Food Science and Preservation (한국식품저장유통학회지)

The Korean Society of Food Preservation (한국식품저장유통학회)
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Anti-oxidative and skin barrier effects of natural plants with a supercritical extract

초임계 추출을 적용한 식물추출물의 항산화 및 피부장벽 효과

  • Kim, Bora (Research and Development Center of Skin Science and Cosmetics, Enprani Corporation) ;
  • Lee, Su Min (Research and Development Center of Skin Science and Cosmetics, Enprani Corporation) ;
  • Hwang, Tae-Young (Department of Food Science and Industry, Jungwon University) ;
  • Kim, Hyun-Soo (Department of Food Science and Industry, Jungwon University)
  • 김보라 ((주)엔프라니 피부과학연구소) ;
  • 이수민 ((주)엔프라니 피부과학연구소) ;
  • 황태영 (중원대학교 한방식품산업학과) ;
  • 김현수 (중원대학교 한방식품산업학과)
  • Received : 2013.06.28
  • Accepted : 2013.08.19
  • Published : 2013.10.30
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Abstract

In this study, we searched for bioactive compounds from natural resources with a supercritical extract. We selected the extracts of Chrysanthemum zawadskii, Lufa cylindrica, Paeonia lactiflora, Gardenia jasminoides and Scutellaria baicalensis, as natural materials, and evaluated the effects of their skin barrier function. We found that these extracts increased the transactivation activity of the PPAR-responsive element (PPRE) and the anti-oxidation with different priorities, respectively. In addition, these extracts promoted the expression of proteins related to cornified envelope (CE) formation, such as involucrin. From these results, we suggest that natural materials from supercritical extracts will be pertinent candidates for the improvement of the epidermal permeability barrier function.

본 연구에서는 다양한 식물추출물의 항산화성 및 미용관련 기능성을 알아보기 위하여 기존의 용매추출에 비해 안전성이 높은 것으로 알려진 초임계 추출방식을 적용하여 구절초(Chrysanthemum zawadskii), 수세미(Lufa cylindrica), 작약(Paeonia lactiflora), 치자나무(Gardenia jasminoides) 및 황금(Scutellaria baicalensis)의 천연식물 초임계 추출물을 확보하고, 이들의 항산화력 및 피부장벽 향상 효과를 조사하였다. 초임계 식물추출물의 피부장벽기능 향상 효과를 조사하기 위하여 항산화 활성 외 proliferator-activated receptor(PPAR)-${\alpha}$ 활성, cornified envelope(CE)에 관련된 단백질인 involucrin의 발현량을 측정하였다. 이들 추출물 중 황금추출물이 가장 높은 항산화 활성을 보였으며, 모든 추출물에서 대조군과 비교하여 유의적으로 높은 수준의 PPAR-${\alpha}$ 활성을 나타내었다. 또한, 피부장벽 기능 지표 단백질인 involucrin 발현량도 모든 추출물에서 높게 나타났으며, 황금추출물이 가장 높은 단백질 발현 양상을 보였다. 따라서 본 연구에서 조사한 5개 식물의 초임계 추출물은 항산화 및 피부장벽 기능개선과 같은 기능성 생물활성 소재로 활용 될 수 있을 것으로 판단된다.

Keywords

References

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