Health Policy and Management (보건행정학회지)

Korean Academy of Health Policy and Management (한국보건행정학회)
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Economic Analysis of Latent Tuberculosis Infection Screening Strategies in Korea

우리나라 잠복결핵감염 검진전략의 경제성 분석

  • Kim, Sang-Won (Department of Health Informatics and Management, Chungbuk National University College of Medicine) ;
  • Kang, Gil-Won (Department of Health Informatics and Management, Chungbuk National University College of Medicine) ;
  • Shin, Sam-Chul (Department of Health Informatics and Management, Chungbuk National University College of Medicine) ;
  • Song, Seung-Eun (Department of Health Informatics and Management, Chungbuk National University College of Medicine)
  • 김상원 (충북대학교 의과대학 의료정보학 및 관리학교실) ;
  • 강길원 (충북대학교 의과대학 의료정보학 및 관리학교실) ;
  • 신삼철 (충북대학교 의과대학 의료정보학 및 관리학교실) ;
  • 송승은 (충북대학교 의과대학 의료정보학 및 관리학교실)
  • Received : 2013.08.28
  • Accepted : 2013.12.16
  • Published : 2013.12.31
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Abstract

Background: Although interferon-gamma release assay (IGRA) is now available alternatives to tuberculin skin test (TST) for detection of latent tuberculosis infection (LTBI), the cost of IGRA test is much higher than TST. So economic analysis of LTBI screening strategies have been done in many countries, but there are few reports in Korea. This study examined cost analysis of LTBI screening strategies in Korea. Methods: The economic outcomes were evaluated by five strategies. These were 1) TST alone, 2) IGRA alone, 3) combination of TST and IGRA (TST followed by IGRA) and 4) no testing no prevention, 5) no testing all prevention. Last two strategies were added to compare with three main LTBI screening strategies. Decision analysis model were used to perform economic analysis. A cohort study of Korean Institute of Tuberculosis and the data of published literatures were used to estimate the cost analysis. Results: In a base-case scenario which was assumed that TST specificity was 80%, TST alone was the least expensive strategy. In a alternative scenario which was assumed that TST specificity was 97%, the combination of TST and IGRA was the least expensive strategy. Sensitivity analysis shows that patients adherent rate to LTBI treatment, TST sensitivity, IGRA sensitivity and IGRA specificity did not have a significant impact on the outcomes. Conclusion: In Korea, for the diagnosis of LTBI at the time of child and adolescent, TST alone reduces medical costs compared with IGRA alone or combination of TST and IGRA.

Keywords

References

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