DOI QR코드

DOI QR Code

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

  • 발행 : 2012.06.30

초록

The prevalence of human papillomavirus genotypes differs in various target organs. HPV16 is the most prevalent genotype in the cervix while genotypes 6 and 11 are highly prevalent in skin and aero-digestive tract infections. In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing. Five HPV11 whole genomes were characterized, consisting of two cervical specimens, two laryngeal specimens and one lung specimen. The results showed high homology of HPV11 in these organs. Phylogenetic analysis showed that all HPV11 derived from various organs belonged to the same lineage. Molecular characterization and functional studies can further our understanding of virulence, expression or transmission. Additional studies on functional protein expression at different organ sites will also contribute to our knowledge of HPV infection in various organs.

키워드

참고문헌

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피인용 문헌

  1. Genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11 vol.202, pp.5, 2013, https://doi.org/10.1007/s00430-013-0297-y
  2. Human Papillomavirus Type 6 and 11 Genetic Variants Found in 71 Oral and Anogenital Epithelial Samples from Australia vol.8, pp.5, 2013, https://doi.org/10.1371/journal.pone.0063892
  3. Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences vol.90, pp.11, 2016, https://doi.org/10.1128/JVI.03149-15