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Review about effects of sleep disturbances on Burning mouth syndrome

수면장애가 구강작열감 증후군에 미치는 영향에 대한 고찰

  • Lim, Hyun-Dae (Department of Oral medicine, School of Dentistry, Wonkwang University) ;
  • Lee, You-Mee (Department of Oral medicine, School of Dentistry, Wonkwang University)
  • 임현대 (원광대학교 치과대학 구강내과학 교실 및 원광치의학 연구소) ;
  • 이유미 (원광대학교 치과대학 구강내과학 교실 및 원광치의학 연구소)
  • Received : 2013.11.20
  • Accepted : 2013.12.02
  • Published : 2013.12.30

Abstract

The aim of this study was to the relationship between sleep disturbances and Burning mouth syndrome(BMS). BMS presents as a chronic burning sensation in the oral mucous membrane that is frequently associated with sleep disturbances. BMS is considered neuropathic pain condition with dysfunction of small diameter afferent sensory fiber. A review of the studies reveals, BMS suggested peripheral and cental nervous system changes. Sleep disruption or Rem sleep deprivation cause an inhibition of opioid protein synthesis and a reduced affinity of ${\mu}$ and ${\delta}$ opioid receptors. Let me say that sleep disturbances suggest a risk factor For BMS and support to evaluate as a part of BMS treatment. Further study will be required to ascertain the relationship between distruption of sleep continuity or Rem sleep deprivation and BMS and the evidence of altered neurochemical degeneration of BMS.

수면은 외부의 자극에 대해 반응하지 않는 상태로 만성통증을 지닌 환자는 수면 장애를 겪고 있으며 수면장애는 통각과 민한 상태를 유발하고 통증인지에 영향을 미친다. 구강작열감 증후군은 구강점막에 화끈거리는 감각을 포함하는 만성 안면통증으로 감각과 통증 역치가 변성되고 신경병증 징후를 보인다. 구강작열감 증후군은 첫 번째로 국소적, 전신적 요인 즉, 흡연, 투약 등 작열감 증상의 원인으로 가능한 요인을 제거하고, 두 번째로는 환자를 안심시키는데 있다. 수면박탈 내인성, 외인성 아편유사제의 진통효과는 수면 계속성 즉, 선택적인 렘수면 박탈은 아편유사제 진통효과를 방해 하고 opioid protein synthesis 억제를 야기하고 ${\mu}$${\delta}$ opioid 수용체 친화력을 감소시킨다. enkephalinase-inhibitor와 MAO-B inhibitor 적용으로 나타나는 아편유사제의 진통상승효과는 렘수면 박탈시에 무효화 된다. 렘수면 박탈후에는 5-HT 와 5-hydroxy indole acetic acid 레벨이 유의하게 감소되고, 아편유사체에 활성에 의해 유발되는 통증억제를 지지하는 세로토닌 체계를 가능하지 않게 한다. 구강작열감 증후군은 설말단 신경섬유에서 추삭변성 변화가 있고 특히, 열자극, 냉자극 및 미각 유해수용성 자극의 인지를 포함한 감각변화가 폐경기후 생식스테로이드의 급격한 감소가 신경활성 스테로이드 생성에 변성을 일으켜며, 이것은 말초성 변성와 중추성 변성이 존재함을 제시한다. 구강작열감 증후군은 기본적으로 가능한 요인을 제거하는 것이 중요하므로 구강작열감의 진행을 방지하고, 만정적인 작열감의 경감을 위하여 증상 경과에 영향을 미칠 수 있는 수면에 대하여 고찰하고자 한다.

