Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Extract and Isorhamnetin Glycoside from Brassica juncea on Hepatic Alcohol-Metabolizing Enzyme System in Rats

  • Hur, Jong-Moon (Research Institute of Korean Oriental Medicine, Sunchon National University) ;
  • Park, Sang-Hyun (Research Institute of Korean Oriental Medicine, Sunchon National University) ;
  • Choi, Jong-Won (Department of Pharmacy, Kyungsung University) ;
  • Park, Jong-Cheol (Research Institute of Korean Oriental Medicine, Sunchon National University)
  • Received : 2012.07.04
  • Accepted : 2012.09.04
  • Published : 2012.09.30
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Abstract

The effects of methanol extract of the leaves of Brassica juncea and its major component, isorhamnetin 3-O-${\beta}$-D-glucopyranoside on hepatic alcohol metabolizing enzymes were investigated. The methanol extract and isorhamnetin 3-O-${\beta}$-D-glucopyranoside supplementations increased the activities of microsomal ethanol oxidizing system and aldehyde dehydrogenase in a dose-dependent manner, and had mild effects on the activities of alcohol dehydrogenase and catalase. Isorhamnetin 3-O-${\beta}$-D-glucopyranoside alleviated the adverse effect of ethanol ingestion by enhancing the activities of alcohol oxidizing emzymes, microsomal ethanol oxidizing system and aldehyde dehydrogenase.

Keywords

References

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