Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Glutathione-S-transferase (GSTM1, GSTT1) Null Phenotypes and Risk of Lung Cancer in a Korean Population

  • Piao, Jin-Mei (Department of Public Health, Qingdao University Medical College) ;
  • Shin, Min-Ho (Department of Preventive Medicine, Chonnam National University) ;
  • Kim, Hee Nam (Center for Creative Biomedical Scientists, Chonnam National University) ;
  • Cui, Lian-Hua (Department of Public Health, Qingdao University Medical College) ;
  • Song, Hye-Rim (Department of Preventive Medicine, Chonnam National University) ;
  • Kweon, Sun-Seog (Department of Preventive Medicine, Chonnam National University) ;
  • Choi, Jin-Su (Department of Preventive Medicine, Chonnam National University) ;
  • Kim, Young-Chul (Lung and Esophageal Cancer Clinic, Chonnam National University Medical School, Hwasun Hospital) ;
  • Oh, In-Jae (Lung and Esophageal Cancer Clinic, Chonnam National University Medical School, Hwasun Hospital) ;
  • Kim, Kyu-Sik (Lung and Esophageal Cancer Clinic, Chonnam National University Medical School, Hwasun Hospital)
  • Published : 2013.12.31
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Abstract

Purpose: The aim of this study was to evaluate any association of GSTM1 and GSTT1 null genotypes with the risk of lung cancer in a South Korean population. Methods: We conducted a large-scale, population-based case-control study including 3,933 lung cancer cases and 1,699 controls. Genotypes of GSTM1 and GSTT1 were determined using real-time polymerase chain reaction. Results: In logistic regression analysis adjusted for age and smoking, we did not find any association between GSTM1 or GSTT1 and LC risk in women. However, in men, the GSTM1 and GSTTI null genotypes were borderline associated with risk (OR=1.18, 95% CI=0.99-1.41 for GSTM1, OR=1.18, 95% CI=0.99-1.41 for GSTT1), and combined GSTM1 and GSTT1 null genotypes conferred an increased risk for LC in men (OR=1.39, 95% CI=1.08-1.78). The OR for the GSTT1 null genotype was greater in subjects aged 55 years old or younger (OR=1.45, 95% CI=1.09-1.92 for men; OR=1.36, 95% CI=0.97-1.90 for women), than in those over age 55 (OR=1.03, 95% CI=0.83-1.27 for men; OR=0.86, 95% CI=0.66-1.12 for women) in both genders (p for interaction <0.05). Conclusions: In the Korean population, the GSTM1 and GSTT1 null genotypes are risk factors for LC in men; the GSTT1 null genotype has a more prominent effect on LC risk in younger people (age 55 years and under) than in older individuals.

