Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Anti-allergic Effect sof Bee Venom on IgE-mediated Type I hypersensitivity Response in vivo

봉독이 IgE가 매개하는 제1형 과민반응 동물모델에 미치는 항알레르기 효과

  • Kim, Kyung-Jong (Department of Biochemistry, College of Natural Sciences, Kangwon National University) ;
  • Jeoung, Doo-Il (Department of Biochemistry, College of Natural Sciences, Kangwon National University) ;
  • Han, Chung-Sub (R&D Center, Dong Sung Bio Pharm Co. Ltd.) ;
  • Chun, Sung-Nam (R&D Center, Dong Sung Bio Pharm Co. Ltd.) ;
  • Kwon, Chung-Moo (R&D Center, Dong Sung Bio Pharm Co. Ltd.)
  • 김경종 (강원대학교 자연과학대학 생화학과) ;
  • 정두일 (강원대학교 자연과학대학 생화학과) ;
  • 한충섭 (동성제약(주) 중앙연구소) ;
  • 천성남 (동성제약(주) 중앙연구소) ;
  • 권중무 (동성제약(주) 중앙연구소)
  • Received : 2012.05.11
  • Accepted : 2012.09.07
  • Published : 2012.09.30
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Abstract

Bee venom (BV), well known as a traditional Oriental medicine, has been widely used in the treatment of some immune-related diseases. However, the anti-allergic effect of BV have not been reported. In this study, we investigated the antiallergic effect of BV on triphasic cutaneous reaction (TpCR) and passive cutaneous anaphylaxis (PCA). Our results indicated that BV suppress ear swelling and vascular permeability on IgE mediated type I hypersensitivity response. Increase in ear thickness was significantly inhibited by BV in this model. BV also blocked the infiltration of immune cells into the ear. Moreover, BV suppressed expression of HDAC3, Tryptase, MCP-1 in ear tissue. These results demonstrated that BV has a suppressive effect on allergic reaction.

Keywords

References

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