Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지
DOI QR코드

DOI QR Code

Alcohol Consumption and Mortality in the Korean Multi-center Cancer Cohort Study

  • Jung, En-Joo (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Shin, Ae-Sun (Cancer Epidemiology Branch, National Cancer Center) ;
  • Park, Sue-K. (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Ma, Seung-Hyun (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Cho, In-Seong (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Bo-Young (Cancer Epidemiology Branch, National Cancer Center) ;
  • Lee, Eun-Ha (Cancer Epidemiology Branch, National Cancer Center) ;
  • Chang, Soung-Hoon (Department of Preventive Medicine, Konkuk University School of Medicine) ;
  • Shin, Hai-Rim (Cancer Epidemiology Branch, National Cancer Center) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • Received : 2012.03.12
  • Accepted : 2012.06.25
  • Published : 2012.09.29
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To examine the association between alcohol consumption habit, types of beverages, alcohol consumption quantity, and overall and cancer-specific mortality among Korean adults. Methods: The alcohol consumption information of a total of 16 320 participants who were 20 years or older from the Korean Multicenter Cancer Cohort were analyzed to examine the association between alcohol consumption habit and mortality (median follow-up of 9.3 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) of alcohol consumption to mortality adjusting for age, sex, geographic areas, education, smoking status, and body mass index. Results: Alcohol drinkers showed an increased risk for total mortality compared with never drinkers (HR, 1.72; 95% confidence interval [CI], 1.38 to 2.14 for past drinkers; HR, 1.21; 95% CI, 1.06 to 1.39 for current drinkers), while past drinkers only were associated with higher risk for cancer deaths (HR, 1.84; 95% CI, 1.34 to 2.53). The quantity of alcohol consumed per week showed a J-shaped association with risk of mortality. Relative to light drinkers (0.01 to 90 g/wk), never drinkers and heavy drinkers (>504 g/wk) had an increased risk for all-cause and cancer deaths: (HR, 1.18; 95% CI, 0.96 to 1.45) and (HR, 1.39; 95% CI, 1.05 to 1.83) for all-cause mortality; and (HR, 1.55; 95% CI, 1.15 to 2.11) and (HR, 2.07; 95% CI, 1.39 to 3.09) for all cancer mortality, respectively. Heavy drinkers (>504 g/wk) showed an elevated risk for death from stomach and liver cancers. Conclusions: The present study supports the existence of a J-shaped association between alcohol consumption quantity and the risk of all-cause and cancer deaths. Heavy drinkers had an increased risk of death from cancer overall and liver and stomach cancer.

