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Cultivation Characteristics and Variation of Artemisinin Contents by Harvest Time of Artemisia annua L. Distributed in Korea

한국산 개똥쑥의 재배특성 및 수확시기에 따른 Artemisinin의 함량변이

  • 이정훈 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이상훈 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 박춘근 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 박충범 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김옥태 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 최애진 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김용주 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 차선우 (농촌진흥청 국립원예특작과학원 인삼특작부)
  • Received : 2013.09.09
  • Accepted : 2013.10.29
  • Published : 2013.12.30

Abstract

This study was conducted to obtain the basic data for using the Artemisia anuua as a new economic crop, thus Artemisia anuua was investigated their cultivation characteristics, yield, and variation of artemisinin contents by planting density and harvesting times. Seed characteristics of A. anuua have observed micro-size, and their germination optimum temperature was at 15 to 20 celsius degree. Planting density on the yield of A. anuua was increased high density better than low density. The highest yield was planted in the space of $30{\times}10$cm. Moreover, optimum harvesting time of A. anuua was investigated in early september and a periods of most highly detected artemisinin was time of before and after blooming of A. anuua.

Keywords

References

  1. Abdin MZ, Israr M, Rehman RU and Jain SK. (2003). Artemisinin, anovel antimalarial drug: Biochemical and molecular approaches for enganced production. Planta Medica. 69:289-299. https://doi.org/10.1055/s-2003-38871
  2. Banyai W, Mii M and Supaibulwatana K. (2011). Enhancement of artemisinin content and biomass in Artemisia annua by eogenous GA3 treatment. Plant Growth Regulation. 63:45-54. https://doi.org/10.1007/s10725-010-9510-9
  3. Bhakuni RS, Jain DC, Sharma RP and Kumar S. (2001). Secondary metabolites of Artemisia annua and their biological activity. Current Science. 80:35-48.
  4. Choi HJ, Kim EJ, Han MJ, Baek IN, Kim DH, Jung HG and Kim NJ. (2007). Hepatoprotective effect of fermented Artemisia princeps Pampanini by lactic acid bacteria. Korean Journal of Pharmacognosy. 38:245-253.
  5. Choi SR, Ju IO, You DH, Song YE, Jang I and Ryu J. (2007). Changes of major components and growth characteristics according to harvesting times of Artemisia capillaris Thunberg. Korean Journal of Medicinal Crop Science. 15:189-193.
  6. Ferreira JFS, Simon JE and Janick J. (1995). Developmental studies of Artemisia annua: Flowring and artemisinin production under greenhouseand field conditions. Planta Medica. 61:167-170. https://doi.org/10.1055/s-2006-958040
  7. Firestone GL and Sundar SN. (2009) Anticancer activities of artemisinin and its bioactive derivatives. Expert Reviews in Molecular Medicine. 11:e32. https://doi.org/10.1017/S1462399409001239
  8. Gonzalez FA, Qu G, Zhou LL, Sarevitz CH, Shurtleff JL and Xie DY. (2011). Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants. Planta. 234:685-697. https://doi.org/10.1007/s00425-011-1430-z
  9. Hien TT and White NJ. (1993). Qinghaosu. Lancet. 341:603-608. https://doi.org/10.1016/0140-6736(93)90362-K
  10. Hwang TE. (2009). Changes in antioxidant activity during growth of Artemisia iwayomogi. Korean Journal of Medicinal Crop Science. 17:286-292.
  11. Kim CG, Im DJ, Yu HS and Lee ST. (1994). effect of planting density on the growth and yield of Ligusticum chuanxiong Hort. Korean Journal of Medicinal Crop Science. 2:26-31.
  12. Kim DH, Park CB and Kim JY. (2010). Effect of propagation method, planting density, amount of nitrogen fertilizer and cropping years on growth and yield of Asparagus cochinchinensis(Lour). Merr. Korean Journal of Medicinal Crop Science. 18:93-97.
  13. Kim MS, Chung BJ, Park GC, Park TD, Kim SC and Shim JH. (1998). Effect of planting density on the growth characteristics and root yield of Achyranthes japonica N. Korean Journal of Medicinal Crop Science. 6:137-141.