Keywords

References

  1. Carskadon MA, Dement WC. Normal human sleep : an overview. In principle and practice of sleep medicine. 3rd ed., Philadelphia, 2000, W.B. Saunders Co. pp.15-25.
  2. Lavigne GJ, Cistulli PA, Smith MT. Sleep medicine for dentists : a practical overview. 2009, Quintessence Publishing Co. pp 3-4.
  3. Merrill RL. Orofacial Pain and Sleep. Sleep Medicine Clinics 2010;5:131-144. https://doi.org/10.1016/j.jsmc.2009.10.008
  4. Lautenbacher S, Kundermann B, Krieg JC. Sleep deprivation and pain perception. Sleep Med Rev 2006;10:357-369. https://doi.org/10.1016/j.smrv.2005.08.001
  5. Shivpuri A, Sharma S, Trehan M, et al. Burning mouth syndrome: A comprehensive review of literature. Asian Journal of Oral and Maxillofacial Surgery 2011;23:161-166. https://doi.org/10.1016/j.ajoms.2011.06.002
  6. Forssell H, Teerijoki-Oksa T, Kotiranta U, et al. Pain and pain behavior in burning mouth syndrome: a pain diary study. J Orofac Pain 2012;26:117-125.
  7. Headache Classification Subcommitte of the international Headache Society. the international classification of headache disorders: 2nd ed. Cephalgia 2004;24(suppl 1):9-160. https://doi.org/10.1111/j.1468-2982.2003.00824.x
  8. Jaaskelainen SK. Pathophysiology of primary burning mouth syndrome. Clin Neurophysiol 2012;123:71-77. https://doi.org/10.1016/j.clinph.2011.07.054
  9. Schuh-Hofer S, Wodarski R, Pfau DB, et al. One night of total sleep deprivation promotes a state of generalized hyperalgesia: a surrogate pain model to study the relationship of insomnia and pain. Pain 2013;154:1613-1621. https://doi.org/10.1016/j.pain.2013.04.046
  10. Min BK, Jung JK, Choi JK. Clinical features affecting the efficacy of systemic clonazepam for management of burning mouth syndrome. Korean J Oral Med 2012;37(3):161-167.
  11. De Souza FT, Teixeira AL, Amaral TM, et al. Psychiatric disorders in burning mouth syndrome. J Psychosom Res 2012;72:142-146. https://doi.org/10.1016/j.jpsychores.2011.11.008
  12. Crow HC, Gonzalez Y. Burning Mouth Syndrome. Oral and maxillofacial surgery clinics of North America 2013;25:67-76. https://doi.org/10.1016/j.coms.2012.11.001
  13. Mazza S, Magnin M, Bastuji H. Pain and sleep: from reaction to action. Neurophysiol Clin 2012;42:337-344. https://doi.org/10.1016/j.neucli.2012.05.003
  14. Schutz TC, Andersen ML, Tufik S. Sleep alterations in an experimental orofacial pain model in rats. Brain Res 2003;993:164-171. https://doi.org/10.1016/j.brainres.2003.09.006
  15. Lavigne GJ, Goulet JP, Zuconni M, et al. Sleep disorders and the dental patient: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:257-272. https://doi.org/10.1016/S1079-2104(99)70025-9
  16. Bjorvatn B, Gronli J, hamre F, et al. Effects of sleep deprivation on extracelluar serotonin in hippocampus and frontal cortex of rat. Neuroscience 2002;113:323-330. https://doi.org/10.1016/S0306-4522(02)00181-1
  17. Abbot FV, Etienne P, Franklin KB, et al. Acute tryptophan depletion blocks morphine analgia in the cold-pressor test in humans. Psychopharmacology 1992;10860-10866.
  18. Zakrzewska JM, Forssel H, Glenny AM. Interventions for the treatment of burning mouth syndrome. Cochrane database syst Rev 1005;(1):CD002779.
  19. Bergdahl J, Anneroth G, Perris H. Cognitive therapy in the treatment of patient with resist burning mouth syndrome:a controlled study. J Oral Pathol Med 1995;24(5):213-215. https://doi.org/10.1111/j.1600-0714.1995.tb01169.x
  20. Ko JY, Park IH, Park HK, et al. Outcome predictors of initial treatment with topical lubricant and parafunctional habit control in burning mouth syndrome (BMS). Arch Gerontol Geriatr 2011;53:263-269. https://doi.org/10.1016/j.archger.2010.10.020
  21. Chainani-Wu N, Madden E, Silverman S, Jr. A case-control study of burning mouth syndrome and sleep dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112: 203-208. https://doi.org/10.1016/j.tripleo.2011.03.014
  22. Asplund R. Nocturia in the elderly in relation to thirst, dry mouth and dry eyes. Can J Urol 2004;11:1749-1753.
  23. Asplund R. Nocturia and the burning mouth syndrome (BMS) in the elderly. Arch Gerontol Geriatr 2005;41:255-260. https://doi.org/10.1016/j.archger.2005.04.003
  24. Wagner J, Wagner ML Hening WA. Beyond benzodiazepines:alternative pharmacologic agents for the treatment od insomnia. Ann Pharmacother 1998;32:680-691. https://doi.org/10.1345/aph.17111
  25. Passarella S, Duong MT. Diagnosis and Treatment of insomnia. Am J Health Syst Pharm 1008;65:927-934.
  26. Sardella A, Lodi G, Dermarosi F et al. Burning mouth syndrome: a respective study investigating spontaneous remission and response to treatment. Oral Dis 2006;12:152-155. https://doi.org/10.1111/j.1601-0825.2005.01174.x

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