Keywords

References

  1. Sull JW, Yi SW, Nam CM, Choi K, Ohrr H. Binge drinking and hypertension on cardiovascular disease mortality in Korean men and women: a Kangwha cohort study. Stroke 2010;41(10): 2157-2162.
  2. Ferreira MP, Weems MK. Alcohol consumption by aging adults in the United States: health benefits and detriments. J Am Diet Assoc 2008;108(10):1668-1676.
  3. Karlamangla AS, Sarkisian CA, Kado DM, Dedes H, Liao DH, Kim S, et al. Light to moderate alcohol consumption and disability: variable benefits by health status. Am J Epidemiol 2009;169(1): 96-104.
  4. Mukamal KJ, Rimm EB. Alcohol consumption: risks and benefits. Curr Atheroscler Rep 2008;10(6):536-543.
  5. Bongaerts BW, van den Brandt PA, Goldbohm RA, de Goeij AF, Weijenberg MP. Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. Int J Cancer 2008;123(10):2411-2417.
  6. Fan Y, Yuan JM, Wang R, Gao YT, Yu MC. Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr Cancer 2008;60(3):354-363.
  7. La Vecchia C. Alcohol and liver cancer. Eur J Cancer Prev 2007; 16(6):495-497.
  8. Fan AZ, Russell M, Dorn J, Freudenheim JL, Nochajski T, Hovey K, et al. Lifetime alcohol drinking pattern is related to the prevalence of metabolic syndrome. The Western New York Health Study (WNYHS). Eur J Epidemiol 2006;21(2):129-138.
  9. Sung KC, Kim SH, Reaven GM. Relationship among alcohol, body weight, and cardiovascular risk factors in 27,030 Korean men. Diabetes Care 2007;30(10):2690-2694.
  10. Kim S, Popkin BM, Siega-Riz AM, Haines PS, Arab L. A crossnational comparison of lifestyle between China and the United States, using a comprehensive cross-national measurement tool of the healthfulness of lifestyles: the Lifestyle Index. Prev Med 2004;38(2):160-171.
  11. Zheng W, Chow WH, Yang G, Jin F, Rothman N, Blair A, et al. The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol 2005;162(11): 1123-1131.
  12. Min S, Noh S, Shin J, Ahn JS, Kim TH. Alcohol dependence, mortality, and chronic health conditions in a rural population in Korea. J Korean Med Sci 2008;23(1):1-9.
  13. Yoo KY, Shin HR, Chang SH, Lee KS, Park SK, Kang D, et al. Korean Multi-center Cancer Cohort Study including a Biological Materials Bank (KMCC-I). Asian Pac J Cancer Prev 2002;3(1):85-92.
  14. Greenfield TK, Kerr WC, Bond J, Ye Y, Stockwell T. Graduated Fre quencies alcohol measures for monitoring consumption patterns: results from an Australian national survey and a US diary validity study. Contemp Drug Probl 2009;36(3-4):75056015.
  15. Fuchs CS, Stampfer MJ, Colditz GA, Giovannucci EL, Manson JE, Kawachi I, et al. Alcohol consumption and mortality among women. N Engl J Med 1995;332(19):1245-1250.
  16. Thun MJ, Peto R, Lopez AD, Monaco JH, Henley SJ, Heath CW Jr, et al. Alcohol consumption and mortality among middleaged and elderly U.S. adults. N Engl J Med 1997;337(24):1705-1714.
  17. Zakhari S. Alcohol and the cardiovascular system: molecular mechanisms for beneficial and harmful action. Alcohol Health Res World 1997;21(1):21-29.
  18. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 1999;319(7224):1523-1528.
  19. Kono S, Ikeda M, Tokudome S, Nishizumi M, Kuratsune M. Cigarette smoking, alcohol and cancer mortality: a cohort study of male Japanese physicians. Jpn J Cancer Res 1987;78(12): 1323-1328.
  20. International Agency for Research on Cancer. IARC srengthens its findings on several carcinogenic personal habits and household exposures; 2009 [cited 2012 Sep 17]. Available from: http: //www.iarc.fr/en/media-centre/pr/2009/pdfs/pr196_E.pdf.
  21. Chao C, Li Q, Zhang F, White E. Alcohol consumption and risk of lung cancer in the VITamins And Lifestyle Study. Nutr Cancer 2011;63(6):880-888.
  22. Bandera EV, Freudenheim JL, Vena JE. Alcohol consumption and lung cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev 2001;10(8):813-821.
  23. Shimazu T, Sasazuki S, Wakai K, Tamakoshi A, Tsuji I, Sugawara Y, et al. Alcohol drinking and primary liver cancer: a pooled analysis of four Japanese cohort studies. Int J Cancer 2012; 130(11):2645-2653.
  24. Kim MK, Ko MJ, Han JT. Alcohol consumption and mortality from all-cause and cancers among 1.34 million Koreans: the results from the Korea national health insurance corporation's health examinee cohort in 2000. Cancer Causes Control 2010; 21(12):2295-2302.
  25. Kim J, Park S, Nam BH. Gastric cancer and salt preference: a population-based cohort study in Korea. Am J Clin Nutr 2010; 91(5):1289-1293.
  26. Baglietto L, English DR, Hopper JL, Powles J, Giles GG. Average volume of alcohol consumed, type of beverage, drinking pattern and the risk of death from all causes. Alcohol Alcohol 2006; 41(6):664-671.
  27. Gronbaek M, Becker U, Johansen D, Gottschau A, Schnohr P, Hein HO, et al. Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med 2000;133(6):411-419.
  28. Bagnardi V, Blangiardo M, La Vecchia C, Corrao G. A meta-analysis of alcohol drinking and cancer risk. Br J Cancer 2001;85(11): 1700-1705.

Cited by

  1. Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies vol.25, pp.8, 2012, https://doi.org/10.1093/annonc/mdu020
  2. Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea vol.14, pp.None, 2012, https://doi.org/10.1186/1471-2407-14-420
  3. The relationship between mild alcohol consumption and mortality in Koreans: a systematic review and meta-analysis vol.15, pp.1, 2012, https://doi.org/10.1186/s12889-015-2263-7
  4. Alcohol consumption and gastric cancer risk: a meta-analysis of prospective cohort studies vol.8, pp.47, 2012, https://doi.org/10.18632/oncotarget.19177
  5. Association between alcohol consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies vol.8, pp.48, 2017, https://doi.org/10.18632/oncotarget.20880
  6. Alcohol consumption and gastric cancer risk in Korea: a case-control study vol.13, pp.5, 2012, https://doi.org/10.4162/nrp.2019.13.5.425