이로써 의사들에 의한 관찰과 더불어 과학적이고 객관적인 측정에 의해 세라마이드는 피부건조함과 거�s을 개선하는 데 효과가 있음이 입증되었고 경구섭취로 그 효과가 나타났다. 상기 결과는 쌀 유래 세라마이드 보조제의 장기간에 걸친 섭취가 보습, 피부의 유연성 유지에 효과적이고 따라서 효과적인 피부미용식품임을 보여준다.

Keywords

References

  1. Loden M. Role of topical emollients and moisturizers in the treatment dry skin barrier disorder. Am J. Clin. Dermatol. 4: 771-788 (2003) https://doi.org/10.2165/00128071-200304110-00005
  2. Sator PG, Schmidt JB, Honigsmann H. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J. Am. Acad. Dermatol. 48: 352-358 (2003) https://doi.org/10.1067/mjd.2003.105
  3. Law S, Wetrz PW, Swartzendruber DC, Squier CA. Regional variation in content, composition and organization of porcine epithelial barrier lipids revealed by thin-layer chromatography and transmission electron microscopy. Arch. Oral. Biol. 40: 1085-1091 (1995) https://doi.org/10.1016/0003-9969(95)00091-7
  4. Dowing DT. Lipid and protein structures in the permeability barrier of mammalian epidermis. J. Lipid Res. 33: 310-313 (1992)
  5. Schurer NY, Elias PM. Biochemistry and function of stratum corneum lipids. Adv. Lipid Res. 24: 27-56 (1991) https://doi.org/10.1016/B978-0-12-024924-4.50006-7
  6. Kang BW, Mitsutake S, Okada T. Isolation and characterization of major glycosphingolipid from rice bran extract. J. Korean Soc. Apple. Biol. Chem. 50: 72-76 (2007)
  7. Yu CS, Kim SH, Kim JD. A study of the safety & effect of products containing ceramide, glucan for atopic dermatitis. J. Soc. Cosmet. Scientists Korea 30: 533-541 (2004)
  8. Lodn M. The skin barrier and use of moisturizers in atopic dermatitis. Clin. Dermatol. 21: 145-157 (2003) https://doi.org/10.1016/S0738-081X(02)00373-5
  9. Yahagi K, Iwai H. Application of surfactants in personal care products. J. Jpn Oil. Chem. Soc. 45: 1133-1143 (1996) https://doi.org/10.5650/jos1996.45.1133
  10. Asai S, Miyachi H. Evaluation of skin-moisturizing effects of oral or percutaneous use of plant ceramides. Rinsho. Byori. 55: 209-215 (2007)
  11. Jiang SJ, Chu AW, Lu ZF, Pan MH, Che DF, Zhou XJ. Ultraviolet B-induced alterations of the skin barrier and epidermal calcium gradient. Exp. Dermatol. 16: 985-992 (2007) https://doi.org/10.1111/j.1600-0625.2007.00619.x
  12. Ishida-Yamamoto A, Iizuka H. Structural organization of cornified cell envelopes and alterations in inherited skin disorders. Exp. Dermatol. 7: 1-10 (1998) https://doi.org/10.1111/j.1600-0625.1998.tb00295.x
  13. Haratake A, Uchida Y, Schmuch M. UVB-induced alterations in permeability barrier function: Roles for epidermal hyperproliferation and thymocyte-mediated response. J. Invest. Dermatol. 108: 769-775 (1998)
  14. Park CS. Skin barrier and beauty foods. Food Sci. Indus. 40: 19-26 (2008)
  15. Jiang S, Oh SY, Lee SH. Water impermeable occusion effects to intercorneocyte lipid layers in hairless mice. Ann. Dermatol. 9: 116-125 (1997) https://doi.org/10.5021/ad.1997.9.2.116
  16. Werner Y, Myers MC, Taylor DA. Electron probe analysis of human skin: determination of water concentration profile. J. Invest. Dermatol. 90: 218-224 (1988) https://doi.org/10.1111/1523-1747.ep12462252
  17. Imokawa G, Abe A, Jin K, Higaki Y. Decresed level of ceramides in stratum corneum of atopic dermatitis: An etioogic factor on atopic dry skin. J. Invest. Dermatol. 96: 523-526 (1991) https://doi.org/10.1111/1523-1747.ep12470233
  18. Tagami H, Kanamaru Y, Inoue K. Water sorption adsorption test of the skin in vivo for functional assessment of the straum corneum. J. Invest. Dermatol. 78: 425-428 (1982) https://doi.org/10.1111/1523-1747.ep12507756
  19. Holleran WH, Tagaki Y, Imokawa G, Jackson S, Lee JM, Elias PM. Beta-glucocerabrosidase activity inmurine epidermis: Characterization and Iocalization in relation to differentiation. J. Lipid Res. 33: 1201-1209 (1992)
  20. Holleran WH, Tagaki Y, Menon GK. Processing of epidermal glucosylceramides is required for optimal mammalidan cutaneous permeablity barrier function. J. Clin. Invest. 91: 1656-1664 (1993) https://doi.org/10.1172/JCI116374
  21. Mauro T, Grayson S, Gao WN. Barrier recovery is impeded at neutral pH, independence of ionic effects; Implications for extracellular lipid processing. Arch. Dermatol. Res. 290: 215-222 (1998) https://doi.org/10.1007/s004030050293
  22. Grayson S, Behne M, Man MQ. Lamellar body and stratum corneum extracelluar acidification implications for the permeability barrier. Clin. Res. 41: 401A (1993)
  23. Blichmann CW, Serup J. Hydration studies on scaly hand eczema. Contact Dermatitis 16: 115-119 (1987) https://doi.org/10.1111/j.1600-0536.1987.tb01400.x
  24. Miyanishi K, Shiono N, Shirai H, Dombo M, Kimata H. Reduction of transepidermal water loss by oral intake of glucosylceramides in patents with atopic eczema. Allergy 60: 1454-1455 (2005)