The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Observation of Inflammatory Marker Levels in Sprague-Dawley Rats with Youngyopaedoc-san-related Anti-atherogenic Effect

연교패독산(連翹敗毒散) 복용 후 항동맥경화 효과가 나타난 백서에서 염증 지표 관찰

  • Yoon, Da-Rae (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital) ;
  • Hong, Sung-In (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital) ;
  • Noh, Hyun-In (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital) ;
  • Yi, Seo-Ra (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital) ;
  • Lee, In-Hee (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital) ;
  • Lew, Jae-Hwan (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyunhee University / Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital)
  • 윤다래 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실) ;
  • 홍성인 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실) ;
  • 노현인 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실) ;
  • 이서라 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실) ;
  • 이인희 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실) ;
  • 류재환 (경희대학교 한의과대학 내과학교실, 경희대학교 한방병원 동서협진실)
  • Received : 2013.05.30
  • Accepted : 2013.07.17
  • Published : 2013.09.30
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Abstract

Objectives: Sprague-Dawley rats were fed with high fat diet, and atherogenic changes were seen in the aorta. However, when Sprague-Dawley rats were fed with a high fat diet and administered Youngyopaedoc-san together, these atherogenic changes were rarely seen. This study was aimed to find the inflammatory marker level changes in Sprague-Dawley rats with Youngyopaedoc-san-related anti-atherogenic effect. Methods: The extract from Youngyopaedoc-san was made by the pharmacy department of Kyung-hee Oriental Medical Hospital. The animals were divided into five groups: normal diet, high fat diet, high fat diet with Youngyopaedoc-san, high fat diet with Vytorin, and high fat diet with Youngyopaedoc-san and Vytorin. A light microscopic image of a cross section taken from the aorta of the Sprague-Dawley rat was analyzed. We compared inflammatory marker levels among the five groups. Results: The complex of Youngyopaedoc-san and Vytorin has more anti-atherogenic effects in the aorta of Sprague-Dawley rats fed with high fat diet than Vytorin alone. Youngyopaedoc-san has inhibitory effect on the increase of IFN-${\gamma}$ and IL-2 levels. The difference on eosinophil levels of each group was statistically significant, but the eosinophil level of each group was within normal limits, so the difference on eosinophil levels was not clinically significant. Conclusions: Youngyopaedoc-san-related anti-atherogenic effect could be a result of inhibitory mechanism on IFN-${\gamma}$ and IL-2.

Keywords

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