Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Prediction of Time to Recurrence and Influencing Factors for Gastric Cancer in Iran

  • Roshanaei, Ghodratollah (Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences) ;
  • Ghannad, Masoud Sabouri (Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences) ;
  • Safari, Maliheh (Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences) ;
  • Sadighi, Sanambar (Department of Medical Oncology, Cancer Research Center, Cancer Institute, Imam Khomeini Hospital)
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background: The patterns of gastric cancer recurrence vary across societies. We designed the current study in an attempt to evaluate and reveal the outbreak of the recurrence patterns of gastric cancer and also prediction of time to recurrence and its effected factors in Iran. Materials and Methods: This research was performed from March 2003 to February 2007. Demographic characteristics, clinical and pathological diagnosis and classification including pathologic stage, tumor grade, tumor site and tumor size in of patients with GC recurrent were collected from patients' data files. To evaluate of factors affected on the relapse of the GC patients, gender, age at diagnosis, treatment type and Hgb were included in the research. Data were analyzed using Kaplan-Meier and logistic regression models. Results: After treatment, 82 patients suffered recurrence, 42, 33 and 17 by the ends of first, second and third years. The mean ( SD) and median ( IQR) time to recurrence in patients with GC were 25.5 (20.6-30.1) and 21.5 (15.6-27.1) months, respectively. The results of multivariate analysis logistic regression showed that only pathologic stage, tumor grade and tumor site significantly affected the recurrence. Conclusions: We found that pathologic stage, tumor grade and tumor site significantly affect on the recurrence of GC which has a high positive prognostic value and might be functional for better follow-up and selecting the patients at risk. We also showed time to recurrence to be an important factor for follow-up of patients.

Keywords

References

  1. An JY, Youn HG, Ha TK (2008). Clinical significance of tumor location in remnant gastric cancers developed after partial gastrectomy for primary gastric cancer. J Gastrointest Surg, 12, 689-94. https://doi.org/10.1007/s11605-007-0437-z
  2. Bilici A, Salman T, Oven Ustaalioglu BB (2012). The prognostic value of detecting symptomatic or asymptomatic recurrence in patients with gastric cancer after a curative gastrectomy. J Surg Res, (in press).
  3. Chan AO, Chu KM, Lam SK (2005). Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin. Cancer, 104, 740-6. https://doi.org/10.1002/cncr.21260
  4. Chopra A (2008). 99mTc-Labeled anti-carcinoembryonic antigen monoclonal antibody CL-58. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2012.
  5. Ikeda Y, Saku M, Kishihara F (2005). Effective follow-up for recurrence or a second primary cancer in patients with early gastric cancer. Br J Surg, 92, 235-9. https://doi.org/10.1002/bjs.4758
  6. Kim JH, Jang YJ, Park SS (2010). Benefit of post-operative surveillance for recurrence after curative resection for gastric cancer. J Gastrointest Surg, 14, 969-76. https://doi.org/10.1007/s11605-010-1200-4
  7. Koo DH, Ryoo BY, Kim HJ (2011). A prognostic model in patients who receive chemotherapy for metastatic or recurrent gastric cancer: validation and comparison with previous models. Cancer Chemother Pharmacol, 68, 913-21. https://doi.org/10.1007/s00280-011-1561-8
  8. Kosuga T, Ichikawa D, Komatsu S (2011). Prognostic impact of cancer-related symptoms in recurrent gastric cancer patients. Hepatogastroenterology, 58, 213-7.
  9. Lai JF, Kim S, Kim K (2009). Prediction of recurrence of early gastric cancer after curative.resection. Ann Surg Oncol, ?, 1896-902.
  10. Marrelli D, De Stefano A, De Manzoni G (2005). Prediction of recurrence after radical surgery for gastric cancer, a scoring system obtained from a prospective multicenter study. Ann Surg, 241, 247-55. https://doi.org/10.1097/01.sla.0000152019.14741.97
  11. Nunobe S, Hiki N, Ohyama S (2011). Outcome of surgical treatment for patients with locoregional recurrence of gastric cancer. Langenbecks Arch Surg, 396, 161-6. https://doi.org/10.1007/s00423-010-0730-2
  12. Park JC, Lee SK, Seo JH (2010). Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience. Surg Endosc, 24, 2842-9. https://doi.org/10.1007/s00464-010-1060-8
  13. Parkin DM, Bray F, Ferlay J (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  14. Roshanaei G, Kazemnejad A, Sadighi S (2011). Assessment of risk factors affecting recurrence of patients with gastric cancer in the presence of informative censoring in Iran. Asian Pac J Cancer Prev, 12, 2443-6.
  15. Roviello F, Marrelli D, De Manzoni G (2003). Prospective study of peritoneal recurrence after curative surgery for gastric cancer. Br J Surg, 90, 1113-9. https://doi.org/10.1002/bjs.4164
  16. Wu LL, Liang H, Wang XN (2010). Risk factors of early recurrence in patients with gastric cancer after curative resection. Zhonghua Wai Ke Za Zhi, 48, 1542-5.