  14. Klayman DL. (1985). Qinghaosu(artemisinin): Antimalarial drug from China. Science. 228:1049-1055. https://doi.org/10.1126/science.3887571
  15. Kwon BS, Shin JS, Hyan KH and Shin JS. (2002) Effects of row width and plant spacing within row on yield in Scutellaria baicalensis George. Korean Journal of Plant Resources. 15:77-80.
  16. Lee JH, Park CB, Park CG and Moon SG. (2010). A phylogenetic analysis of Korean Artemisia L. based on ITS sequences. Korean Journal of Plant Resources. 23:293-302.
  17. Lee JH, Park CB, Park CG, Son YD and Moon SG. (2010). Studies on major agronomic characteristics of korean Artemisia annua L. Korean Journal of Medicinal Crop Science. 18:46-50.
  18. Lee JH. (2009). A taxonmy study of the genus Artemisia to develop medicinal resources in Korea. Ph. D. Thesis. Kyungsung University. p.1-233.
  19. Lee HA, Hong SH, Han SJ and Kim OJ. (2011). Antimicrobial effects of the extract of Galla rhois on the long-term swine clinical trial. The Korean Society of Veterinary Clinics. 28:1-6.
  20. Lee JY and An BJ. (2010). Whitening and anti-wrinkle effects of Prunus persica Flos. Journal of Applied Biological Chemistry. 53:154-161. https://doi.org/10.3839/jabc.2010.028
  21. Lim JR, Choo BK, Park CB, Kim DH, Choi SJ and Choi YG. (2004). Germination and growth characteristics in defferent sowing date of Artemisia capillaris Thunb. Korean Journal of Medicinal Crop Science. 12:295-299.
  22. Ohgami Y, Elstad CA, Chung E, Shirachi DY, Quock RM and Lai HC. (2010) Effect of hyperbaric oxygen on the anticancer effect of artemisinin on molt-4 human leukemia cells. Anticancer Research. 30:4467-70.
  23. Oh S, Kim BJ, Singh NP, Lai H and Sasaki T. (2009). Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide. Cancer Letters. 274:33-39. https://doi.org/10.1016/j.canlet.2008.08.031
  24. Park JS. (1981). Effect of row-width and plant-spacing within row on yield in safflower, Carthamus tinctorius L. Korean Journal of Crop Science. 26:357-362.
  25. Park YJ and Chung YO. (1996). Studies on the characteristics of seed germination of Lycoris genera. Korean Journal of Medicinal Crop Science. 4:163-171.
  26. Rita B, Benedetta I, Stefano P, Giancarlo M, Franco FV and Anna RB. (2008). Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth. Biochemical Systematics and Ecology. 36:340-348. https://doi.org/10.1016/j.bse.2007.11.002
  27. Ryu JH, Kim RJ, Lee SJ, Kim IS, Lee HJ and Sung NJ. (2011). Nutritional properties and biological activities of Artemisia annua L. Journal of the Korean Society of Food Science and Nutrition. 40:163-170. https://doi.org/10.3746/jkfn.2011.40.2.163
  28. Ryu JH, Lee SJ, Kim MJ, Shin JH, Kang SK, Cho KM and Sung NJ. (2011). antioxidant and anticancer activities of Artemisia annua L. and determination of functional compounds. Journal of the Korean Society of Food Science and Nutrition. 40:509-516. https://doi.org/10.3746/jkfn.2011.40.4.509
  29. Ryu IH and Kwon TO. (2012). The antioxidative effect and ingredients of oil extracted from Schizandra chinensis seed. Korean Journal of Medicinal Crop Science. 20:63-71. https://doi.org/10.7783/KJMCS.2012.20.1.063
  30. Ryu SN. (2008). Bioactive constituents and utilities of ganghwayakssuk (Artemisia princeps Pamp). The Journal of the Korean Society of International Agriculture. 20:308-314.
  31. Van NFCW, Vande CSRF, Maes L, Goossens A, Inze D, Van BJ and Deforce DLD. (2006). Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole timeof-flight tandemmass spectrometry. Journal of Chromatography A. 1118:180-187. https://doi.org/10.1016/j.chroma.2006.03.121
  32. Yand SA, Pyo BS, Kim SM and Lee KI. (2012). Antibacterial activity and nitric oxide production inhibitory activity of the extract and its fractions from the leaves of Prunus sargentii. Korean Journal of Medicinal Crop Science. 20:63-71. https://doi.org/10.7783/KJMCS.2012.20.4.308

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