Asian-Australasian Journal of Animal Sciences

  • 제26권1호
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  • Pages.36-42
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  • 2013
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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A Study on BMPR-IB Genes of Bayanbulak Sheep

  • Zuo, Beiyao (Animal Embryo Engineering Center of Nanjing Agricultural University) ;
  • Qian, Hongguang (Inner Mongolia Academy of Agriculture and Animal Husbandry) ;
  • Wang, Ziyu (Animal Embryo Engineering Center of Nanjing Agricultural University) ;
  • Wang, Xu (Xinjiang Bazhou Livestock Station) ;
  • Nisa, Noor (Xinjiang Bazhou Livestock Station) ;
  • Bayier, Aierdin (Xinjiang Hejing Animal Husbandry and Veterinary Station) ;
  • Ying, Shijia (Animal Embryo Engineering Center of Nanjing Agricultural University) ;
  • Hu, Xiaolong (Xinjiang Bazhou Livestock Station) ;
  • Gong, Changhai (Xinjiang Bazhou Livestock Station) ;
  • Guo, Zhiqin (Livestock Breeding Biotechnology Key Laboratory of Agriculture Ministry of Xinjiang Academy of Animal) ;
  • Wang, Feng (Animal Embryo Engineering Center of Nanjing Agricultural University)
  • 투고 : 2012.04.19
  • 심사 : 2012.09.05
  • 발행 : 2013.01.01
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초록

The average twin lambing rate of Bayanbulak sheep is 2% to 3%. However, a flock of sheep with a close genetic relationship and an average of 2 to 3 lambs per birth has been found recently. To determine the major genes controlling the prolificacy of the flock in the present study, the flock was designated A while 100 normal Bayanbulak sheep were randomly selected to comprise the control flock B. Ligase detection reaction method was applied to detect and analyze the 10 mutational loci of the 3 candidate prolificacy genes including bone morphogenetic protein type I receptors, bone morphogenetic protein 15, and growth differentiation factor 9. The 10 mutational loci are as follows: FecB locus of the BMPR-IB gene; $FecX^I$, $FecX^B$, $FecX^L$, $FecX^H$, $FecX^G$, and $FecX^R$ of the BMP15 gene; and G1, G8, and FecTT of the GDF9 gene. Two mutations including BMPR-IB/FecB and GDF9/G1 were found in Bayanbulak sheep. Independence test results of the two flocks demonstrate that the FecB locus has a significant effect on the lambing number of Bayanbulak sheep. However, the mutation frequency of the G1 locus in GDF9 is very low. Independence test results demonstrate that the GDF9 locus does not have a significant impact on the lambing performance of Bayanbulak sheep. Among the 10 detected loci, BMPR-IB/FecB is the major gene that influences the high lambing rate of Bayanbulak sheep.

키워드

참고문헌

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피인용 문헌

  1. Progress on major genes for high fecundity in ewes vol.1, pp.4, 2014, https://doi.org/10.15302/J-FASE-2014042
  2. Genotyping of Novel SNPs in BMPR1B, BMP15, and GDF9 Genes for Association with Prolificacy in Seven Indian Goat Breeds vol.27, pp.3, 2016, https://doi.org/10.1080/10495398.2016.1167706
  3. FecX Bar a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine Sheep vol.18, pp.1, 2017, https://doi.org/10.1186/s12863-017-0510-x
  4. Molecular Cloning of the B4GALNT2 Gene and Its Single Nucleotide Polymorphisms Association with Litter Size in Small Tail Han Sheep vol.8, pp.10, 2018, https://doi.org/10.3390/ani8100160
  5. Differential expression of BMP/SMAD signaling and ovarian-associated genes in the granulosa cells of FecB introgressed GMM sheep vol.66, pp.3, 2013, https://doi.org/10.1080/19396368.2019.1695977
  6. The expression and mutation of BMPR1B and its association with litter size in small-tail Han sheep (Ovis aries) vol.64, pp.1, 2013, https://doi.org/10.5194/aab-64-211-2021
  7. Correlation analysis of candidate gene SNP for high-yield in Liaoning cashmere goats with litter size and cashmere performance vol.32, pp.1, 2013, https://doi.org/10.1080/10495398.2019.1652188