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References

  1. Alexandrie AK, Nyberg F, Warholm M, Rannug A (2004). Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population. Cancer Epidemiol Biomarkers Prev, 13, 908-14.
  2. Bartsch H, Nair U, Risch A, et al (2000). Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev, 9, 3-28.
  3. Bell DA, Taylor JA, Paulson DF, et al (1993). Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst, 85, 1159-64. https://doi.org/10.1093/jnci/85.14.1159
  4. Carlsten C, Sagoo GS, Frodsham AJ, Burke W, Higgins JP (2008). Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis. Am J Epidemiol, 167, 759-74. https://doi.org/10.1093/aje/kwm383
  5. Cote ML, Kardia SL, Wenzlaff AS, Land SJ, Schwartz AG (2005). Combinations of glutathione S-transferase genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study. Carcinogenesis, 26, 811-9. https://doi.org/10.1093/carcin/bgi023
  6. Cote ML, Yoo W, Wenzlaff AS, et al (2009) Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis, 30, 626-35. https://doi.org/10.1093/carcin/bgp033
  7. Hayes JD, Pulford DJ (1995). The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol, 30, 445-600. https://doi.org/10.3109/10409239509083491
  8. Ji YN, Wang Q, Lin XQ, Suo LJ (2012). CYP1A1 MspI polymorphisms and lung cancer risk: an updated metaanalysis involving 20,209 subjects. Cytokine, 59, 324-34. https://doi.org/10.1016/j.cyto.2012.04.027
  9. Jung KW, Park S, Kong HJ, et al (2010). Cancer statistics in Korea: incidence, mortality and survival in 2006-2007. J Korean Med Sci, 25, 1113-21. https://doi.org/10.3346/jkms.2010.25.8.1113
  10. Kalemkerian GP, Akerley W, Bogner P, et al (2013). Small cell lung cancer. J Natl Compr Canc Netw, 11, 78-98. https://doi.org/10.6004/jnccn.2013.0011
  11. Kato S, Bowman ED, Harrington AM, Blomeke B, Shields PG (1995). Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. J Natl Cancer Inst, 87, 902-7. https://doi.org/10.1093/jnci/87.12.902
  12. Kim HN, Lee IK, Kim YK, et al (2008). Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma. Br J Haematol, 140, 287-94. https://doi.org/10.1111/j.1365-2141.2007.06893.x
  13. Kohno T, Kunitoh H, Shimada Y, et al (2010) Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis, 31, 834-41. https://doi.org/10.1093/carcin/bgq003
  14. Kohno T, Sakiyama T, Kunitoh H, et al (2006). Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk. Carcinogenesis, 27, 2448-54. https://doi.org/10.1093/carcin/bgl095
  15. Lam TK, Ruczinski I, Helzlsouer K, et al (2009). Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study. Ann Epidemiol, 19, 546-52. https://doi.org/10.1016/j.annepidem.2009.03.003
  16. Landi S (2000) Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res, 463, 247-83. https://doi.org/10.1016/S1383-5742(00)00050-8
  17. Langevin SM, Ioannidis JP, Vineis P, Taioli E (2010). Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines. Pharmacogenet Genomics, 20, 586-97. https://doi.org/10.1097/FPC.0b013e32833c3892
  18. Larsen JE, Colosimo ML, Yang IA, et al (2006). CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung. Carcinogenesis, 27, 525-32. https://doi.org/10.1093/carcin/bgi227
  19. Nakajima T, Elovaara E, Anttila S, et al (1995). Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. Carcinogenesis, 16, 707-11. https://doi.org/10.1093/carcin/16.4.707
  20. Nazar-Stewart V, Vaughan TL, Stapleton P, et al (2003). A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer. Lung Cancer, 40, 247-58. https://doi.org/10.1016/S0169-5002(03)00076-X
  21. Peto R, Darby S, Deo H, et al (2000). Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ, 321, 323-9. https://doi.org/10.1136/bmj.321.7257.323
  22. Piao JM, Shin MH, Kweon SS, et al (2009). Glutathione-Stransferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. World J Gastroenterol, 15, 5716-21. https://doi.org/10.3748/wjg.15.5716
  23. Schneider J, Bernges U, Philipp M, Woitowitz HJ (2004). GSTM1, GSTT1, and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett, 208, 65-74. https://doi.org/10.1016/j.canlet.2004.01.002
  24. Shields PG (1999) Molecular epidemiology of lung cancer. Ann Oncol, 10, S7-11.
  25. Sobin LH, Gospodarowicz M, Wittekind C (2009). TNM Classification of Malignant Tumors. 7th ed. Wiley-Liss, New York.
  26. Sobti RC, Kaur P, Kaur S, et al (2008). Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer. Biomarkers, 13, 282-95. https://doi.org/10.1080/13547500701843437
  27. Sobue T, Yamamoto S, Hara M, et al (2002). Cigarette smoking and subsequent risk of lung cancer by histologic type in middle-aged Japanese men and women: the JPHC study. Int J Cancer, 99, 245-51. https://doi.org/10.1002/ijc.10308
  28. Sorensen M, Autrup H, Tjonneland A, Overvad K, RaaschouNielsen O (2004). Glutathione S-transferase T1 nullgenotype is associated with an increased risk of lung cancer. Int J Cancer, 110, 219-24. https://doi.org/10.1002/ijc.20075
  29. Spitz MR, Duphorne CM, Detry MA, et al (2000). Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomarkers Prev, 9, 1017-20.
  30. Stucker I, Hirvonen A, de Waziers I, et al (2002). Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility. Carcinogenesis, 23, 1475-81. https://doi.org/10.1093/carcin/23.9.1475
  31. Taioli E, Gaspari L, Benhamou S, et al (2003). Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years. Int J Epidemiol, 32, 60-3. https://doi.org/10.1093/ije/dyg001
  32. To-Figueras J, Gene M, Gomez-Catalan J, et al (1997). Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among Northwestern Mediterraneans. Carcinogenesis, 18, 1529-33. https://doi.org/10.1093/carcin/18.8.1529
  33. Wang LI, Giovannucci EL, Hunter D, et al (2004). Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control, 15, 977-85. https://doi.org/10.1007/s10552-004-1093-1
  34. Zhang Y, Hua S, Zhang A, et al (2013). Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers. Clin Lung Cancer, 14, 45-9. https://doi.org/10.1016/j.cllc.2012.04.004

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