한국방사선학회논문지 (Journal of the Korean Society of Radiology)

  • 제7권6호
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  • Pages.433-439
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  • 2013
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  • 1976-0620(pISSN)
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  • 2384-0633(eISSN)
한국방사선학회 (The Korean Society of Radiology)
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집속 초음파 뇌 질환 치료를 위한 두부 유사 팬텀의 개발

Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound

  • 민정화 (인제대학교 의료영상과학과) ;
  • 김주영 (인제대학교 의용공학과) ;
  • 노시철 (한국국제대학교 방사선학과) ;
  • 최흥호 (인제대학교 의료영상과학과)
  • Min, Jeonghwa (Dept. of Medical Imaging Science, Inje University) ;
  • Kim, Juyoung (Dept. of Biomedical Engineering, Inje University) ;
  • Noh, Sicheol (Dept. of Radiological Science, International University of Korea) ;
  • Choi, Heungho (Dept. of Medical Imaging Science, Inje University)
  • 투고 : 2013.11.12
  • 심사 : 2013.12.25
  • 발행 : 2013.12.25
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초록

본 연구에서는 집속형 초음파를 이용하는 뇌 질환 치료의 연구를 위한 인체 두부 유사 팬텀을 개발하였다. 문헌 연구를 통하여 피부 조직, 두개골, 뇌 조직의 음향학적 및 물리적 특성을 조사하였으며 근사한 값을 가지는 적합한 각 조직 대체 물질을 제시하였다. 피부 조직의 경우 글리세롤 기반 연부 조직 유사 팬텀의 성분비를 조정하여 실제 조직과 유사한 음향학적 특성을 가지도록 하였으며 고분자 합성수지의 음향학적 특성을 측정하여 두개골 유사 물질로써의 적합성을 평가하였다. 뇌 조직은 투명한 egg white 팬텀을 이용하여 집속형 초음파의 가열 특성을 확인할 수 있도록 하였다. 또한 뇌 질환 치료 프로토콜 개발을 위한 시험 조사가 가능하도록 대체 물질들을 결합한 두부 유사 팬텀을 제작하였고 제작된 팬텀의 유효성 및 활용성 평가를 위해 초음파 조사 조건에 따른 팬텀의 변성을 관찰하였다.

In this study, human head-mimicking phantom was developed for brain disease treatment study using focused ultrasound. Acoustic parameters of skin, skull and brain were investigated through literature investigation and adequate substitutes according to each tissue were suggested. In the case of skin phantom, construction ratio of glycerol-based TMM phantom was controlled to mimic real skin. The suitability of skull substitutes was evaluated through measurement of acoustic parameters. In the case of brain phantom, transparent egg white phantom was used to observe thermal properties of focused ultrasound. Combined human-head-mimicking phantom using each substitutes was fabricated for development of brain disease treatment protocol. Denaturation of brain phantom according to ultrasonic condition was observed for validation.

키워드

참고문헌

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  1. Characteristic Changes Observation of N-isopropylacrylamide Phantom by Repeated Ultrasound Irradiation vol.9, pp.7, 2015, https://doi.org/10.7742/jksr.2015.9.7.509
  2. Feasibility study of pulse compression technique to improve accuracy of ultrasonic temperature estimation vol.6, pp.4, 2016, https://doi.org/10.1007/s13534-016-0237-z
  3. Heating Characteristics Evaluation of Superposed Sonication Using Glycerol Tissue Mimic Phantom vol.9, pp.7, 2015, https://doi.org/10.7742/jksr.2015.9.7.523