Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Heat-processed ginseng saponin ameliorates the adenine-induced renal failure in rats

  • Kim, Eun Jin (College of Pharmacy, Kyung Hee University) ;
  • Oh, Hyun-A (College of Pharmacy, Kyung Hee University) ;
  • Choi, Hyuck Jai (East-West Medical Research Institute, Kyung Hee University Medical Center) ;
  • Park, Jeong Hill (College of Pharmacy, Seoul National University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
  • Kim, Nam Jae (East-West Medical Research Institute, Kyung Hee University Medical Center)
  • Received : 2012.07.17
  • Accepted : 2012.09.25
  • Published : 2013.01.15
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Abstract

To evaluate the effect of the saponin of heat-processed ginseng (Sun ginseng, SG), we investigated the protective effect of SG total saponin fraction against adenine-induced chronic renal failure in rats. SG saponin significantly decreased the levels of urea nitrogen and creatinine in the serum, but increased the urinary excretion of urea nitrogen and creatinine, indicating an improvement of renal function. SG saponin also inhibited adenine-induced kidney hypertrophy and edema. SG saponin reduced serum glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and lactate dehydrogenase activities increased by adenine. Based on these findings, the ameliorating effect of SG on chronic renal failure may result from its saponin.

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